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Orly Rachel Kolodner Klein, M.D.
Instructor of Oncology
Specializes in: Children (1-11 years), Infants (up to 1 year), Adolescents (12-18 years)
Languages: English, Hebrew
Expertise: Bone Marrow Failure, Graft-versus-Host Disease, Haploidentical Bone Marrow Transplant, Pediatric Oncology
Dr. Klein is an Instructor in Pediatric Oncology at the Johns Hopkins Kimmel Cancer Center. She was in a dual-degree program as an undergraduate at Barnard College of Columbia University and the Jewish Theological Seminary. She earned her medical degree and did her pediatrics residency at the Mount Sinai School of Medicine, where she won the Gold Humanism award as a medical student and a teaching award as a resident. She began her pediatric oncology fellowship at Johns Hopkins Hospital in 2012.
She conducted her fellowship research in the lab of Dr. Kenneth R. Cooke, director of the Pediatric Blood and Marrow Transplantation program, in 2013, exploring the mechanisms leading to lung injury after bone marrow transplant. Currently, she is exploring the roles of novel proteins identified by proteomics analyses from the plasma of transplant recipients. She has generated promising preliminary data demonstrating that these proteins are essential in the pathway leading to TNFα-mediated endothelial cell injury in the lungs. These preliminary results may provide insight into new targetable proteins to treat lung injury. For many leukemia and lymphoma patients, as well as for those with some other forms of pediatric cancer, bone marrow transplant remains their only treatment option, but unfortunately at a high cost in terms of significant morbidity and even mortality. Dr. Klein’s research into the mechanisms of lung injury could lead to the development of novel treatments that would broaden the accessibility of bone marrow transplant to many adult and pediatric cancer patients.
- Instructor of Oncology
Centers & Institutes
- MD, Mount Sinai School of Medicine (2009)
- Mount Sinai Medical Center / Pediatrics (2012)
- Johns Hopkins University School of Medicine / Oncology (2016)
- American Board of Pediatrics / Pediatrics (2012)
Research & Publications
Klein OR, Chen AR, Gamper C, Loeb D, Zambidis E, Llosa N, Huo J, Dezern AE, Steppan D, Robey N, Holuba MJ, Cooke KR, Symons HJ, Alternative donor hematopoietic stem cell transplantation with post-transplantation cyclophosphamide for nonmalignant disorders. Biol Blood Marrow Transplant 2016; 22(5): 895-901.
Naik S, Nicholas SK, Martinez CA, Leen AM, Hanley PJ, Gottschalk SM, Rooney CM, Hanson IC, , Krance RA, Shpall EJ, Cruz CR, Amrolia P, Lucchini G, Bunin N, Heimall J, Klein OR, Gennery AR, Slatter MA, Vickers MA, Orange JS, Heslop HE, Bollard CM, Keller MD, Adoptive Immunotherapy for Primary Immunodeficiency Disorders with Virus-Specific T-lymphocytes. J Allergy Clin Immunol 2016; pii: S0091-6749(16)00112-3.