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Amde Selassie Shifera, M.D., M.S., Ph.D.

Photo of Dr. Amde Selassie Shifera, M.D., M.S., Ph.D.

Assistant Professor of Ophthalmology

Male

Languages: English, Amharic

Expertise: Ocular Immunology, Ocular Inflammation Disease, Ophthalmology , Uveitis

Research Interests: conjunctival sarcoid granulomas; uveitic macular edema; pathogenesis of glaucoma; cellular pathways; epidemiology

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Locations

Johns Hopkins Wilmer Eye Institute
Appointment Phone: 410-955-2966

600 N. Wolfe Street
Baltimore, MD 21287 map
Fax: 410-955-2924

Johns Hopkins Wilmer Eye Institute - White Marsh
Appointment Phone: 443-442-2020

4924 Campbell Boulevard
Suite 100
Nottingham, MD 21236 map
Phone: 443-442-2020

Background

Amde Selassie Shifera, M.D., Ph.D., is an assistant professor of ophthalmology at the Wilmer Eye Institute. In addition to comprehensive ophthalmology, he specializes in ocular immunology, including uveitis, panuveitis, scleritis and ocular inflammatory and infectious diseases. His research focuses on investigating the causes of uveitis and in developing new and better means of treatment for uveitis. 

Dr. Shifera received his M.D. from Addis Ababa University in Ethiopia. After ten years of clinical practice in Ethiopia as a general practitioner, he moved to the United States and completed a master’s degree in clinical chemistry at West Chester University and then a Ph.D in microbiology and immunology at the Albert Einstein College of Medicine. Following postdoctoral research fellowships at both Albert Einstein and the University of California, San Francisco, he completed an internship in surgery at the University of Colorado and then his residency in ophthalmology at the University of Florida. Prior to joining the Wilmer faculty in 2015, Dr. Shifera completed a clinical fellowship in uveitis at the Casey Eye Institute at Oregon Health & Science University.

 

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Titles

  • Assistant Professor of Ophthalmology

Departments / Divisions

Education

Degrees

  • MD, Faculty of Medicine Addis Ababa University (1989)

Residencies

  • Shands Hospital at the University of Florida / Ophthalmology (2014)

Fellowships

  • Oregon Health & Sciences University Hospital / Uveitis & External Disease (2015)

Board Certifications

  • Pending/Scheduled / Ophthalmology

Additional Training

  • Drug Enforcement Agency
  • Educational Commission for Foreign Graduates
  • Maryland Board of Physicians

Research & Publications

Research Summary

Research bacterial and fungal DNA in conjunctival sarcoid granulomas (2015 to present)

Research cell signaling pathways in the homeostasis of intraocular pressure and in the pathogenesis of glaucoma (2009-2010) 

Investigate the effects of vitamin D on cellular signaling pathways and in the pathogenesis of systemic lupus erythematosus (2007-2009)

Examine the effects of mutations in IKKγ (NEMO) protein associated with hypohidrotic ectodermal dysplasia-immune deficiency (2001-2007)

 

 

Clinical Trials

Uveitic Macular Edema Trial (POINT) clinical trial

Selected Publications

Choi CS, Zhang L, Abràmoff MD, Sonka M, Shifera AS, Kay CN. Evaluating efficacy of aflibercept in refractory exudative age-related macular degeneration with OCT segmentation volumetric analysis. Ophthalmic Surg Lasers Imaging Retina 2016; 47:245-251

Alvarado JA, Chau P, Wu J, Juster R, Shifera AS, Geske M. Profiling of cytokines secreted by conventional aqueous outflow pathway endothelial cells activated iIn vitro and ex vivo with laser irradiation. Invest Ophthalmol Vis Sci 2015; 56:7100-7108

Shifera AS, Kay CN. Early-onset X-linked retinitis pigmentosa in a heterozygous female harboring an intronic donor splice site mutation in the retinitis pigmentosa GTPase regulator gene. Ophthalmic Genet 2015; 36:251-256

Shifera AS, Suhler EB. An overview of biological therapy for immune-mediated uveitis. Ophthalmol Int 2014; 9:119-122

Shifera AS, Leoncavallo A, Sherwood M. Probable association of an attack of bilateral acute angle-closure glaucoma with duloxetine. Ann Pharmacother 2014; 48:936-939

Alvarado JA, Iguchi R, Martinez J, Trivedi S, Shifera AS. Similar effects of selective laser trabeculoplasty and prostaglandin analogs on the permeability of cultured Schlemm canal cells. Am J Ophthalmol 2010;150:254-264

Shifera AS, Kopplin L, Lin P, Suhler EB. Drug-induced uveitis. Int Ophthalmol Clin. 2015; 55:47-65

Kopplin LJ, Shifera AS, Suhler EB, Lin P. Biological response modifiers in the treatment of noninfectious uveitis. Int Ophthalmol Clin. 2015; 55:19-36

Alvarado JA, Shifera AS. Progress toward understanding the functioning of the trabecular meshwork based on lessons from studies on laser trabeculoplasty (editorial). Br J Ophthalmol 2010; 94:1417-1418

Activities & Honors

Honors

  • Mallinckrodt Research Fellowship Award, Mallinckrodt Foundation, 2015
  • Full Graduate Assistantship, West Chester University of Pennsylvania, 1999 - 2001
  • Addis Ababa University Medal (valedictorian), Addis Ababa University, 1988 - 1988

Memberships

  • International Society for Eye Research, 2016
  • American Academy for Ophthalmology, 2011
  • Association for Research in Vision and Ophthalmology, 2010

Professional Activities

  • Volunteer Coordinator, Ethiopian-Netherlands AIDS Research Project, Ethiopia, 1995 - 1999
    Played a key role in the planning and launching of a large-scale cohort study conducted by a joint research program established between research institutions of Ethiopia and the Netherlands and aimed at investigating the natural history of HIV infection in an African setting
  • Volunteer, Addis Ababa University, Ethiopa
    Collaborated in the investigation of the community burden of schistosomiasis.
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