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Charlotte A. Gaydos, Dr.P.H., M.P.H.

Photo of Dr. Charlotte A. Gaydos, Dr.P.H., M.P.H.

Director, Johns Hopkins Center for the Development of Point Of Care Tests for Sexually Transmitted Diseases

Professor of Medicine

Research Interests: Mycoplasma genitalium; Neissseria gonorrhoeae; C. psittaci. Trichomonas vaginalis; C. pneumoniae; Chlamydia trachomatis

Contact for Research Inquiries

855 N. Wolfe Street
Rangos Building, Room 532B
Baltimore, MD 21205 map
Phone: 410-614-0932
Fax: 410-614-9775

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Background

Dr. Charlotte A. Gaydos is a Professor in the Division of Infectious Diseases, Department of Medicine of the Johns Hopkins University School of Medicine and has joint appointments in the Emergency Medicine Department and Epidemiology and Population, Family and Reproductive Health at the Johns Hopkins Bloomberg School of Public Health, and is a member of the Johns Hopkins University Center for Global Health. She received her B.S. in medical technology and her M.S. in medical microbiology from West Virginia University. Her MPH and DrPH in Immunology and Infectious Diseases were received from Johns Hopkins University School of Public Health. Dr. Gaydos is the Director of the Johns Hopkins University International STI, Respiratory Diseases, and Biothreat Research Laboratory. She has 45 years laboratory expertise in microbiology, has authored 27 book chapters, over 400 research articles, and over 600 abstracts and oral presentations.

Dr. Gaydos has conducted multiple FDA clinical trials for new diagnostics for STIs and respiratory pathogens. She has extensive laboratory experience in the development and evaluation of molecular amplification testing techniques for respiratory, urogenital, and biothreat specimens, as well as epidemiology expertise. Dr. Gaydos has performed original research developing DNA amplification tests for Chlamydia trachomatis, C. pneumoniae, C. psittaci, Trichomonas vaginalis, N. gonorrhoeae, Mycoplasma genitalium, and the agents of genital ulcer disease. She performed sentinel STI studies in schools and in male and female military recruits. Her Internet recruitment of at-home, self-collected samples for STI screening has been an effective out-reach program, demonstrating an acceptable method for reaching women and men who may not attend clinics.

Her CAP accredited, CLIA certified, State of Maryland licensed laboratory is a Core Diagnostic/Reference Laboratory for international studies of sexually transmitted infections, respiratory diseases, and trachoma. She was a co-investigator for 10 years for the Mid-Atlantic Regional Center of Excellence (MARCE) for emerging infectious diseases. She is the Principal Investigator of this NIH/NIBIB Center U54 grant to develop point-of-care tests for STIs, as well as a co-investigator for a new NIH Center of Excellence in Influenza Research and Surveillance (CEIRS).

Dr. Gaydos is the Director of the North American Branch for the International Union Against Sexually Transmitted Infections (IUSTI). She serves on the editorial board of the Sexually Transmitted Diseases journal and the executive committees of the American Sexually Transmitted Diseases Association (ASTDA) and the International Society for Sexually Transmitted Diseases Research (ISSTDR). She also serves on the National Chlamydia Laboratory Committee, sponsored by the Centers for Disease Control and Prevention (CDC) and on CDC expert panels for laboratory diagnosis of STDs.

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Titles

  • Director, Johns Hopkins Center for the Development of Point Of Care Tests for Sexually Transmitted Diseases
  • Professor of Medicine
  • Joint Appointment in Emergency Medicine

Research & Publications

Lab

The International Sexually Transmitted Diseases (STD), Respiratory, and Biothreat and Emerging Diseases Research Laboratory

The International Sexually Transmitted Diseases (STD), Respiratory, and Biothreat and Emerging Diseases Research Laboratory conducts research, but is also a clinical and diagnostic laboratory. Our laboratory is recognized internationally for expertise as a reference laboratory for STDs, especially Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, HSV, HPV, and syphilis, as well as for respiratory diseases including Streptococcus pneumoniae, Chlamydia pneumoniae, Mycoplasma pneumoniae, and viral respiratory infections. The laboratory has served as the Core Diagnostic Laboratory and as the Reference Laboratory for many national and international grants for collaborative studies of STDs. In collaboration with the University of Maryland and the Emergency Department of Johns Hopkins University, the laboratory has been performing and analyzing diagnostic PCRs of CSF, blood, joint, and peritoneal fluids for biothreat agents as well as for more common agents of bacteremia, meningitis and infections of sterile body fluids. The laboratory is licensed by the State of Maryland and is CLIA approved. The International Laboratory is also the home of The Johns Hopkins Center for Point-of-Care Tests for Sexually Transmitted Diseases. Our Mission is to conduct in-house clinical testing of point-of-care (POC) devices, collaborate with scientists and engineers on exploratory technology development projects, complete clinical needs assessments of STD public health care professionals, and provide training to technology developers on clinical issues related to the development of POC devices for STDs. We also create and test unique methods for the diagnosis of sexually transmitted diseases, including Internet recruitment for home collection of urogenital samples sent by mail for testing by the laboratory, including eventual delivery of over-the-counter tests (OTC) POC tests for STDs to end users via the Internet. We are developing novel approaches for measuring acceptability and accuracy of available POC-type assays, such as for HIV and trichomonas, in primary care settings with comparisons between trained and untrained users.

Selected Publications

View all on Pubmed

Gaydos CA. Barnes MR, Quinn N, Jett-Goheen, Hsieh Y-H. Trichomonas vaginalis infection in men who submit self-collected penile swabs after internet recruitment. Sex Transmit Dis. (epub ahead of print January 26, 2013 as 10.1136/sextrans-2012-050946). PMID: 23354525

Jeng K, Hardick J, Rothman R, Yang S, Won H, Peterson S, Hsieh Y-H, Masek B, Carroll K, Gaydos CA. RT-PCR/ESI-MS for Rapid Detection of Biothreat and Common Respiratory Pathogens. J Clin Microbiol (in press).

Gaydos CA, Van Der Pol B, Jett-Goheen M, Barnes M, Quinn N, Clark C, Daniel GE, Dixon PB, Hook III EW, CT/NG Study Group. Performance of the Cepheid CT/NG Xpert Rapid PCR Test for the Detection of Chlamydia trachomatis and Neisseria gonorrhoeae. J Clin Microbiol 51:1666-1672, 2013. PMCID: PMC3716060

Gaydos CA, Solis M, Hsieh Y-H, Jett-Goheen M, Nour S, Rothman R. Use of Tablet-Based Kiosks in the Emergency Department to Guide Patient HIV Self-Testing with a Point-of-Care Oral Fluid Test. Inter J STD Aids. DOI: 10.1177/0956462413487321

Pearce DM, Styles DN, Hardick JP, Gaydos CA. A new rapid molecular point-of-care assay for Trichomonas vaginalis: preliminary performance data. Sex Transmit Dis (in press) April 20, 2013 as 10.1136/sextrans-2012-051000.

Murillo L, Hardick J, Jeng K, Gaydos CA. Evaluation of the Pan Influenza detection kit utilizing the PLEX-ID and influenza samples from the 2011 respiratory season. J Vir Methods 193:173-176, 2013

Melendez JH, Huppert J, Jett-Goheen, Hesse E, Quinn N, Gaydos CA, Geddes CD. Blinded Evaluation of the Microwave-Accelerated Metal-Enhanced Fluorescence (MAMEF) Ultra-Rapid and Sensitive Chlamydia Trachomatis Test Using Clinical Samples. J Clin Microbiol (in press)

Gaydos CA, Barnes M, Jett-Goheen M, Quinn N, whittel P, Hogan T, Hsieh Y_h. Characteristics and predictors of women who obtain rescreening for sexually transmitted infections using www.iwantthekit.org screening program. Internat J STD & AIDS. online July 15, 2013 DOI: 10.1177/0956462483252

Tang YW, Lowery KS, Valsamakis A, Schaefer VC, Chappell JD, White-Abell J, Quinn CD, Li H, Washington CA, Cromwell J, Giamanco CM, Forman M, Holden J, Rothman RE, Parker ML, Ortenberg EV, Zhang L, Lin YL, Gaydos CA. Clinical Accuracy of a PLEX-ID Flu Device for Simultaneous Detection and Identification of Influenza Viruses A and B. J Clin Microbiol. 51:40-45, 2013. PMCID: PMC3536229

Activities & Honors

Honors

  • Achievement award, American Sexually Transmitted Diseases Association, 2008

Professional Activities

  • Director, International Union of Sexually Transmitted Infections (IUSTI), 2008
    President Elect World IUSTI
  • Executive Board, American Sexually Transmitted Diseases Society, 2007
  • Executive Board, International Society for Sexually Transmitted Diseases Research (ISSTDR), 2007
  • Representative, International Union of Sexually Transmitted Infections (IUSTI) North American, 2006 - 2007

Videos & Media

Lectures and Presentations

  • Can we use the Internet to screen adolescents for Chlamydia? Satisfaction and results of thewww.iwantthekit.org.
    Pediatric Grand Rounds (01/18/2008)
    University of Texas Medical Branch, Dept. Pediatrics
  • E-technology, the Internet, and the Chlamydia Epidemic.
    Medical Grand Rounds (01/26/2008)
    Johns Hopkins University Dept. Med
  • Using Internet e-technology to address the epidemic of chlamydia.
    Grand Rounds, OB/GYN (01/20/2009)
    University of Cincinnati Medical Center
  • Can we use the Internet to screen adolescents for Chlamydia?
    Pediatric Grand Rounds , www.iwantthekit.org , Galveston, TX (01/18/2008)
    University of Texas Medical Branch Department of Pediatrics
  • E-technology, the Internet, and the Chlamydia Epidemic.
    Medical Grand Rounds , Baltimore, MD (09/26/2008)
    Johns Hopkins University Department of Medicine
  • Using Internet e-technology to address the epidemic of chlamydia.
    Grand Rounds, OB/GYN , Cincinnati, OH (03/20/2009)
    University of Cincinnati Medical Center
  • E-Health for STI Control
    Australasian Sex Health Conference , Australia, Canberra (01/28/2011)
  • New Diagnostics
    IUSTI World Congress , New Dehli, India (11/02/2011)
  • What is new in POC tests for STIs? Can we treat more STIs with POC tests?
    IUSTI World Congress , New Dehli, India (11/02/2011)
  • Trichomonas infections: Time to do better for our patients.
    Gen-Probe Satellite Symposium. 22nd ECCMID , London, UK (03/31/2012)
  • Trichomonas: The Undervalued But Most Prevalent STI with Value-Added
    BASHH-ASTDA 4th Joint Meeting , Brighton, England (06/26/2012)
  • EPT: To Be or Not To Be?
    13th IUSTI World Congress , Melbourne, Australia (10/15/2012)
  • New technologies in STI diagnosis and control: Promising future
    STI and AIDS World Congress , Vienna, Austria (07/14/2013)
  • I Want The Kit: A Free Home-Based STI Testing (and Re-testing) Resource for Your Patients
    Maryland 2013 Annual STI Update , Baltimore, MD (06/05/2013)
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