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Theresa A. Shapiro, MD PhD

Division Director, Division of Clinical Pharmacology
Professor of Medicine


  • Division Director, Division of Clinical Pharmacology
  • Wellcome Professor of Medicine
  • Wellcome Professor of Pharmacology and Molecular Sciences
  • Professor of Medicine
  • Professor of Pharmacology and Molecular Sciences

Centers & Institutes

  • Center for Global Health

Research Interests

Molecular and clinical pharmacology of antiparasitic drugs; DNA topoisomerases as antiparasitic drug targets; Structure-activity of synthetic antimalarial trioxanes


Dr. Theresa Shapiro is a Professor of Medicine in the Clinical Pharmacology and Pharmacology and Molecular Science departments. She studies the development and discovery of new drugs for sleeping sickness and malaria.

Dr. Shapiro received a medical degree and PhD from the Johns Hopkins University before joining the faculty. She has served on expert committees for the World Health Organization, the U.S. Food and Drug Administration, the National Institutes of Health and the U.S. Pharmacopeia. 


  • English
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    Selected Publications

    Shapiro TA, Ranasinha CD, Kumar N, and Barditch-Crovo P (1999) Prophylactic activity of atovaquone against Plasmodium falciparum in humans. Am J. Trop. Med. Hyg. 60: 831-836.
    View on Pubmed

    Ye L, Dinkova-Kostova AT, Wade KL, Zhang Y, Shapiro TA, Talalay P (2002) Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin Chim Acta. Feb 316(1-2):43-53. Erratum in Clin Chim Acta 2002 Jul: 321 (1-2) 127-9
    View on Pubmed

    Bodley AL, Chakraborty AK, Xie S, Burri C, Shapiro TA. (2003) An unusual type IB topoisomerase from African trypanosomes. Proc Natl Acad Sci USA. Jun 24; 100 (13) 7539-7544.
    View on Pubmed

    Nenortas E, Kulikowicz T, Burri C, Shapiro TA. (2003) Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions. Antimicrob Agents Chemother Sep; 47 (9): 3015-3017.
    View on Pubmed

    Arav-Boger R, Shapiro TA. (2004) Molecular mechanisms of resistance in antimalarial chemotherapy: the unmet challenge. Annu Rev Pharmacol Toxicol Oct 07 (Epub ahead of print)
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    Posner GH, McRiner AJ, Paik JH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B. (2004) Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimmers in rodents. J Med Chem Feb 26: 47(5): 1299-301.
    View on Pubmed
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    • Medicine - Clinical Pharmacology
    • Pharmacology and Molecular Sciences

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