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School of Medicine
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Shizhong Han, Ph.D.
Associate Professor of Psychiatry and Behavioral Sciences
Dr. Han earned his PhD in genetics from Fudan University, Shanghai, China, in 2006. He did his postdoc training at Yale, where he started his research on genetics of substance dependence in the laboratory of Dr. Joel Gelernter (2008-2012). Prior to joining Johns Hopkins, he was an Assistant Professor (2012-2017) and then a tenured Associate Professor (2017) in the Department of Psychiatry at the University of Iowa. His research has been focused on investigating the genetic basis of psychiatric disorders, especially for alcoholism and substance dependence. He is also involved in developing statistical genetic approaches and computational tools that will facilitate the effort for identifying disease susceptibility genes. Dr. Han have been Principal Investigator on multiple projects funded by the National Institute of Health or private foundations, and have been a co-investigator on several other grants.
- Associate Professor of Psychiatry and Behavioral Sciences
Departments / Divisions
- Ph.D., Fudan University (China) (2006)
Research & Publications
Selected PublicationsView all on Pubmed
Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DD, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic scores for major depressive disorder and risk of alcohol dependence. JAMA Psychiatry, 2017 Aug 16. doi: 10.1001/jamapsychiatry.2017.2269
Martinez-Rivera A, Hao J, Tropea T, Giordano T, Kosovsky M, Lee A, Huganir, Striessnig J, Addy N, Han S*, Rajadhyaksha A. Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Molecular Psychiatry; 2017;doi: 10.1038/mp.2017.9; *co-corresponding author
Wang M, Huang J, Liu Y, Ma L, Potash J, Han S. COMBAT: A Combined Association Test for Genes using Summary Statistics. Genetics, 2017 Sep 6. pii: genetics.300257.2017. doi: 10.1534/genetics
Han S, Yang BZ, Kranzler HR, Liu X, Zhao H, Farrer LA, Boerwinkle E, Potash JB, Gelernter J. Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. American Journal of Human Genetics. 2013;93(6):1027-1034.
Nath SK, Han S, Kim-Howard X, Kelly JA, Viswanathan P, Gilkeson GS, Chen W, Zhu C, McEver RP, Kimberly RP, Alarcon-Riquelme ME, Vyse TJ, Li QZ, Wakeland EK, Merrill JT, James JA, Kaufman KM, Guthridge JM, Harley JB. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nature Genetics. 2008;40(2):152-154