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Sheng Wu, M.Sc., Ph.D.

Photo of Dr. Sheng Wu, M.Sc., Ph.D.

Assistant Professor of Pediatrics

Expertise: Endocrinology , Pediatric Endocrinology

Background

Dr. Sheng Wu is an assistant professor of pediatrics and physiology at the Johns Hopkins University School of Medicine. She has a background in molecular endocrinology, with specific training and expertise in reproductive and metabolic function.

Her postdoctoral training focused on the regulation of insulin signaling in reproductive (pituitary, ovary and hypothalamus) and energy storage tissues (liver, muscle and adipose). Dr. Wu’s laboratory studies the insulin/androgen receptor (AR) actions on the developmental and regulation of the reproductive and metabolic functions. Multiple animal models (obesity, androgen implantation and conditional knockout) are used to investigate the pathophysiology of polycystic ovarian syndrome (PCOS) and the developmental factors and their target tissues that contribute to PCOS manifestation. 

Dr. Wu earned her M.Sc. in aquaculture and zoology from Wageningen University in The Netherlands and her Ph.D. from the University of Victoria in Canada. She completed a postdoctoral fellowship in endocrinology and metabolism at Johns Hopkins. 

Dr. Wu is a member of the Endocrine Society, the American Physiology Society and Women in Endocrinology. She has received numerous awards and honors of distinction for her research, including the American Physiology Society’s Virendra B. Mahesh Award of Excellence in Endocrinology for 2011, the 2014 Endocrinology Society’s Early Investigator Award, Endocrinology Society and the 2011 Women in Endocrinology’s Young Investigator Award.

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Titles

  • Assistant Professor of Pediatrics
  • Joint Appointment in Physiology

Education

Degrees

  • B.A., Ocean University of China (China) (1991)
  • M.Sc., Wageningen Agricultural University (The Netherlands) (2000)
  • Ph.D., University of Victoria (Canada) (2007)

Additional Training

Fellowship
Johns Hopkins University
2011
Endocrinology and Metabolism
Baltimore, MD

Research & Publications

Research Summary

Dr. Wu’s current research examines effect of the insulin/androgen receptor actions on the development and regulation of reproductive and metabolic functions. Multiple animal models (obesity, androgen implantation and conditional knockout) are used to investigate the pathophysiology of polycystic ovarian syndrome (PCOS) and the developmental factors and their target tissues that contribute to PCOS manifestation.

Lab Website: Sheng Wu Laboratory

Selected Publications

View all on Pubmed

DiVall SA, Herrera D, Sklar B, Wu S, Wondisford F, Radovick S, Wolfe A. "Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice." PLoS One. 2015 Mar 17;10(3):e0119995. doi: 10.1371/journal.pone.0119995. eCollection 2015. PubMed PMID: 25780937; PubMed Central PMCID: PMC4363364.

Wu S, Chen Y, Fajobi T, DiVall SA, Chang C, Yeh S, Wolfe A. "Conditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice." Mol Endocrinol. 2014 Oct;28(10):1670-81. doi: 10.1210/me.2014-1154. Epub 2014 Aug 26. PubMed PMID: 25157703; PubMed Central PMCID: PMC4179628.

Wolfe A, Divall S, Wu S. "The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)." Front Neuroendocrinol. 2014 Oct;35(4):558-72. doi: 10.1016/j.yfrne.2014.05.007. Epub 2014 Jun 12. PubMed PMID: 24929098; PubMed Central PMCID: PMC4175134.

Wu S, Divall S, Nwaopara A, Radovick S, Wondisford F, Ko C, Wolfe A. "Obesity-induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell." Diabetes. 2014 Apr;63(4):1270-82. doi: 10.2337/db13-1514. Epub 2013 Dec 30. PubMed PMID: 24379345; PubMed Central PMCID: PMC3964497.

Wolfe A, Wu S. "Estrogen receptor-β in the gonadotropin-releasing hormone neuron." Semin Reprod Med. 2012 Jan;30(1):23-31. doi: 10.1055/s-0031-1299594. Epub 2012 Jan 23. Review. PubMed PMID: 22271291.

Activities & Honors

Honors

  • Early Investigator Award, Endocrinology Society, 2014
  • Endocrinology and Metabolism Section New Investigator Award, American Physiology Society, 2013
  • Eugenia Rosemberg Abstract Award, Endocrine Society, 2012
  • Invited Grant Reviewer, Swiss National Science Foundation, 2011
  • Young Investigator Award, Woman in Endocrinology, 2011
  • Virendra B. Mahesh Award of Excellence in Endocrinology, American Physiology Society, 2011
  • Research grant, Endocrine Fellow Foundation, 2009 - 2010
  • Travel Award, Endocrine Society, 2009
  • Trainee Award, Endocrine Society, 2008

Memberships

  • American Physiology Society, 2011
  • Woman in Endocrinology, 2011
  • The Endocrine Society, 2005

Professional Activities

  • Consultant reviewer, Journal of Molecular Endocrionology
  • Consultant reviewer, Endocrine
  • Consultant reviewer, Journal of Clinical Endocrinology & Metabolism
  • Consultant reviewer, PLOS One
  • Consultant reviewer, Regulated Peptide
  • Consultant reviewer, Diabetes
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