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Ya-Chi Ho, M.D., M.S., Ph.D.

Photo of Dr. Ya-Chi Ho, M.D., M.S., Ph.D.

Co-Director, HIV Cure Scientific Working Group, Johns Hopkins Center for AIDS Research (CFAR)

Assistant Professor of Medicine

Research Interests: Molecular mechanisms of HIV latency; Strategies to cure HIV infections; Assays to measure the size of the latent reservoir ...read more

Background

Dr. Ya-Chi Ho is an Assistant Professor of Medicine at Johns Hopkins University School of Medicine. She serves as the Co-Director of the HIV Cure Scientific Working Group at the Johns Hopkins Center for AIDS Research (CFAR).

She received her M.D. from National Cheng Kung University School of Medicine in Taiwan and M.S. of Clinical Medicine from National Taiwan University School of Medicine. She completed medical residency and fellowship training in infectious diseases at National Taiwan University Hospital in Taiwan. 

Dr. Ho provided inpatient and outpatient services as an infectious disease attending physician at National Taiwan University Hospital, Yun-Lin Branch for one year. She received her Ph.D. and completed a postdoctoral fellowship in HIV cure research from Johns Hopkins before transitioning to a faculty position.

Her research interests include molecular mechanisms of HIV latency, strategies to cure HIV infections and assays to measure the size of the latent reservoir.

She is a member of the American Society for Microbiology.

...read more

Titles

  • Co-Director, HIV Cure Scientific Working Group, Johns Hopkins Center for AIDS Research (CFAR)
  • Assistant Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • M.D., National Cheng Kung University (Taiwan) (2002)
  • M.S., National Taiwan University (Taiwan) (2007)
  • Ph.D., Johns Hopkins University School of Medicine (Maryland) (2013)

Research & Publications

Selected Publications

Pollack, R.A., Jones, R.B., Pertea, M., Bruner, K.M., Martin, A.R., Thomas, A.S., Capoferri, A.A., Beg, S.A., Huang, S.H., Karandish, S., Hao, H., Halper-Stromberg, E., Yong, P.C., Kovacs, C., Benko, E., Siliciano, R.F., Ho, Y.C. Defective HIV-1 proviruses are expressed and can be recognized by cytotoxic T lymphocytes, which shape the proviral landscape. Cell Host Microbe. 2017 Apr 12;21(4):494-506.e4. PMID: 28407485

Hosmane, N.N., Kwon, K.J., Bruner, K.M., Capoferri, A.A., Beg, S., Rosenbloom, D.I., Keele, B.F., Ho, Y.C., Siliciano, J.D., Siliciano, R.F. Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics. J Exp Med. 2017 Apr 3;214(4):959-972. Epub 2017 Mar 24. PMID: 28341641.

Bruner, K.M., Murray, A.J., Pollack, R.A., Soliman, M.G., Laskey, S.B., Capoferri, A.A., Lai, J., Strain, M.C., Lada, S.M., Hoh, R., Ho, Y.C., Richman, D.D., Deeks, S.G., Siliciano, J.D., Siliciano, R.F. Defective proviruses rapidly accumulate during acute HIV-1 infection. Nat Med. 2016 Sep;22(9):1043-9. Epub 2016 Aug 8. PMID: 27500724.

Ho, Y.C., Liang, S., Hosmane, N.H., Wang, J., Laskey, S.B., Rosenbloom ,D. I. S., Lai, J., Blankson, J.N., Siliciano, J.D., Siliciano, R.F. Replication-competent non-induced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell. 2013;155(3):540-551. PMC3896327.

Yukl, S.A., Busch, M., Chun, T.W., Douek, D., Bentsen, C., Eisele, E., Haase, A., Ho, Y.C., Hütter, G., Lee, T.H., Justement, J.S., Keating, S., Li P., Murray, D., Palmer, S., Pilcher, C., Pillai, S., Price, R.W., Rothenberger, M., Schacker, T., Siliciano, J.D., Siliciano, R.F., Sinclair, E., Strain, M., Wong, J., Richman, D.D., Deeks, S.G. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathogens. 2013;9(5):e1003347. PMC3649997.

Activities & Honors

Honors

  • Phi Tau Phi
  • Michael A. Shanoff Research Award/Young Investigator’s Day Award, Johns Hopkins University School of Medicine
  • Young Investigator Award, The 20th Conference on Retroviruses and Opportunistic Infections (CROI)
  • Howard Hughes Medical Institute International Student Research Fellowship
  • American Association for the Advancement of Science (AAAS)/Science Program for Excellence in Science
  • Clinician Research Scholarship, National Health Research Institute, Taiwan
  • Best Teaching Resident Award, National Taiwan University Hospital, Taiwan
  • Best Resident Award, Department of Internal Medicine, National Taiwan University Hospital, Taiwan
  • Best Intern Award, National Cheng Kung University Hospital, Taiwan
  • Phi Beta Kappa
  • Scholarship for PhD Studentship Abroad, Ministry of Education, Taiwan
  • Dean's award, National Cheng Kung University College of Medicine

Memberships

  • American Society for Microbiology, 2012
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