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Hristelina Stoycheva Ilieva, M.D., Ph.D.

Photo of Dr. Hristelina Stoycheva Ilieva, M.D., Ph.D.

Assistant Professor of Neurology


Languages: English, Bulgarian

Expertise: Amyotrophic Lateral Sclerosis (ALS), Lou Gehrig's Disease, Motor Neuron Diseases , Neurology, Neuromuscular Disease, Neuromuscular Medicine, Neuropathies more

Research Interests: Motor Neuron Disease, ALS

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Johns Hopkins Outpatient Center
Appointment Phone: 410-955-6435

601 N. Caroline St.
Baltimore, MD 21287 map


Dr. Hristelina Ilieva, a native of Bulgaria, has worked for years in the area of ALS research.  She started in Japan with Dr. Koji Abe at Okayama University, where she completed a PhD degree in Neurosciences and investigated the pathogenesis of disease in the SOD1G93A mouse model of ALS. She next completed a postdoctoral fellowship with Dr. Don Cleveland at UCSD, where she worked on the dynein mouse model (Loa) and contributed by clarifying the role of SOD1 in non-neuronal cell types (endothelial cells) for disease pathogenesis. She finished her residency training with Dr. Stanley Appel and the team at the Department of Neurology, Houston Methodist Hospital. After completing a neuromuscular fellowship at Johns Hopkins University, she joined the Neurology department at Johns Hopkins School of Medicine. more


  • Assistant Professor of Neurology

Departments / Divisions



  • MD, Medical University of Plovdiv (1998)


  • Houston Methodist Hospital / Neurology (2014)


  • Johns Hopkins University School of Medicine / Neurology (2015)

Board Certifications

  • American Board of Psychiatry & Neurology / Neurology-General (2014)

Research & Publications

Selected Publications

View all on Pubmed

Foust KD, Salazar DL, Likhite S, Ferraiuolo L, Ditsworth D, Ilieva H, Meyer K, Schmeltzer L, Braun L, Cleveland DW, Kaspar BK, (2013). Therapeutic AAV9-mediated suppression of SOD1 slows disease progression and extends survival in models of inherited ALS, Mol. Ther, 21, 2148-59.

Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V, Cleveland DW, (2010). Misfolded SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS, Neuron, 67, 575-87.

Ilieva H, Polymenidou M, Cleveland DW, (2009). Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond, J. Cell Biol.187, 761-72.

Zhong* Z, Ilieva* H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez J, Lane S, Liu T, Griffin J, Chow N, Castellino F, Stojanovic K, Cleveland D, Zlokovic B, (2009). Activated protein C therapy slows ALS-like disease by transcriptionally inhibiting SOD1 in motor neurons and microglia, J. Clin. Invest. 119, 3437-3449. (*co-first author)

Ilieva H, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW, (2008). Mutation in cytoplasmic dynein (Loa) triggers proprioceptive neuron loss that extends survival only in the mutant SOD1-mediated model of inherited ALS with the highest rate of excitotoxic motor neuron death, Proc. Natl. Acad. Sci. 105, 12599-12604.

Activities & Honors


  • Clinical Research Training Fellowship in ALS Research, Cosponsored by the American Academy of Neurology, the American Brain Foundation, and the ALS Association, 2015 - 2015
  • ANA travel award for top poster abstract, 2014 American Neurological Association Meeting, 2014 - 2014


  • American Academy of Neurology
  • Society for Neuroscience
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