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Lawrence P. Schramm, Ph.D.

Photo of Dr. Lawrence P. Schramm, Ph.D.

Professor of Biomedical Engineering

Research Interests: Derangements in blood pressure regulation after spinal cord injury

Background

Dr. Lawrence Schramm is professor of biomedical engineering and neuroscience at the Johns Hopkins University School of Medicine.

For the past 30 years, his research has focused on derangements in blood pressure regulation after spinal cord injury. His recent research focus has been on the spinal processing of this incoming activity using a variety of optogenetic methods in transgenic mice.

Dr. Schramm received his undergraduate degree in engineering from Haverford College and earned his Ph.D. in physiology from the University of Rochester.

He is a Biomedical Engineering Society (BMES) fellow.

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Titles

  • Professor of Biomedical Engineering
  • Professor of Neuroscience

Research & Publications

Research Summary

For over 30 years, Dr. Schramm has studied the derangements in blood pressure regulation after spinal cord injury. Many of these derangements are caused by failure of the spinal cord to process appropriately the inputs it receives from receptors from muscle, skin and internal organs. Recently, his laboratory focus has been on the spinal processing of this incoming activity using a variety of optogenetic methods in transgenic mice.

Dr. Schramm now works collaboratively with several laboratories in the Department of Neuroscience, combining expertise in spinal cord anatomy and physiology, with their expertise in cellular and molecular biology.

This collaboration adds to the already numerous opportunities for Biomedical Engineering students to conduct highly quantitative, systems neuroengineering research in a rich neuroscience environment.

Lab Website: Lawrence P. Schramm Lab

Selected Publications

View all on Pubmed

Recio AC, Becker D, Morgan M, Saunders NR, Schramm LP, McDonald JW 3rd. "Use of a virtual reality physical ride-on sailing simulator as a rehabilitation tool for recreational sports and community reintegration: a pilot study." Am J Phys Med Rehabil. 2013 Dec;92(12):1104-9. doi: 10.1097/PHM.0000000000000012.

Mountney A, Zahner MR, Sturgill ER, Riley CJ, Aston JW, Oudega M, Schramm LP, Hurtado A, Schnaar RL. "Sialidase, chondroitinase ABC, and combination therapy after spinal cord contusion injury." J Neurotrauma. 2013 Feb 1;30(3):181-90. doi: 10.1089/neu.2012.2353.

Castillo DG, Zahner MR, Schramm LP. "Identification of the spinal pathways involved in the recovery of baroreflex control after spinal lesion in the rat using pseudorabies virus." Am J Physiol Regul Integr Comp Physiol. 2012 Sep 15;303(6):R590-8. doi: 10.1152/ajpregu.00008.2012.

Pan B, Grünewald B, Nguyen T, Farah M, Polydefkis M, McDonald J, Schramm LP, Toyka KV, Höke A, Griffin JW. "The lateral thoracic nerve and the cutaneous maximus muscle--a novel in vivo model system for nerve degeneration and regeneration studies." Exp Neurol. 2012 Jul;236(1):6-18. doi: 10.1016/j.expneurol.2012.02.006.

Zahner MR, Kulikowicz E, Schramm LP. "Recovery of baroreflex control of renal sympathetic nerve activity after spinal lesions in the rat." Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1584-90. doi: 10.1152/ajpregu.00295.2011.

Academic Affiliations & Courses

Graduate Program Affiliation

Biomedical Engineering Program

Neuroscience Graduate Program

Activities & Honors

Professional Activities

  • Biomedical Engineering Society
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