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Jian Wang, Ph.D.

Photo of Dr. Jian Wang, Ph.D.

Associate Professor of Anesthesiology and Critical Care Medicine

Research Interests: Neurodegenerative disorders; CAM medicine/Chinese herbal medicine; Hemopexin/haptoglobin; Heme oxygenase/iron/carbon monoxide/bilirubin; Proteases/matrix metalloproteinases/tPA; Neuroinflammation/prostaglandin and its receptors; Oxidative stress injury, neuronal cell death, cell signaling; Aging/Alzheimers disease/amyloid angiopathy; Stroke/hemorrhage/ischemia ...read more

Background

Dr. Jian Wang is an associate professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. His research focuses on understanding the pathophysiology of intracerebral hemorrhage. He is also interested in translational research to identify potential therapeutic targets to treat or limit hemorrhagic brain injury.

Dr. Wang received his medical degree from the Medical College of Henan University in China. He completed a residency in internal medicine and neurology at Kaifeng No. 1 People’s Hospital and another residency in neurology at The Second Affiliated Hospital of Henan University. He then completed a Master of Science in neurology at Henan Medical University and a Ph.D. in neurology at Sun Yat-sen University of Medical Sciences. Dr. Wang was a clinical research fellow in Parkinson’s disease at Sun Yat-sen University of Medical Sciences. He also performed a fellowship in pharmacological sciences at Stony Brook University School of Medicine and a fellowship in anesthesiology and critical care medicine at Johns Hopkins University School of Medicine.

He joined the Johns Hopkins faculty in 2006. Prior to joining Johns Hopkins, he was an instructor in molecular biology with the Institute of Genetics at Fudan University in Shanghai, China.

Dr. Wang is a member of the American Society for Neuroscience, the American Heart Association, the American Stroke Association, the International Society for Cerebral Blood Flow & Metabolism, and the International Stroke Society. He is on the editorial boards of the Chinese Journal of Practical Nervous Diseases and Neural Regeneration Research. Dr. Wang’s work has been recognized by the American Heart Association with a Scientist Development Award and by the Ministry of Education in China with a National Science and Technology Advancement Award.

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Titles

  • Associate Professor of Anesthesiology and Critical Care Medicine

Education

Degrees

  • Ph.D., Sun Yat-sen University (China) (1999)

Research & Publications

Research Summary

Dr. Wang’s research focuses on understanding the pathophysiology of intracerebral hemorrhage (ICH). He uses established preclinical models of hemorrhagic stroke, including the collagenase-induced model and the autologous whole-blood model to search for endogenous proteins as well as potential drugs to prevent or alleviate neuropathic injury.

Dr. Wang is also interested in translational research to identify potential therapeutic targets to treat or limit hemorrhagic brain injury, including complementary and alternative medicines.

He has extensive experience in the study of matrix metalloproteinases (MMPs) and heme oxygenases. He previously demonstrated that MMP-9 is activated and upregulated after ICH and that its inhibition may be neuroprotective and lead to improved outcomes. More recently, he developed an interest in studying the role of prostaglandin E2 (PGE2) receptors after ICH in the aging brain to determine if there is a direct link between PGE2 and MMP-9 induction in ICH. He plans to combine his previous research experience and knowledge of MMPs with the recently characterized roles of the respective PGE2 receptors in ICH.

Lab

Selected Publications

  1. Wang J, Tsirka SE. "Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral hemorrhage." Brain 128:1622–33, 2005.
  2. Wang J, Doré S. "Heme oxygenase-1 exacerbates early brain injury after intracerebral hemorrhage." Brain 130:1643–52, 2007.
  3. Wu H, Zhang Z, Hu X, Zhao R, Song Y, Ban X, Qi J, Wang J. "Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem study." Brain Res 1342:111–7, 2010.
  4. Wu H, Li Y, Zhao R, Li H, Song Y, Qi J, Wang J. "Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema." Neurochem Int 57:248–53, 2010.
  5. Wang J. "Preclinical and clinical research on inflammation after intracerebral hemorrhage."Prog Neurobiol 92:463–77, 2010.
  6. Wu H, Wu T, Xu X, Wang J, Wang J. "Iron toxicity in mice with collagenase-induced intracerebral hemorrhage." J Cereb Blood Flow Metab Nov 24, 2010.

Activities & Honors

Honors

  • Silver Medal Poster, Annual Anesthesiology and Critical Care Medicine Research Day, Johns Hopkins University School of Medicine, 2008 - 2009
  • American Heart Association Scientist Development Award, 2006 - 2008
  • National Science and Technology Advancement Award, Chinese Ministry of Education, 2005
  • American Heart Association Postdoctoral Fellowship, 2002 - 2004
  • Natural Science Award, Chinese Ministry of Education, 2003

Memberships

  • American Heart Association, 2002
  • American Society for Neuroscience, 2001
  • American Stroke Association, 2002
  • International Society for Cerebral Blood Flow and Metabolism
  • International Stroke Society, 2006

Professional Activities

  • Editorial board, Chinese Journal of Practical Nervous Diseases
  • Editorial board, Neural Regeneration Research
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