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William B. Guggino, Ph.D.

Photo of Dr. William B. Guggino, Ph.D.

Director, Department of Physiology

Professor of Physiology


Research Interests: Protein trafficking and localization; Epithelial cell biology; Polycystic kidney disease; Gene therapy; Ion channels; Cystic fibrosis more


Dr. William B. Guggino is a professor of physiology and pediatrics at Johns Hopkins University School of Medicine. He is the director of the Department of Physiology.

An acclaimed cystic fibrosis (CF) researcher, Dr. Guggino also serves as director of the NIH Health Heart, Lung, and Blood Institute’s Cystic Fibrosis Gene Therapy Center (housed at Johns Hopkins) and the Cystic Fibrosis Research Development Program.

Dr. Guggino has dedicated most of his professional life to Johns Hopkins, and his commitment to science is equaled only by his passion for teaching. He has trained and mentored scores of young clinician-scientists in unraveling CF''s mysteries and bringing promising new therapies to patients.

He also has served since 1982 as director of curriculum for first-year medical students, as well as course director in organ-systems physiology and histology.

Among his many accomplishments, Dr. Guggino co-authored with Peter Agre, M.D., a seminal paper published in Science in 1992 detailing the discovery of the first water channel protein. That line of research won Dr. Agre the 2003 Nobel Prize in Chemistry.

Dr. Guggino’s work has been recognized with honors that include the prestigious Doris F. Tulcin Cystic Fibrosis Research Award – which marked his achievements in both research and education – and the Johns Hopkins Excellence in Teaching Award.

Dr. Guggino earned his Ph.D. in zoology from the University of North Carolina at Chapel Hill and his M.S. in comparative physiology from Long Island University. He also holds a B.S. in biology from Brooklyn College. more


  • Director, Department of Physiology
  • Director, Cystic Fibrosis Research Development Program
  • Director, NIH Health Heart, Lung, and Blood Institute, Cystic Fibrosis Gene Therapy Center, Johns Hopkins University
  • Director of Curriculum, First-Year Medical Students
  • Vice Chair, Research, Department of Pediatrics
  • Professor of Physiology
  • Professor of Pediatrics

Departments / Divisions


Additional Training

Yale University School of Medicine, New Haven, CT, 1982, Renal Physiology

Research & Publications

Research Summary

Dr. Guggino’s research interests include cystic fibrosis (CF), ion channels, gene therapy, polycystic kidney disease, epithelial cell biology, and protein trafficking and localization.

His lab currently is investigating the structure and function of chloride and water channels; trafficking and molecular organization of transport proteins in epithelial cell membranes; and genetic therapies for the correction of defective ion transport in CF cells and patients.

Researchers also are working to identify CF’s specific defect in chloride channel regulation. CF is the most common autosomal recessive disease in North America.

Selected Publications

  1. Cebotaru V, Cebotaru L, Kim H, Chiaravalli M, Boletta A, Qian F, Guggino WB. "Polycystin-1 negatively regulates polycystin-2 expression via the aggresome/autophagosome pathway." J Biol Chem. 2014 Jan 23. [Epub ahead of print]
  2. Suk JS, Kim AJ, Trehan K, Schneider CS, Cebotaru L, Woodward OM, Boylan NJ, Boyle MP, Lai SK, Guggino WB, Hanes J. "Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier." J Control Release. 2014 Mar 28;178:8-17. doi: 10.1016/j.jconrel.2014.01.007. Epub 2014 Jan 14.
  3. Cebotaru L, Rapino D, Cebotaru V, Guggino WB. "Correcting the cystic fibrosis disease mutant, A455E CFTR." PLoS One. 2014 Jan 8;9(1):e85183. doi: 10.1371/journal.pone.0085183. eCollection 2014.
  4. Lee HW, Cheng J, Kovbasnjuk O, Donowitz M, Guggino WB. "Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR." PLoS One. 2013;8(3):e59992. doi: 10.1371/journal.pone.0059992. Epub 2013 Mar 28.
  5. Woodward OM, Tukaye DN, Cui J, Greenwell P, Constantoulakis LM, Parker BS, Rao A, Köttgen M, Maloney PC, Guggino WB. "Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules." Proc Natl Acad Sci U S A. 2013 Mar 6;110(13):5223-8. doi: 10.1073/pnas.1214530110. Epub 2013 Mar 14.

Academic Affiliations & Courses

Graduate Program Affiliation

Cellular and Molecular Medicine

Activities & Honors


  • Excellence in Teaching Award, Johns Hopkins
  • Doris F. Tulcin Cystic Fibrosis Research Award, 2005
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