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Photo of Dr. Kathleen Barnes

Kathleen Carole Barnes, PhD

Professor of Medicine


  • Professor
  • Director, The Lowe Family Genomics Core
  • Director, Bayview Genetics Research Facility (BGRF)
  • Professor of Medicine

Centers & Institutes

  • Asthma and Allergy Center

Research Interests

Immunogenetics of the allergic response; Genetic epidemiology of acute and chronic obstructive pulmonary disease


Dr. Kathleen Barnes is an Associate Professor of Medicine in the Allergy and Clinical Immunology division.

Dr. Barnes holds a bachelor's degree from the Medical College of Virginia and a PhD from the University of Florida. She completed postdoctoral fellowships at the Johns Hopkins University and at the Jackson Laboratory before joining the Johns Hopkins faculty in 1995. Dr. Barnes is a member of the Phi Kappa Phi Honorary Society, the American Association for the Advancement of Science, the American Academy of Allergy, Asthma and Immunology, the American Society for Human Genetics, the American Anthropological Association, the Society for Applied Anthropology, the American Thoracic Society, the Pulmonary Vascular Research Institute, the Collegium Internationale Allergologicum, and the European Respiratory Society, and also serves on the editorial board of Current Opinion in Allergy & Clinical Immunology. Her work has been recognized with a Resequencing & Genotyping Service Application Award from the National Heart, Lung, and Blood Institute in 2005, a Travel Award from the Assembly on Allergy Immunology & Inflammation, a Loan Repayment Award for Clinical Research from the National Institutes of Health, a New Investigator Award Grant from the Asthma and Allergy Foundation of America in 1998 and 1999, a Maryland Chapter Research Grant from the Asthma and Allergy Foundation of America in 1996, a Travel Award from the American Academy of Allergy and Immunology 1995, a Glaxo Research Travel Award in 1994, a Boehringer Research Travel Award in 1994, a Travel Award from the American Academy of Allergy and Immunology in 1994, a Travel Award from the University of Florida Graduate Student Council in 1992, a Dow-Elanco Research Travel Award in 1991, an S.C. Johnson Research Travel Award in 1988, a Vining Davis Field Research Award in 1988 and a VA Fellowship in 1982.


  • English
Additional Resources +
  • Education +


    • Ph.D., University of Florida, Gainesville, FL, 1992
    • B.S.N., Virginia Commonwealth University, Richmond, VA, 1984
    • Diploma, Johns Hopkins Hospital School of Nursing, Nursing


    • Jackson Laboratory, Bar Harbor, ME, 1997
    • Johns Hopkins University, School of Medicine, Baltimore, MD, 1995, Division of Clinical Immunology
  • Research & Publications +

    Selected Publications

    Barnes, KC, Neely, JD, Duffy, DL, Freidhoff, LR, Breazeale, DR, Schou, C, Naidu, RP, Levett, PN, Renault, B, Kucherlapati, R, Iozzino, S, Ehrlich, E, Beaty, TH, Marsh, DG  1996.  Linkage of Asthma and Total Serum IgE Concentration to Markers on Chromosome 12q: Evidence from Afro-Caribbean and Caucasian Populations. Genomics 37:41-50.
    View on Pubmed

    CSGA (Collaborative Studies on the Genetics of Asthma). 1997. A genome-wide search for asthma susceptibility loci in ethnically diverse populations.  Nat Genet 15:389-392.
    View on Pubmed

    Barnes, KC , DG Marsh.  1998.  The genetics and complexity of allergy and asthma.  Immunol Today 19(7): 325-332. Barnes, KC, Freidhoff, LR, Chiu, Y-F, Juo, S-H, Duffy, DL, Hizawa, H, Naidu, RP, Nickel, R, Ehrlich, E, Schou, C, Beaty, TH, and Marsh, DG 1999.  Dense mapping of chromosome 12q14.3-q24.1 and linkage to asthma and atopy. J Allergy Clin Immunol.  104(1, Pt. 2): 485-491.
    View on Pubmed

    Nickel, R, Willadsen, SA, Freidhoff, LR, Huang, SK, Raana, NP, Caraballo, L, Ehrlich, E, Ober, C, Beaty, T, and Barnes, KC 1999.  Determination of Duffy-phenotypes in three populations of African descent using PCR and sequence specific oligonucleotides. Human Immunol 60:738-742. View on Pubmed

    Nickel, R, Casolaro, V, Wahn, U, Beyer, K, Barnes, KC, Plunkett, B, Freidhoff, LR, Sengler, C, Plitt, J, Schleimer, RP, Caraballo, L, Naidu, RN, Beaty, T, Huang, S-K  2000.  Atopic dermatitis is associated with a functional mutation in the promoter of the CC chemokine RANTES.  J Immunol Feb 1;164(3):1612-1616.
    View on Pubmed

    Mathias, RA, CA Bickel, TH Beaty, GM Petersen, JB Hetmanski, K-Y Liang, and KC Barnes.  2000.   A Genealogical analysis of the Tangier Island, Virginia, Population.  J Phys Anthro.  112:29-38.
    View on Pubmed

    Lonjou, C, Barnes, K, Chen, H, Cookson, WO, Deichmann, KA, Hall, IP, Holloway, JW, Laitinen, T, Palmer, LJ, Wjst, M, Morton, NE  2000.  A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics.  Proc Natl Acad Sci USA 97(20):10942-7.
    View on Pubmed

    Barnes, K.C., Mathias, RA, Nickel, R, Freidhoff, LR, Stockton, ML, Xue, X, Naidu, RP., Levett, PN, Casolaro, V, Beaty, TH 2001.  Testing for gene-gene interaction controlling total IgE in families from Barbados: Evidence of sensitivity regarding linkage heterogeneity among families. Genomics. 71(2):246-251. View on Pubmed

    Liang, K-Y, F-C Hsu, TH Beaty, KC Barnes. 2001. A multipoint linkage disequilibrium mapping approach based on the case-parent trio design. Am. J. Hum. Genet. 68:937-950. View on Pubmed

    F.C. Hsu, K.Y. Liang, T.H. Beaty, and K.C. Barnes. 2002. Unified sampling approach for multipoint linkage disequilibrium mapping of qualitative and quantitative traits. Genetic Epidemiology.  22(4):298 312. View on Pubmed
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Professional Activities

    Phi Kappa Phi Honorary Society American Association for the Advancement of Science (AAAS) American Academy of Allergy, Asthma and Immunology (AAAAI) American Society for Human Genetics (ASHG) American Anthropological Association (AAA) Society for Applied Anthropology (SfAA) American Thoracic Society (ATS) Pulmonary Vascular Research Institute (PVRI) Collegium Internationale Allergologicum (CIA) European Respiratory Society (ERS)
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    • Medicine - Allergy and Clinical Immunology

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