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Thomas Stephen Metkus, Jr, M.D.
Assistant Professor of Medicine
Dr. Thomas Stephen Metkus is an assistant professor of cardiology at the Johns Hopkins University School of Medicine. His research focuses on using cardiac physiology for risk stratification and therapeutics in non-cardiac critical illness such as sepsis and the acute respiratory distress syndrome (ARDS), and optimizing the management of non-cardiac organ failure in primary cardiac diseases such as heart failure and acute coronary syndromes.
Dr. Metkus received his undergraduate degree from Boston University College of Engineering. He earned a medical degree from the University of Pennsylvania School of Medicine and completed a residency at Brigham and Women’s Hospital. After completing residency, Dr. Metkus was a clinical fellow at both Harvard Medical School and Johns Hopkins Hospital.
Prior to joining the faculty at the Johns Hopkins Medical School he was an instructor of medicine at the Harvard Medical School. His educational focus includes teaching clinical cardiology and critical care, echocardiography, and electrocardiography to students, residents, and fellows at the Johns Hopkins Hospital.
- Assistant Professor of Medicine
- MD, University of Pennsylvania School of Medicine (2007)
- Brigham and Women's Hospital / Internal Medicine (2010)
- Johns Hopkins University School of Medicine / Cardiology (2012)
- Johns Hopkins University School of Medicine / Cardiology (2016)
- American Board of Internal Medicine / Cardiovascular Disease (2015)
- American Board of Internal Medicine / Critical Care Medicine (2016)
- American Board of Internal Medicine / Internal Medicine (2010)
Research & Publications
The goals of my research are to a) use cardiac physiology for risk stratification and therapeutics in non-cardiac critical illness such as sepsis and the acute respiratory distress syndrome (ARDS) and b) optimize the management of non-cardiac organ failure in primary cardiac diseases such as heart failure and acute coronary syndromes.
My current research aims to characterize the prognostic impact of biomarkers of myocardial injury and myocardial stretch in ARDS. We hypothesize that a multiple-biomarker risk profile incorporating myocardial injury and myocardial stretch can be used to risk-stratify ARDS patients for particular advanced therapies- such as early initiation of extra-corporeal membrane support or fluid-sparing resuscitation. Our experimental approach leverages data and biological specimens from previously completed clinical trials of ARDS therapies, available via the NIH-sponsored BioLINCC data repository. I have initiated a research project to understand the optimal means of respiratory support- with both invasive and non-invasive ventilation- in patients with respiratory failure due to primary cardiac diseases such as decompensated heart failure and acute coronary syndromes. Finally, we aim to characterize the impact of pre-operative diastolic dysfunction on post-operative outcomes after cardiac surgery.
Activities & Honors
- Levine Young Clinical Investigator Award Finalist, American Heart Association “Use of Mechanical and Non-Invasive Ventilation in STEMI: 12-year Trends and Prognostic Impact”, 2016 - 2017
- Stanley Blumenthal Award, JHH CV Research Retreat 3rd place winner, Clin. Research poster “Use of mechanical and non-invasive ventilation in STEMI: 12-year trends and prognostic impact.”, 2016 - 2017
- Best Poster, Annual ACC Mid Atlantic Capital Cardiology Symposium “Pulmonary Vascular Compliance Predicts Mortality In The Acute Respiratory Distress Syndrome.”, 2015 - 2016
- Laennec Young Clinician Award Finalist, American Heart Association, 2014 - 2015
- Resident Mentor Award, Brigham and Women’s Hospital, Dept. of Medicine, 2010 - 2011
- Chief Medical Resident, Department of Medicine, Brigham and Women’s Hospital, 2012 - 2013
- Coordinator, Fellows’ Grand Rounds Invited Speaker Series, Johns Hopkins Division of Cardiology, 2013 - 2014