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Reza Sedighi Manesh, M.D.

Photo of Dr. Reza Sedighi Manesh, M.D.

Assistant Professor of Medicine


Languages: English, Farsi

Research Interests: Diagnostic expertise; Clinical reasoning; Effective teaching


The Johns Hopkins Hospital

600 N. Wolfe Street
Nelson/Harvey Building, Suite 215
Baltimore, MD 21287 map

Contact for Research Inquiries

The Johns Hopkins Hospital
600 N. Wolfe Street
Nelson 215
Baltimore, MD 21287 map


Dr. Reza Sedighi Manesh is an assistant professor of medicine at the Johns Hopkins University School of Medicine. A clinician-educator, he is passionate about patient care and the teaching of both graduate and undergraduate medical trainees. 

His academic interests include the study and teaching of clinical reasoning and diagnostic expertise.

Dr. Manesh earned his M.D. from the University of Pittsburgh School of Medicine. He completed his residency at the University of California San Francisco School of Medicine. more


  • Assistant Professor of Medicine

Departments / Divisions



  • MD, University of Pittsburgh School of Medicine (2012)


  • University of California San Francisco School of Medicine / Internal Medicine (2015)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (2015)

Additional Training

  • American Board of Internal Medicine/Internal Medicine (2015)

Research & Publications

Selected Publications

Manesh RS, Dixson J, and Kohlwes. Exercise in Clinical Reasoning. Don't Drop the Anchor. J Gen Intern Med. 2015 Jan; 30(1):131-5

Manesh RS, Kohlwes RJ. Palmar Crease Pallor. J Gen Intern Med. 2015 Jul;30(7):1034

Ebinger J, Sedighi Manesh R, Dhaliwal G, Sharpe B, Monash B. A coat with a clue. J Hosp Med. 2015 July;10(7):462-6

Watanuki S, Honda H, Minemura N, Manesh RS, Raoult D, Tokuda Y. Exercise in Clinical Reasoning. Sutton's Law: Keep Going Where the Money is. J Gen Intern Med. 2015 Nov;30(11):1711-5

Martin M, Sedighi Manesh R, Henderson MC, Critchfield JM. Exercise in Clinical Reasoning. Diagnostic Scheming. J Gen Intern Med. J Gen Intern Med. 2015 Dec;30(12):1874-8

Zejnullahu K, Khatami S, Manesh RS. Diffuse Alveolar Hemorrhage: Blood, Sweat and Tears. J Gen Intern Med. 2016;31(7):812-813.

Sedighi Manesh R, Rogers SE, Loring Z, Stewart E, Dhaliwal G, Tierney LM. A Physician with Thigh Pain. Fed Practitioner. 2016 June;33(6):42-4.

Activities & Honors


  • Osler Housestaff Full-Time Faculty Teaching Award, Johns Hopkins, 2016
  • The Jeffrey Weingarten Award, UCSF, 2015
  • The Elizabeth Safar Memorial Award for Providing Compassionate Care, University of Pittsburgh, 2012
  • Mayar A. Green, M.D. Student Award for Academic Achievement and Human Qualities, University of Pittsburgh, 2012
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