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Shukti Chakravarti, M.S., Ph.D.

Shukti Chakravarti, M.S., Ph.D.
Professor
Professor of Medicine
Female

Titles

  • Professor
  • Principal Investigator, Extracellular Matrix (ECM) Biology Laboratory
  • Professor of Medicine
  • Professor of Ophthalmology
  • Professor of Cell Biology

Expertise

Cornea/Anterior Segment Disease, Fibrosis

Research Interests

Crohn's disease; Ulcerative colitis; Extracellular matrix and tissue homeostasis

Biography

Dr. Shukti Chakravarti, Professor of Medicine (Gastroenterology division), Ophthalmology and Cell Biology studies extracellular matrix mediated regulation of inflammation and tissue homeostasis in the eye and inflammatory bowel diseases.

Dr. Chakravarti holds a bachelor's degree from Lady Brabourne College and a master's and PhD from the University of Pittsburgh. She completed a fellowship at the University of Pittsburgh before joining the Johns Hopkins faculty in 2000. She is the section Editor for Experimental Eye Research and is on the Editorial board of PlosOne.

Languages

  • English

Memberships

Association for Research in Vision and Ophthalmology

American Society of Matrix Biology

Additional Resources +
  • Education +

    Education

    • Ph.D., University of Pittsburgh, Pittsburgh, PA
    • Masters, University of Pittsburgh, Pittsburgh, PA
    • B.S., Lady Brabourne College, Calcutta, India

    Fellowships

    • University of Pittsburgh, Pittsburgh, PA, 1993
  • Research & Publications +

    Research Summary

    The Shukti Chakravarti Laboratory is interested in the regulation of cellular functions and tissue homeostasis by the extracellular matrix (ECM). The laboratory investigates functions of collagen-associated extracellular matrix proteins and proteoglycans, lumican, fibromodulin and biglycan in maintaining connective tissue architecture and cellular functions. Lumican regulates collagen fibril structure such that gene targeted mice deficient in lumican manifest Ehlers Danlos Syndrome-like skin fragility, tendon weaknesses and corneal opacity. These ECM proteins also regulate host innate immune responses by interacting with toll-like receptor (TLR) signals to promote sensing of pathogen-associated molecular patterns, or presenting as danger signals themselves. Our investigation of the ECM centers on two barrier tissues, the cornea of the eye and the intestinal mucosa and submucosa.

    Selected Publications

    1. Chakravarti S, Magnuson T, Lass JH, LaMantia C, Jepsen KJ, Carroll H. Collagen fibril defects affecting skin and cornea in lumican-deficient mice. J Cell Biol. 1277-1286. PubMed PMID: 9606218;PubMed Central PMCID: PMC2137175.

    2. Lawrance IC, Fiocchi C, Chakravarti S. 2001. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes.Hum Mol Genet.10:445 PMID:11181568.

    3. Lawrance IC, Wu F, Leite AZA, Willis J,West GA, Fiocchi C, Chakravarti S. A murine model of chronic inflammation-induced intestinal fibrosis down regulated by antisense NF-?B. Gastroenterology. 2003; 125: 1750-1761. PubMed PMID: 14724828.

    4: Wu F, Vij N, Roberts L, Lopez-Briones S, Joyce S, Chakravarti S. 2007a. A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response. J Biol Chem. 282:26409. PMID:17616530.
    View on Pubmed

    5. Wu, F. and Chakravarti, S. 2007b. Differential Expression of Inflammatory and Fibrogenic Genes and Their Regulation by NF-{kappa}B Inhibition in a Mouse Model of Chronic Colitis. J Immunol.179: 6988.

    6. Lee, S., Bowrin, K., Hamad, A. and Chakravarti, S. 2009a Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to ?2 integrin. J. Biol. Chem. 284:23662-9.PMID: 19531489.
    View on Pubmed

    7. Ghosh A, Lee S, Dziarski R, Chakravarti S. 2009b A novel antimicrobial peptidoglycan recognition protein in the cornea. Invest Ophthalmol Vis Sci. 2009 Apr 22. [Epub ahead of print] PubMed PMID: 19387073.
    View on Pubmed

    8. Lohr, K, Sardana, H, Lee, S, Wu, F, Huso, DL, Hamad, AR, Chakravarti, S.Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis. Inflamm Bowel Diseases, 2011 Apr 11. doi: 10.1002/ibd.21713. [Epub ahead of print]. PMID: 21484968; PubMed Central PMCID: 3135758.
    View on Pubmed

    9. Scott S-G, Jun AS and Chakravarti S. Sphere formation from corneal keratocytes and phenotype specific markers. Experimental Eye Research, 2011 Dec;93(6):898-905. Epub 2011 Oct 21. PMID: 22032988 PMCID: 3225580.
    View on Pubmed

    10. Shao H, Lee S, Gae-Scott S, Nakata C, Chen S, Hamad AR, Chakravarti S. Extracellular matrix lumican promotes bacterial phagocytosis and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity. J Biol Chem. 2012 Aug 3. [Epub ahead of print] PubMed PMID: 22865855 PMCID: 3476255.
    View on Pubmed

    11. Shao H, Scott SG, Nakata C, Hamad AR, Chakravarti S. Extracellular matrix protein lumican promotes clearance and resolution of Pseudomonas aeruginosa keratitis in a mouse model. PLoS One. 2013;8(1):e54765. doi: 10.1371/journal.pone.0054765. Epub 2013 Jan 24. PubMed PMID: 23358433; PubMed Central PMCID: PMC3554612.

    Lab

    The Shukti Chakravarti Laboratory The Shukti Chakravarti Laboratory is interested in the regulation of cellular functions and tissue homeostasis by the extracellular matrix (ECM). The laboratory investigates functions of collagen-associated extracellular matrix proteins and proteoglycans, lumican, fibromodulin and biglycan in maintaining connective tissue architecture and cellular functions. Lumican regulates collagen fibril structure such that gene targeted mice deficient in lumican manifest Ehlers Danlos Syndrome-like skin fragility, tendon weaknesses and corneal opacity. These ECM proteins also regulate host innate immune responses by interacting with toll-like receptor (TLR) signals to promote sensing of pathogen-associated molecular patterns, or presenting as danger signals themselves. Our investigation of the ECM centers on two barrier tissues, the cornea of the eye and the intestinal mucosa and submucosa.
  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Cell and Molecular Medicine

    http://cmm.jhu.edu/index.php?title=Home

    Graduate Program in Pathobiology

    http://pathology.jhu.edu/department/training/pathbio.cfm

     

  • Activities & Honors +

    Professional Activities

    Editorial Board, PlosOne journal. Editor, Experimental Eye Research

    Reviewer - Journal of Cell Biology, Journal of Biological Chemistry, Investigative Ophthalmology and Visual Sciences, Experimental Eye Research, Molecular Vision,  Human Molecular Genetics, Inflammatory Bowel Diseases, Gastroenterology, New England Journal of Medicine, Genome Research, American Journal of Physiology.

  • Videos & Media +
  • Events +

    Grand Rounds Lectures

    Inflammatory bowel diseases and mouse models. http://pathology.jhu.edu/calendar/cal_item.cfm?Date=39657

    2008

  • Contact & Locations +

    Department/Division

    • Medicine - Gastroenterology
    • Ophthalmology
    • Cell Biology

    For Research Inquiries Contact

    Phone: (Lab) 410-502-7628
    Phone: (Office) 410-502-7627
    Fax: 410-614-4834
    Johns Hopkins University School of Medicine 720 Rutland Ave.,
    935 Ross
    Baltimore, MD 21205

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