Dr. Tobian’s research team is focused on two main areas of adverse events associated with transfusion:
- Evaluation of the biological mechanisms of allergic transfusion reactions—the most common complication of blood transfusion—and methods to prevent these reactions
- Evaluation of the epidemiologic risk factors of HIV and other sexually transmitted infections
In collaboration with Uganda’s Rakai Health Sciences Program (RHSP), Dr. Tobian’s team has established a research program to evaluate these factors.
Working closely with the RHSP, the investigators are evaluating the efficacy of male circumcision in preventing sexually transmitted infections in men and their female partners.
In addition, using foreskin mucosal tissue, they are assessing the genital cellular immune milieu associated with sexually transmitted infections to develop novel HIV prevention therapies.
- Tobian AAR and Gray RH. “The medical benefits of male circumcision.” JAMA. 2011; 306: 1479-1480.
- Tobian AAR, Kong X, Wawer MJ, Kigozi G, Gravitt PE, Serwadda D, Eaton K, Nalugoda F, Quinn TC, Gray RH. “Circumcision of HIV-infected men and human papillomavirus transmission to female partners: analyses of data from a randomised trial in Rakai, Uganda.” Lancet Infectious Diseases. 2011; 11: 604-612.
- Tobian AAR, Savage WJ, Tisch DJ, Thoman S, King KE, and Ness PM. “Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reduction.” Transfusion. 2011; 51: 1676-1683.
- Tobian AAR, Serwadda D, Quinn TC, Kigozi G, Gravitt PE, Laeyendecker O, Charvat B, Ssempijja V, Riesdel M, Oliver AE, Nowak RG, Moulton LH, Chen MZ, Reynolds SJ, Wawer MJ, Gray RH. “Male circumcision for the prevention of HSV-2 and HPV infections and syphilis.” N Engl J Med 2009; 360:1298-309.
- Tobian AAR, King KE, Ness PM. “Transfusion premedications: a growing practice not based on evidence.” Transfusion 2007; 47:1089-1096.