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Masanori Hayashi, M.D.

Photo of Dr. Masanori Hayashi, M.D.

Instructor of Oncology

Specializes in: Children (1-11 years), Infants (up to 1 year), Adolescents (12-18 years)

Languages: English, Japanese

Expertise: Bone Tumors, Ewing's Sarcoma, Osteosarcoma, Rhabdomyosarcoma, Soft Tissue Tumors


Dr. Hayashi is a graduate of Keio University School of Medicine in Tokyo, Japan. He came to Johns Hopkins in 2011 as a Pediatric Hematology-Oncology Fellow, after a pediatric residency at Duke University Medical Center. He successfully completed his fellowship in 2014, has worked in the lab of Dr. David Loeb since 2012, and was recruited to the pediatric oncology faculty in 2016.

His research focuses on pediatric sarcomas. Using a unique new approach, he recently described a novel detection method of plasma tumor DNA for use in identifying radiographically undetectable disease in Ewing sarcoma, and has produced exciting data exposing circulating tumor cells in high-grade sarcomas as well as new insights into Ewing sarcoma metastasis biology. This project led to further study of circulating DNA as a novel personalized biomarker, and circulating tumor cells as a novel therapeutic target for high-grade sarcomas.

Additionally, he has begun to draw national recognition as a young investigator in pediatric sarcoma biology. He was recently awarded the 2015 SARC CDA for his work in circulating tumor DNA. more


  • Instructor of Oncology

Departments / Divisions



  • MD, Keio University School of Medicine (2005)


  • Keio University School of Medicine (2007)
  • National Hospital Organization - Tokyo Medical Center / Pediatrics (2007)
  • Duke University School of Medicine / Pediatrics (2010)


  • Johns Hopkins University School of Medicine / Pediatric Oncology (2016)

Board Certifications

  • American Board of Pediatrics / Pediatrics (2010)

Research & Publications

Selected Publications

Hayashi M, Calatroni A, Herzberg B, Ross AK, Rice HE, Thornburg C. Impact of Hydroxyurea on Perioperative Management and Outcomes in Children With Sickle Cell Anemia. J Pediatr Hematol Oncol. 2011 Oct;33(7):487-90.

Goldstein SD, Hayashi M, Albert CM, Jackson KW, Loeb DM. An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis. Clin Exp Metastasis. 2015 Oct;32(7):703-15. doi: 10.1007/s10585-015-9738-x. Epub 2015 Aug 18.

Kahlert UD, Suwala AK, Koch K, Natsumeda M, Orr BA, Hayashi M, Maciaczyk J, Eberhart CG. Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells. J Neuropathol Exp Neurol. 2015 Sep;74(9):889-900. doi: 10.1097/NEN.0000000000000227.

Goldstein SD, Trucco M, Guzman WB, Hayashi M, Loeb DM. A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model. Oncotarget. 2016 Mar 31. doi: 10.18632/oncotarget.8522. [Epub ahead of print]

Hayashi M, Chu D, Meyer CF, Llosa NJ, McCarty G, Morris CD, Levin AS, Wolinsky JP, Albert CM, Steppan DA, Park BH, Loeb DA. Highly personalized detection of minimal Ewing sarcoma disease burden from plasma tumor DNA. Cancer. 2016 Jun 28. doi: 10.1002/cncr.30144. [Epub ahead of print]

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