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Charles Corbin Bailey, D.V.M.

Photo of Dr. Charles Corbin Bailey, D.V.M.

Assistant Professor of Molecular and Comparative Pathobiology

Background

Charles Bailey is a board-certified veterinary anatomic pathologist. He completed his residency at the New England Primate Research Center and post-doctoral training in the laboratory of Dr. Michael Farzan at NEPRC and later Scripps Research Institute where he studied the interferon-induced transmembrane protein family of viral fusion-inhibitor proteins. He joined the Johns Hopkins School of Medicine Department of Molecular and Comparative Pathobiology in 2016.

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Titles

  • Assistant Professor of Molecular and Comparative Pathobiology

Education

Degrees

  • B.S., Massachusetts Institute of Technology (Massachusetts) (2001)
  • D.V.M., Tufts University Cummings School of Veterinary Medicine - N. Grafton (Massachusetts) (2007)

Research & Publications

Research Summary

Over 15 years ago, mutations in the microglial receptor TREM2 were found to cause a rare, progressive, early-onset, and ultimately fatal neurodegenerative disorder known as Nasu-Hakola disease. In 2013, however, a particular mutation in TREM2, the R47H variant, was identified as a major risk factor for the development of late-onset Alzheimer's disease. In 2015, Dr. Bailey identified apolipoprotein E, another major predictor of Alzheimer's disease risk, as the ligand for the TREM2 receptor. His laboratory now focuses on the biology of TREM2 and attempts to understand how TREM2 mutations ultimately result in Nasu-Hakola and Alzheimer's disease.

Selected Publications

Bailey CC, DeVaux LB, Farzan M. The Triggering Receptor Expressed On Myeloid Cells 2 Binds Apolipoprotein E. J Biol Chem. 2015; 290:26033-42

Bailey CC, Kondur HR, Huang IC, Farzan M. Interferon-Induced Transmembrane Protein 3 is a Type II Transmembrane Protein. J Biol Chem. 2013; 288:32184-93

Bailey CC, Huang IC, Kam CA, Farzan M. Ifitm3 Limits the Severity of Acute Influenza in Mice. PloS Pathog. 2012; 8:e1002909.

Bailey CC, Kramer J, Mejia A, MacKey J, Mansfield K, Miller AD. Systemic Spironucleosis in Two Immunodeficient Rhesus Macaques. Vet Pathol. 2010; 47:488-94.

Bailey CC, Zhong G, Huang IC, Farzan M. IFITM-Family Proteins: The Cell's First Line of Antiviral Defense. Ann Rev Virol. 2014; 1:261-283

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