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Andrew Wolfe, Ph.D.

Photo of Dr. Andrew Wolfe, Ph.D.

Director, Research Training in Endocrinology, Division of Pediatric Endocrinology

Associate Professor of Pediatrics

Expertise: Endocrinology , Pediatric Endocrinology, Reproductive Endocrinology

Research Interests: Gene expression regulation; Hypothalamic-pituitary-gonadal axis; Gonadotropin-releasing hormone (GnRH); Reproduction; Obesity; Type 2 diabetes; Reproductive Endocrine; Neurological Endocrine ...read more

Background

Dr. Andrew Wolfe is an associate professor of pediatrics and an assistant professor of physiology at the Johns Hopkins University School of Medicine. 

An endocrinologist, Dr. Wolfe serves as the director of research training in endocrinology in the Division of Pediatric Endocrinology at Johns Hopkins Children's Center. He also is the director of training in basic science for the Endocrine Diabetes and Metabolism Training Program.  

Dr. Wolfe earned his doctoral degree in neuroscience from Northwestern University and completed a research fellowship at Boston Children’s Hospital. Prior to joining the Johns Hopkins faculty in 2007, Dr. Wolfe served as both an assistant professor of pediatrics and Director of Basic Science Research in the University of Chicago’s Division of Pediatric Endocrinology.

His research aims to better understand the regulatory mechanisms of the hypothalamic-pituitary-gonadal axis. Among the body’s most important signaling pathways, this axis controls growth, metabolism and reproduction.

Dr. Wolfe’s work particularly focuses on understanding how the metabolic dysfunction of conditions such as type 2 diabetes, obesity and polycystic ovary syndrome affects reproduction and fertility—as well as the precise signaling pathways that result in those malfunctions.

Some of Dr. Wolfe’s work has yielded valuable new clues about the relationship between insulin sensitivity in the pituitary gland and ovaries and the development of infertility—findings poised to pave the way for new therapies.

Among his honors, Dr. Wolfe was elected in 2013 to the prestigious Society for Pediatric Research for his contributions to the study of childhood disease.

...read more

Titles

  • Director, Research Training in Endocrinology, Division of Pediatric Endocrinology
  • Director, Training in Basic Science, Division of Pediatric Endocrinology
  • Associate Professor of Pediatrics
  • Assistant Professor of Physiology

Education

Degrees

  • B.A., Northwestern University (Illinois) (1988)
  • Ph.D., Northwestern University (Illinois) (1994)

Additional Training

Fellowships
Research
Boston Children’s Hospital/Harvard Medical School
1997
Boston, MA

Research & Publications

Research Summary

Dr. Wolfe’s research centers on understanding the development and functional regulation of the hypothalamic-pituitary-gonadal axis, which controls reproduction. 

Because of a long-standing interest in the regulation of GnRH gene expression and in addition to performing standard in vitro analysis, his laboratory developed a variety of transgenic and knock-out mouse models that have revealed both cis- and trans-regulatory elements underlying the cell-specific expression of GnRH. 

His laboratory is also interested in understanding how metabolic status impacts reproductive function. It has long been known that states of negative energy balance are associated with infertility. These can include anorexia nervosa and can play an important component in functional hypothalamic amenorrhea. What has become clear in recent years is that states of positive energy balance, such as obesity and type 2 diabetes, are also associated with reproductive dysfunction. 

His laboratory has developed a mouse model of obesity-induced infertility. Used in conjunction with mouse models of tissue-specific gene deletion, they are able to probe the role of various molecular signals mediating the effects of obesity on reproductive function. 

Lab Website: Andrew Wolfe Laboratory

Selected Publications

View all on Pubmed

Simavli S, Thompson IR, Maguire CA, Gill JC, Carroll RS, Wolfe A, Kaiser UB, Navarro VM. "Substance P regulates puberty onset and fertility in the female mouse." Endocrinology. 2015 Apr 9:en20142012. [Epub ahead of print]

DiVall SA, Herrera D, Sklar B, Wu S, Wondisford F, Radovick S, Wolfe A. "Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice." PLoS One. 2015 Mar 17;10(3):e0119995. doi: 10.1371/journal.pone.0119995. eCollection 2015.

Salehi S, Adeshina I, Chen H, Zirkin BR, Hussain MA, Wondisford F, Wolfe A, Radovick S. "Developmental and endocrine regulation of kisspeptin expression in mouse leydig cells." Endocrinology. 2015 Apr;156(4):1514-22. doi: 10.1210/en.2014-1606. Epub 2015 Jan 30.

Dubois SL, Acosta-Martínez M, DeJoseph MR, Wolfe A, Radovick S, Boehm U, Urban JH, Levine JE. "Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor α in kisspeptin neurons." Endocrinology. 2015 Mar;156(3):1111-20. doi: 10.1210/en.2014-1851. Epub 2014 Dec 29.

Sanghvi VR, Mavrakis KJ, Van der Meulen J, Boice M, Wolfe AL, Carty M, Mohan P, Rondou P, Socci ND, Benoit Y, Taghon T, Van Vlierberghe P, Leslie CS, Speleman F, Wendel HG. "Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia." Sci Signal. 2014 Nov 18;7(352):ra111. doi: 10.1126/scisignal.2005500.

Petersen PS, Lei X, Seldin MM, Rodriguez S, Byerly MS, Wolfe A, Whitlock S, Wong GW. "Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels." Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1458-70. doi: 10.1152/ajpregu.00335.2014. Epub 2014 Oct 15.

Activities & Honors

Honors

  • Pilot and Feasibility Award, University of Chicago Diabetes Research and Training Center, 2001 - 2003
  • Travel Award, Endocrine Society, 1996 - 1996
  • Travel Award, Endocrine Society, 2000 - 2000
  • National Research Service Award, National Institutes of Health, 1997 - 2000
  • Post-Doctoral Fellowship, Lalor Foundation, 1995 - 1997
  • Young Investigator Award, Workshop on Steroid Hormones and Brain Function Meeting, 1996
  • Teaching Assistant Fellowship, Northwestern University, 1990 - 1991
  • Graduate Student Fellowship, Northwestern University, 1989 - 1990

Memberships

  • Society for Pediatric Research, 2013
  • American Physiological Society, 2011
  • American Neuroendocrine Society, 1996
  • The Endocrine Society, 1994
  • Society for Neuroscience, 1989
  • American Association for the Advancement of Science, 1994 - 1999
  • American Society for Cell Biology, 1995 - 1997

Professional Activities

  • Editorial board, Journal of Clinical Endocrinology and Metabolism, 2012
  • Editorial board, PlOS One, 2012
  • Editorial board, Frontiers in Pituitary Biology, 2010
  • Editorial board, Endocrine, 2009 - 2010
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