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Kaushik Mandal, M.B.B.S., M.D.

Photo of Dr. Kaushik Mandal, M.B.B.S., M.D.

Lead Surgeon Robotic Cardiac Surgery & Mini-Maze Program

Assistant Professor of Surgery

Male

Languages: English, Hindi

Expertise: Aneurysms, Aortic Aneurysms, Aortic Surgery, Arrhythmia, Atrial Fibrillation, Atrial Septal Defects, Cardiac Surgery, Cardiovascular Surgery, Congenital Heart Disease - Adult, Coronary Artery Bypass Graft Surgery, Coronary Artery Disease, Coronary Bypass Surgery, Heart Bypass, Heart Disease, Heart Failure, Heart Transplant, Irregular Heartbeat, Maze Procedure, Minimally Invasive Aortic Valve Replacement, Minimally Invasive Cardiac Surgery, Minimally Invasive Interventions, Minimally Invasive Mitral Valve Repair, Minimally Invasive Thoracic Surgery, Mitral Stenosis, Mitral Valve Repair, Radiofrequency Ablation for Atrial Fibrillation, Robotic Surgery, Thoracic Aortic Aneurysms, Valvular Heart Disease, Valvular Heart Surgery ...read more

Research Interests: Minimally invasive cardiac surgery; Health care quality and informatics; Robotics and advanced imaging in cardiac surgery; Mitral valve repair ...read more

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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-2800

600 N. Wolfe Street
Sheikh Zayed Tower Suite 7107
Baltimore, MD 21287 map
Phone: 410-955-9510
Fax: 410-955-3809

Background

Dr. Kaushik Mandal is a cardiac surgeon in the Johns Hopkins Medicine Division of Cardiac Surgery. His clinical expertise includes minimally-invasive cardiac surgery, mitral valve repair, aortic surgery, and the surgical management of heart failure. Dr. Mandal serves as an assistant professor of Surgery at the Johns Hopkins School of Medicine.

After graduating the All India Institute of Medical Sciences (AIIMS) in New Delhi, India, Dr. Mandal completed his general surgery training from AIIMS and the Royal College of Surgeons of Edinburgh in London, UK. He began his academic cardiothoracic surgical training in the UK, completing his doctoral research (MD) from the University of London and clinical cardiothoracic surgical training from Guy's & St. Thomas Hospital, St. Mary's Hospital and St. George's Hospital. At the Johns Hopkins School of Medicine, he completed residencies in minimally invasive cardiac surgery and cardiopulmonary transplantation and joined the faculty of the Johns Hopkins University School of Medicine in 2011.

Dr. Mandal’s clinical interests are adult cardiac surgery, especially minimally invasive cardiac surgery, mitral valve repair, aortic surgery and surgical management of heart failure.

His early investigative work focused on inflammation and autoimmunity in the pathogenesis of atrial fibrillation and atherosclerosis, but more recently has shifted to clinical outcomes research in the field of heart failure surgery and mitral valve surgery.Dr. Mandal has authored over 30 peer reviewed articles and numerous book chapters.

...read more

Titles

  • Lead Surgeon Robotic Cardiac Surgery & Mini-Maze Program
  • Cardiac Surgeon
  • Assistant Professor of Surgery

Departments / Divisions

Education

Degrees

  • MBBS, All India Institute of Medical Sciences (1996)

Residencies

  • All India Institute of Medical Sciences / Surgery (1999)
  • St George's Hospital Medical School / Surgery (2002)
  • Johns Hopkins University School of Medicine / Cardiothoracic Surgery (2011)

Fellowships

  • St George's Hospital Medical School / Cardiothoracic Surgery (2008)

Board Certifications

  • Foreign Boards / Cardiothoracic Surgery (2010)

Additional Training

Fellowship, St George's Hospital Medical School / Cardiothoracic Surgery (London SW17 ORE) (2004)

Research & Publications

Clinical Trials

Principal Investigator in Industry sponsored (ORNIM) study: “Evaluation of Cerebral Oxygen Saturation, measured using a novel Ultrasound tagged light methodology, in predicting postoperative delirium in patients undergoing cardiac surgery.’’

Grant amount $155000 (Jan 2013)

 

Selected Publications

JOURNAL ARTICLES

Kumar A, Seenu V, Mohan N, Kaul A, Bhalla A, Batra R, Mandal K, Aggarwal S, Initial experience with day case laparoscopic cholecystectomy in a tertiary care hospital in India. National Medical Journal of India. 1999; 12(3):103-107

Mandal K, West C, The management of immediate post-traumatic seizures in children following minor head injury- time for a multicentre study? Childs Nervous System. 2001; 17(11): 670-673

Mandal K, Jahangiri M, Mukhin M, Poloneicki J, Camm J, Xu Q, Association of anti-heat shock protein 65 antibodies with development of postoperative atrial fibrillation. Circulation. 2004; 110(17): 2588-2590

Gang Y, Hnatkova K, Mandal K, Ghuran A, Camm J, Malik M, Preoperative electrocardiographic risk assessment of atrial fibrillation after coronary artery bypass grafting. Journal of Cardiovascular Electrophysiology. 2004; 15(12):1379-86

Fletcher N, Mandal K, Jahangiri M, Surgical glue resembling left atrial thrombus. Interactive Journal of Cardiovascular and Thoracic Surgery. 2004; 3: 409-410

Mandal K, Torsney E, Poloneicki J, Camm J, Xu Q, Jahangiri M, The association of high intracellular, but not serum, heat shock protein 70 with postoperative atrial fibrillation. Annals of Thoracic Surgery. 2005; 79(3): 865-871

Xiao Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Keichl S, Xu Q, Association of serum soluble heat shock protein 60 with carotid atherosclerosis- clinical significance determined in a follow-up study. Stroke. 2005; 36(12):2571-6

Foteinos G, Afzal AR, Mandal K, Jahangiri M, Xu Q, Anti-heat shock protein 60 autoantibodies induce atherosclerosis in ApoE-deficient mice via endothelial damage. Circulation. 2005;112(8):1206-1213

Brecker S, Mandal K, Harrison T, Griffin G, Varghese A, Pennell DJ, Lester J, Jahangiri M., Hydatid cyst of the Heart. The Annals of Royal College of Surgeons of England. 2005; 87(2): 1-4

Mandal K, Brecker S, Madden B, Quinton P, Jahangiri M, Drug allergy mimicking as recurrent endocarditis-A cautionary tale. British Journal of intensive Care. 2005; 2:107-108

Mandal K, Afzal AR, Brecker SJD, Poloneicki J, Xu Q, Jahangiri M, The association of soluble heat shock protein 60 with toll like receptor 4 polymorphism and severity of coronary artery disease. Heart. 2006; 92(5): 683-685

Edfeldt K, Agerberth B, Rottenberg M, Gudmundsson G, Wang XB, Mandal K, Xu Q, Yan Z, Involvement of antimicrobial peptide LL-37 in human atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology. 2006;26(7):1551-7

Weerasinghe A, Athanasiou T, Philippidis P, Day J, Mandal K, Warren O, Anderson J, Taylor K, Platelet-monocyte pro-coagulant interactions in on-pump surgery. European Journal of CardiothoracicSurgery. 2006; 29(3): 312-318

Afzal AR, Mandal K, Nyamogewa S, Foteinos G, Poloneicki J, Camm AJ, Jahangiri M, Xu Q, The association of Met439Thr substitution in heat shock protein 70 gene with postoperative atrial fibrillation and serum HSP70 level. Cardiology 2007;110(1):45-52

Torsney E, Mandal K, Halliday A, Jahangiri M, Xu Q, Characterization of Progenitor cells in human atherosclerotic lesions. Atherosclerosis. 2007;191(2):259-64

Tavakkoli HM, Saeed I, Mandal K, Kourliouros A, Valencia O, Jahangiri M, Short term outcome following cardiac surgery- a comparison between consultant and trainees performance. Interactive Journal of Cardiovascular and Thoracic Surgery. 2010; Jun;10(6):889-91.

Didangelos A, Xioke Y, Mandal K, Mark B, Jahangiri M, Mayr M, Proteomic characterization of extracellular space components in the human aorta. Mol Cell Proteomics mcp. 2010; Sep; 9(9):2048-62.

Didangelos A, Xioke Y, Mandal K, Jahangiri M, Mayr M, BAS/BSCR9 Proteomic characterization of extracellular space components in the human aorta. Heart. 2010; Sep:96(17): e15

Didangelos A, Yin X, Mandal K, Saje A, Smith A, Xu Q, Jahangiri M, Mayr M, Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. Mol Cell Proteomics. 2011 Aug;10(8): M111.008128

Stegemann C, Didangelos A, Javier BB, Langley S, Mandal K, Jahangiri M, Mayr M Proteomic identification of matrix metalloproteinase substrates in human vasculature Circulation Cardiovascular genetic 2013 1:6(1): 106-17

George TJ, Kilic A, Beaty CA, Conte JV, Mandal K, Shah A Septaugenerians bridged to heart transplantation with a ventricular assist device have similar outcomes as younger patients. Ann Thorac Surg. 2013:95(4):1251-60

Kilic A, Shah AS, Conte JV, Mandal K, Baumgartner WA, Cameron DE, Whitman GJ. Understanding Variability in Hospital-Specific Costs of CABG Represents an Opportunity for Standardizing Care and Improving Resource Utilization. Journal of Thorac & Cardiovasc Surg. 2014:147(1); 109-15

Arora V, Schwartz G, Tilson MP, Netto GJ, Mandal K Right atrial mass- more than meets the eye. Journal of Clin Oncol. 2014:2013.49.3130

Kilic A, Grimm JC, Whitman GJ, Shah AS, Mandal K, Conte JV, Sciortino CM. The Survival Benefit of Simultaneous Heart-Kidney Transplantation Extends Beyond Dialysis-Dependent Patients. Annals of Thoracic Surgery (accepted, in press).


REVIEWS

Mandal K, Strategy in screening mammography The Surgeons perspective. Hospital Today. 1998; 12:742-744

Mandal K, Jahangiri M, Xu Q, Autoimmunity to heat shock proteins in atherosclerosis. Autoimmunity Reviews. 2004; 3(2): 31-37

Mandal K, Foteinos G, Jahangiri M, Xu Q, Role of anti-heat shock protein 60 antibodies in Atherosclerosis. Lupus. 2005;14(9):742-6

Jahangiri M, Weir G, Mandal K, Savelieva I, Camm J, Current strategies in the management of atrial fibrillation. Annals of Thoracic Surgery. 2006;82(1):357-364

Warren O, Mandal K, Hadjianastassiou V, Knowlton L, Panesar S, John K, Darzi A, Athanasiou T, Recombinant activated factor VII in cardiac surgery: a systemic review. Annals of Thoracic Surgery. 2007;83(2):707-14

Xu Q, Bernhard Metzler, Jahangiri M, Mandal K, Molecular chaperones and Heat shock proteins in atherosclerosis. American Journal of Physiology- Heart & Circulatory Physiology. 2012 Feb 1;302(3):H506-14.

Killic A, Mandal K Autoimmunity to Heat Shock Proteins: Pathogenic Role in Atherosclerosis and Potential Therapeutic Implications. Autoimmune Dis. 2012;2012:502813

Mandal K, Alwair H, Nifong WL, Chitwood WR Jr Robotically assisted minimally invasive mitral valve surgery. Journal of Thoracic Disease. 2013;5(S6):S694-S703.



LETTERS / CORRESPONDENCES

Mayr M, Mandal K, Xu Q, Pitfalls of Proteomics. Circulation. 2004; 110(12): e316

Mandal K, Jahangiri M, Mukhin M, Poloneicki J, Camm J, Xu Q, Response to Dr. Auer- Association of anti-heat shock protein 65 antibodies with development of postoperative atrial fibrillation. Circulation. 2005;111(20):e306


BOOK CHAPTERS

Mandal K, Jahangiri M, Xu Q, Autoimmune mechanisms of atherosclerosis. Handbook of experimental pharmacology: arteriosclerosis; influence of diet and drugs. Edited by von Eckardstein A (Springer-Verlag). 2005; 170: 723-743

Mandal K, Chest Trauma. Oxford handbook of cardiothoracic surgery. Edited by Chikwe J (Oxford Speciality Handbooks). 2006; 748-755

Mandal K, Jahangiri M, Xu Q, Endothelial progenitor cells & vascular repair. Cardiac regeneration and stem cell therapy. Edited by Anversa P (Blackwell Scientific). 2007; 57-65

Mandal K Pulmunory infections. Johns Hopkins Manual of Cardiothoracic Surgery. 2nd Edition. Edited by Yuh D, Vricella L, Yang S, Doty J (McGraw Hill Publishers). 2014; 63-88

Mandal K, Cameron D Aortic Root Replacement. Johns Hopkins Manual of Cardiothoracic Surgery. 2nd Edition. Edited by Yuh D, Vricella L, Yang S, Doty J (McGraw Hill Publishers). 2014; 525-538

Mandal K, Weerasena N Cardiac surgery in adults with congenital heart disease. Johns Hopkins Manual of Cardiothoracic Surgery. 2nd Edition. Edited by Yuh D, Vricella L, Yang S, Doty J (McGraw Hill Publishers). 2014; 1377-1398

Sodha NR, Mandal K, Cameron DE Valve Sparing Aortic Root Replacement. Recent Advances in Cardiac Surgery. Edited by Moorjani N, Ohri S, Wechsler A (Hodder Arnold Publishers). 2014; 97-110.

Mandal K, Chitwood WR Jr Robotic Mitral Valve Surgery. Operative Cardiac Surgery. Edited by Spray T & Acker M (CRC Publishers, Taylor Francis Group- In Press)



THESIS FOR MASTER OF SURGERY (All India Institute of Medical Sciences 1999)

Role of mammography in detection of non-palpable breast lesions in Indian women above 40 years with a high-risk profile A hospital based prospective study


DOCTORAL THESEIS (University of London 2005)

Soluble heat shock protein 60 and autoantibodies against heat shock protein 65 and oxidized LDL in patients with chronic stable angina

Activities & Honors

Honors

  • Professor V Ramalingaswami Best Intern Award, All India Institute of Medical Sciences, 1995
  • Awarded Honorary Fellowship in Recognition of academic achievements, European Society of Cardiology, 2007
  • Deans Scholarship, Johns Hopkins Bloomberg School of Public Health , 2011
  • National Scholar, National Council of Educational Research and Training, 1988
  • Member, Royal College of Surgeons of Edinburgh, 2001
  • Fellow, Royal College of Surgeons of Edinburgh, 2007

Memberships

  • European Society of Cardiology
    Fellow
  • European Working Group on Pathogenesis of Atherosclerosis
    Member
  • Halsted Surgical Residents Society of the Johns Hopkins Hospital
  • Royal College of Surgeons of Edinburgh
    Fellow

Professional Activities

  • Administrative Specialist Registrar in Cardiothoracic Surgery, St Georges Hospital, 2007 - 2008
  • Lead Surgeon Robotic Cardiac Surgery & Mini, Johns Hopkins Hospital, 2014
    Maze Program
  • Chief Resident in Thoracic Surgery, Johns Hopkins Hospital, 2009 - 2009
  • Chief Resident in Cardiac Surgery, Johns Hopkins Hospital, 2010 - 2011

Videos & Media

Healing the Heart at Johns Hopkins Medicine

Robotic Mitral Valve Repair Jim Watkins story

Lectures and Presentations

  • Autoimmunity to HSP in Atherosclerosis
     International Congress on Heart, Rheumatism and Autoimmunity , Pescara (01/01/2005)
  • Association of sHSP60 with TLR4 polymorphism and coronary artery disease
    International Congress on Coronary Artery Disease , Venice (01/01/2007)
  • Biomarker for Aortic Dissection- Current Status and Strategies
    Valve Technology and Charring Cross Vascular Surgery Meeting , London (01/01/2012)
  • Minimally Invasive Cardiac Surgery- Who? When? How?
     The Nicholas Fortuin Cardiovascular Topics at Johns Hopkins , Baltimore (01/01/2013)
  • Minimally Invasive Mitral Valve surgery- Future directions
     Cardiology Grand Rounds at Johns Hopkins University School of Medicine , Baltimore (01/01/2013)
  • Minimally Invasive Mitral Valve Repair
     Cardiothoracic Surgery Section , London (01/01/2014)
    Royal Society of Medicine
  • Autoimmunity to Heat Shock Proteins in Atherosclerosis
    Session Chair , Rheumatism and Autoimmunity , Pescara (01/01/2005)
    International Congress on Heart
  • How should we manage immediate posttraumatic seizures in children following minor head injury?
     Society of British Neurosurgeons , Newcastle (01/01/2001)
  • Redo-homograft aortic valve replacement in an 18 week pregnant patient
     Royal Society of Medicine (cardiothoracic section) , London (01/01/2004)
  • Autoantibodies against heat shock protein 65 and oxidised low density lipoprotein – Evidence for autoimmunity in coronary artery disease
     Society of Cardiothoracic Surgeons of Great Britain & Ireland , Guernsey (01/01/2004)
  • The association of mutation in heat shock protein 70 gene with postoperative atrial fibrillation
     American Heart Association , New Orleans (01/01/2004)
  • Characterization of Progenitor cells in atherosclerotic lesions and the adventitia in humans
     American Heart Association , New Orleans (01/01/2004)
  • Autoantibodies to HSP60 enhance atherosclerosis in ApoE-deficient mice via endothelial damage
     British Cardiac Society Annual Conference , Glasgow (01/01/2006)
  • The association of sHSP60 with TLR4 polymorphism and severity of coronary artery disease
     International Society on Coronary Artery Disease , Venice (01/01/2007)
  • Does off-pump Re-do coronary surgery decrease morbidity and mortality– A propensity case matched analysis
    Society of Cardiothoracic Surgeons of Great Britain & Ireland , Edinburgh (01/01/2008)
  • Minimally invasive aortic valve replacements
    Society of Cardiothoracic Surgeons of Great Britain & Ireland , Edinburgh (01/01/2008)
  • Does off-pump Re-do coronary surgery decrease morbidity and mortality– A propensity case matched analysis
    International Society for Minimally Invasive Cardiothoracic Surgery , Boston (01/01/2008)
  • Experience with extra-anatomical bypass for treatment of arch and descending thoracic aneurysms
     Society of Cardiothoracic Surgeons of Great Britain & Ireland , Edinburgh (01/01/2008)
  • Proteomics analysis of extracellular matrix degradation in human abdominal aortic aneurysms
     American Heart Association , Chicago (01/01/2010)
  • Understanding variability in Hospital specific costs of CABG represents an opportunity for standardization of case and improving resource utilization
     American Association of Thoracic Surgery , Minneapolis (01/01/2013)
  • Septaugenerians bridged to heart transplantation with a ventricular assist device have similar outcomes as younger patients
     Hawley Seiler Award recipient at the Southern Thoracic Society of America meeting , Naples (01/01/2012)
  • Robotic mitral valve repair: A single institutional series of 853 procedures
     International Society of Minimally Invasive Cardiothoracic Surgery , Boston (01/01/2014)
  • Robot assisted transitional atrioventricular canal defect repair & maze procedure via left atrial approach
     Society of Thoracic Surgeons , San Diego (01/01/2015)
  • Association of heat shock protein 65 antibodies with development of postoperative atrial fibrillation
     European Society of cardiology , Munich (01/01/2004)
  • Autoantibodies against heat shock protein 65 and oxidised low density lipoprotein – Evidence for autoimmunity in coronary artery disease
     European Society of cardiology , Munich (01/01/2005)
  • Autoantibodies to HSP60 accelerate atherosclerosis in ApoE-deficient mice via endothelial damage
     American Heart Association , New Orleans (01/01/2005)
  • Does P-wave signal averaged electrocardiogram play a role in risk assessment for atrial fibrillation? 
    Europace (01/01/2004)
  • Localisation of stem/ Progenitor cells in atherosclerotic lesions
     British Atherosclerosis Society , Oxford (01/01/2005)
  • Association of hsp70-2 and hsp70-hom polymorphisms with severity of coronary artery disease in patients with chronic stable angina
     European Society of cardiology , Munich (01/01/2004)
  • Autoantibodies to HSP60 accelerate atherosclerosis in ApoE-deficient mice via endothelial damage
     European Society of cardiology , Munich (01/01/2004)
  • Association of serum soluble heat shock protein 60 with carotid atherosclerosis-clinical significance determined in a follow-up study
     European Society of cardiology , Stockholm (01/01/2005)
  • CCR5-del32 genotype modifies pro-inflammatory/anti-inflammator cytokine ratio; possible role in atherogenesis
    Academy of Medical Sciences- Royal College of Physicians , London (01/01/2007)
     Medical Research Society
  • The association of mutation in heat shock protein 70 gene with postoperative atrial fibrillation
    Academy of Medical Sciences- Royal College of Physicians , London (01/01/2007)
     Medical Research Society
  • Association of hsp70-2 and hsp70-hom polymorphisms with severity of coronary artery disease in patients with chronic stable angina
    Academy of Medical Sciences- Royal College of Physicians , London (01/01/2007)
     MedicalResearch Society

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