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Tim Moran, Ph.D.

Timothy H. Moran, Ph.D.
Paul R. McHugh Professor of Motivated Behaviors
Professor of Psychiatry and Behavioral Sciences

See Research on Pubmed | See Research on Google Scholar

Male

Titles

  • Paul R. McHugh Professor of Motivated Behaviors
  • Vice Chair for Research
  • Director, Behavioral Neuroscience Laboratory
  • Associate Director, Johns Hopkins Global Center for Obesity Prevention
  • Professor of Psychiatry and Behavioral Sciences

Centers & Institutes

  • Behavioral Neuroscience Laboratory

Expertise

Eating and Weight Disorders, Obesity

Research Interests

Obesity; Brain/Gut Interactions in the Controls of Food Intake; Neural and Epigenetic Bases of Psychiatric Disorders

Languages

  • English

Additional Resources

Additional Resources +
  • Education +

    Education

    • B.A., Trinity College, Hartford, Connecticut, 1972, Psychology
    • Ph.D., Johns Hopkins University, Baltimore, Maryland, 1982, Biopsychology

    Fellowships

    • Johns Hopkins University School of Medicine, Baltimore, Maryland, 1982, Neurochemistry
  • Research & Publications +

    Research Summary

    Our overall research program is aimed at identifying the roles of various neural signaling pathways in the controls of food intake and body weight and how these systems go awry in obesity and eating disorders.  Specific projects have focused on: brain/gut peptides as feedback mediators of satiety and how signals arising from these peptides interact with hypothalamic signaling systems mediating overall energy balance, interactions between exercise and food intake, how alterations in cellular energy availability and production result in signals that modify food intake, and how developmental and epigenetic factors can produce long term alterations in neural signaling that bias the organism’s long term metabolic phenotype. We conduct experiments at multiple levels using cell and rodent models as well as nonhuman primates and normal and patient populations. This work has resulted in over 325 original data articles, reviews and book chapters. 

    Selected Publications View all on PubMed

    Tamashiro, K.L.K., Terrillion, C.E., Hyun, J., Koenig, J.I. and Moran, T.H.: Prenatal stress or high fat diet increases susceptibility to diet-induced obesity in rat offspring. Diabetes 58:1116-1125, 2009. 

    Yang, L., Scott, K.A., Hyun, J., Tamashiro, K.L., Tray, N., Moran, T.H. and Bi, S.: Role of dorsomedial hypothalamic NPY in modulating food intake and energy balance. Journal of Neuroscience, 29:179-190, 2009.

    Chakraborty, A., Koldobskiy, M.A., Bello, N.T., Maxwell, M., Potter, J.J., Juluri, K.R., Maag, D., Kim, S., Huang, A.S., Dailey, M.J., Saleh, M., Snowman, A.M., Moran, T.H., Mezey, E. and Snyder, S.H.: Inositol pyrophosphates inhibit Akt signaling, regulate insulin sensitivity and weight gain. Cell, 143:897-910, 2010. 

    Chao, P-T., Yang, L., Aja, S., Moran, T.H. and Bi, S. Knockdown of NPY expression in the dorsomedial hypothalamus promotes brown fat adipogenesis and prevents diet induced obesity. Cell Metabolism 13: 573-583, 2011. 

    Gao, S., Zhu, G., Gao, X., Wu, D., Carrasco, P., Casals, N., Hegardt, F.G., Moran, T.H. and Lopaschuk, G.D.: Important roles of brain specific carnitine palmitoyltrasnferase and ceramide metabolism in leptin hypothalamic control of food intake. Proceedings of the National Academy of Sciences 108: 9691-9696, 2011. 

    Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H-K.,West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenin, T., Arbez, N., Zhu, S., Sommers,K., Qian, J., Zhang, J., Mori, S., Yang, X.W., Tamashiro, K.L.K., Aja, S., Moran, T.H., Luthi-Carter, R., Martin, B., Maudsley, S., Mattson, M.P., Cichewicz, R.H., Ross, C.A., Holtzman, D.H., Krainc, D. and Duan, W.: Neuroprotective role of SIRT1 in mammalian models of Huntington's disease through activation of multiple SIRT1 targets. Nature Medicine 18:153-158, 2011. 

    Dailey, M.J., Moghadam, A.A. and Moran, T.H.: Jejunal linoleic acid infusions require GLP-1 to inhibit food intake: implications for the effectiveness of Roux-en Y gastric bypass. American Journal of Physiology 301: E1184-E1190, 2011. 

    Lee, R.S., Tamashiro, K.L.K., Aryee, M.J., Murakami, P., Seifuddin, F., Herb, B., Huo, Y., Rongione, M., Feinberg, A.P., Moran, T.H. and Potash, J.P.: Adaptation of the CHARM DNA methylation platform for the rat genome reveals novel brain region-specific differences. Epigenetics 6:1378-1390, 2011.

    Sun, B., Purcell, R.H., Yan, J., Moran, T.H. and Tamashiro, K.L.K.: Maternal high-fat diet during gestation or suckling differentially affects offspring leptin sensitivity and obesity. Diabetes 61: 1-9, 2012. 

    Byerly, M.S., Salayta, M.A., Swanson, R.D., Kwon, K., Peterson, J.M., Wei, Z., Aja, S., Moran, T.H., Blackshaw, S. and Wong, G.W.: Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression. European Journal of Neuroscience, 37: 1033-1047, 2013. 

    Liang, N-C, Bello, N.T. and Moran, T.H.: Additive feeding inhibitory and aversive effects of naltrexone and exendin-4 combinations. International Journal of Obesity, 37: 272-278, 2013.

    Sun, B., Liang, N.C., Ewald, E.R., Purcell, R.H., Boersma, G.J., Yan, J., Moran, T.H. and Tamashiro, K.L.:  Early postweaning exercise improves central leptin sensitivity in offspring of rat dams fed high-fat diet during pregnancy and lactation.   American Journal of Physiology, 305: R1076-R1084, 2013. 

    Liang, N-C., Smith, M. and Moran T.H.: Palatable food avoidance and acceptance learning with different stressors in female rats. Neuroscience, 235: 149-158, 2013.

    Dailey, M.J., Moghadam, A.A. and Moran, T.H.: Nutrient specific feeding and endocrine effects of jejunal infusions in obese animals. American Journal of Physiology, 306: R420-R428, 2014.

    Treesukosol, Y., Sun, B., Moghadam, A., Liang, N.C., Tamashiro, K.L. and Moran, T.H.: Maternal high-fat diet during pregnancy and lactation reduces the appetitive behavioral component in female offspring tested in a brief-access taste procedure. American Journal of Physiology, 306:R499-R509, 2014.

     

  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Cellular and Molecular Medicine

  • Activities & Honors +

    Honors

    1984 Adolf Meyer Fellowship

    2002 Paul R. McHugh Professorship in Motivated Behaviors

    2008 Fellow of the Obesity Society

    2013 Hoebel Creativity Award, Society for the Study of Ingestive Behavior

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Department/Division

    • Psychiatry and Behavioral Sciences -

    For Research Inquiries Contact

    The Johns Hopkins University School of Medicine
    618 Ross
    720 Rutland Avenue
    Baltimore, MD 21205

    Phone: 410-955-2344
    Fax: 410-502-3769

    E-mail: tmoran@jhmi.edu

    Administrative Assistant

    Barbara Cross
    Phone: 410-502-4155
    E-mail: bcross2@jhmi.edu

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