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Mario Antonio Bianchet, Ph.D.
Assistant Professor of Neurology
Research Interests: Brain Development
My structural biology research targets macromolecules of biomedical interest, and focuses on understanding the relation between their biological function/dysfunction and three-dimensional structure, with a disease-oriented emphasis in pharmacological therapies. This research utilizes biochemical, molecular biology, and in particular biophysical methods such as X-ray diffraction and small angle scattering, computer modeling and simulation. During my structural enzymologist career, I have substantially contributed to the understanding of the relationship between structure and function of a number of biomedical relevant macromolecules in different fields: bioenergetics (rat liver F1-ATPase); cytoprotection and DNA repair, (NAD[P]H Quinone acceptor oxidoreductases 1 and 2, and uracil DNA glycosylase); glycobiology, carbohydrate recognition (galectin-1, F-lectins); axon-guidance in nerve development (MICAL-1); as well as infectious diseases (Mycobacterium tuberculosis L,D-transpeptidases) resulting in 70 publications and 60 structures deposition in the protein databank.
My present interest includes MICAL-1, an monooxygenase that mediates the cytoskeleton reorganization required by axon guidance processes; L,D-transpeptidases; NAD(P)H: quinone acceptor oxidoreductase, and HIV-1 regulatory and accessory proteins. Currently I am developing a structural biology research program focus on neurodegenerative diseases associated with viral infections, seeking the determination and characterization in atomic detail of pharmacologically exploitable protein-protein interactions involving these diseases pathogenesis and progression.
- Assistant Professor of Neurology
- Assistant Professor of Biophysics and Biophysical Chemistry
- Ph.D., Universidad Nacional de La Plata - Facultad de Ciencias Medicina - La Plata (Argentina) (1988)
Research & Publications
Dr. Bianchet's lab focuses on structural and functional studies of proteins involved in neurodegeneration (associated with viral or oxidative-stress causes), nerve-development/regeneration (axon guidance), late-stage cell-wall biosynthesis in Mycobacterium tuberculosis and glycan-binding proteins.
Selected PublicationsView all on Pubmed
Bianchet MA, Pan YH, Basta LAB, Saavedra H, Lloyd EP, Kumar P, Mattoo R, Townsend CA, Lamichhane G. Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem. BMC Biochem. 2017 May 25;18(1):8. doi: 10.1186/s12858-017-0082-4.
Hategan A , Bianchet M.A., SteinerJ, KarnaukhovaE, Emilios DimitriadisE , NathA. HIV-Tat protein complexes with amyloid β peptide to form multifibrillar structures and causes synergistic neurotoxicity. Nat Struct Mol Biol. (2017) Feb 20. [Epub ahead of print] PMID:28218748
Tyagi R, Li W, Parades D, Bianchet MA, Nath A. Inhibition of human endogenous retrovirus-K by antiretroviral drugs. Retrovirology. (2017) Mar 22;14(1):21. PMID:28330477
Alqassim SS, Urquiza M, Borgnia E, Nagib M, Amzel L. M and Bianchet M.A. Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights. Nature Scientific Reports. (2016)Mar 3;6:22176. doi: 10.1038/srep22176
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