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Yi Ning, M.D., Ph.D.

Photo of Dr. Yi Ning, M.D., Ph.D.

Director, Cytogenetics Laboratory

Associate Professor of Pathology

Research Interests: Cytogenetic diagnosis; Translational research; Detection and characterization of subtle chromosome abnormalities in hematological malignancies

Background

Dr. Yi Ning is an associate professor of pathology at the Johns Hopkins University School of Medicine, and the director of cytogenetics laboratory in molecular pathology division. She co-directs Oncology Tissue Services at the Johns Hopkins Kimmel Cancer Center.

Her research focuses on the detection and characterization of subtle chromosome abnormalities in hematological malignancies. In addition, she has contributed to the development of human chromosome-specific telomere probes and the application of spectral karyotyping for the improvement of cytogenetic diagnosis.

Dr. Ning received clinical and research training at Baylor College of Medicine and the National Human Genome Research Institute, NIH. She is a clinical cytogeneticist certified by the American Board of Medical Genetics.

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Titles

  • Director, Cytogenetics Laboratory
  • Associate Professor of Pathology

Departments / Divisions

Education

Degrees

  • M.D., Fudan University (China) (1984)
  • Ph.D., Baylor College of Medicine - Houston (Texas) (1991)

Research & Publications

Lab

The Cytogenetics Laboratory provides diagnostic services that include karyotype analysis, fluorescence in situ hybridization (FISH) analysis and SNP microarray analysis.

Selected Publications

View all on Pubmed

HoH, SkaistAM, PallavajjalaA, YonescuR, BatistaD, WheelanSJ, NingY. NUP98-PHF23 fusion is recurrent in acute myeloid leukemia and shares gene expression signature of leukemic stem cells. Leuk Res. 2016 Mar 30 [Epub ahead of print]

Rooper LM, Nikolskaia O, Carter J, Ning Y, Lin MT, Maleki Z. A Single EBUS-TBNA Procedure Can Support a Large Panel of Immunohistochemical Stains, Specific Diagnostic Subtyping, and Multiple Gene Analyses in the Majority of Non-Small Cell Lung Cancer Cases. Hum Pathol. 2016 Jan 18 [Epub ahead of print]

Gerber JM, Zeidner JF, Morse S, Blackford AL, Perkins B, Yanagisawa B, Zhang H, Morsberger L, Karp J, Ning Y, Gocke CD, Rosner GL, Smith BD, Jones RJ. Association of Acute Myeloid Leukemia's Most Immature Phenotype with Risk Groups and Outcomes. Haematologica. 2016 Jan 27 [Epub ahead of print]

Xi Y, Li J, Zhang P, Bai W, Gao N, Bai W, Zhang Y, Wu Y, Ning Y. Upregulation of miRNA-17 and miRNA-19 is associated with unfavorable prognosis in patients with T-cell lymphoblastic lymphoma. Exp Mol Pathol. 2015; 99:297-302.

Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD. NUP98-PHF23 is a chromatin modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD domain histone reader function. Cancer Discov. 2014; 4:564-577.

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