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Photo of Dr. Lois Arend

Lois Johanna Arend, MD PhD

Program Director, Renal Pathology Fellowship Training Program
Associate Professor of Pathology
Female
Appointment Phone

410-955-2386

Main Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Program Director, Renal Pathology Fellowship Training Program
  • Associate Professor of Pathology

Centers & Institutes

  • Comprehensive Transplant Center

Expertise

Pathology, Transplant Pathology

Research Interests

Renal pathology

Biography

Dr. Lois Arend is an associate professor of pathology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include pathology and transplant pathology. Dr. Arend serves as the program director of the renal pathology fellowship training program.

Dr. Arend earned her Ph.D. and M.D. from Michigan State University. She completed her residency in pathology and performed a fellowship in pathology at the University of Michigan Medical School.

Her research interests include the mechanisms of mammalian kidney development.

Languages

  • English
Additional Resources +
  • Education +

    Training

    • Michigan State University Medical Education and Research Center (Grand Rapids MI) (1992)

    Residencies

    • University of Michigan Medical School / Pathology (Ann Arbor MI) (1996)

    Fellowships

    • University of Michigan Medical School / Pathology (Ann Arbor MI) (1998)

    Certifications

    • American Board of Pathology / Anatomic Pathology (1985)
  • Research & Publications +

    Research Summary

    Dr. Arend's laboratory studies the mechanisms of mammalian kidney development. Specifically, their studies involve various cell and molecular biology techniques to determine the role of the bioactive sphingolipid, sphingosine-1-phosphate (S1P), in organogenesis of the kidney. Their research indicates that S1P may be involved in development of conditions such as cystic kidney disease and Meckel syndrome. They also study the pathologic aspects of other kidney disease by various morphologic techniques, including light, immunofluorescence and electron microscopy.

    Selected Publications

    1. Kirby RJ, Jin Y, Fu J, Cubillos J, Swertfeger D, Arend LJ. "Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney." Am J Physiol Renal Physiol. 2009 Mar;296(3):F634-41. doi: 10.1152/ajprenal.90232.2008. Epub 2008 Dec 10.
    2. Lorenz JN, Arend LJ, Robitz R, Paul RJ, MacLennan AJ. "Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice." Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R440-6. Epub 2006 Sep 21.
    3. Fu J, Jin Y, Arend LJ. "Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein." J Biol Chem. 2003 Dec 26;278(52):52660-72. Epub 2003 Sep 30.
    4. Phillips CL, Arend LJ, Filson AJ, Kojetin DJ, Clendenon JL, Fang S, Dunn KW. "Three-dimensional imaging of embryonic mouse kidney by two-photon microscopy." Am J Pathol. 2001 Jan;158(1):49-55.
    5. Arend LJ, Smart AM, Briggs JP. "Mouse beta(6) integrin sequence, pattern of expression, and role in kidney development." J Am Soc Nephrol. 2000 Dec;11(12):2297-305.
    6. Arend LJ, Smart A, Briggs JP. "Metanephric rat-mouse chimeras to study cell lineage of the nephron." Dev Genet. 1999;24(3-4):230-40.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Professional Activities

    Leadership Program for Women Faculty, 2012 - 2013

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 443-287-0166
    Appointment Phone: 410-955-2386
    Location Map

    Department/Division

    • Pathology

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