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Sangeeta Ray, M.S., Ph.D.

Photo of Dr. Sangeeta Ray, M.S., Ph.D.

Assistant Professor of Radiology and Radiological Science

Contact for Research Inquiries

Division of Nuclear Medicine and Molecular Imaging (DNMMI)
Russell H. Morgan Department of Radiology and Radiological Sciences
1550 Orleans Street
Baltimore, MD 21287 map

Background

Titles

  • Assistant Professor of Radiology and Radiological Science
  • Assistant Professor of Oncology

Education

Degrees

  • B.S., University of Burdwan (India) (1993)
  • M.S., Jadavpur University (India) (1995)
  • Ph.D., Jadavpur University (India) (1999)

Research & Publications

Lab

Sangeeta Ray is an inorganic and radiochemist with primary focus on developing necessary chemistry and bioconjugate techniques for important cellular and molecular targets.  Her specific research interest is directed towards the design and synthesis of metal-based imaging agents for positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance (MR), optical (fluorescence), as well as for multimodality imaging techniques.  With a major focus on prostate-specific membrane antigen (PSMA), she has designed and synthesized more than fifty agents for SPECT, PET, optical and MR imaging modality, many of those agents are first-in-class imaging agents.  She has received ‘Berson-Yalow Award’ from Society of Nuclear Medicine in 2011 for her comprehensive research showing effect chelating agents and linker functionality to optimize in vivo pharmacokinetics of 99mTc-labeled SPECT imaging agents targeting PSMA.  She received NIH career development grant for developing PSMA-targeted Gd-based MR contrast agents.  Currently, she has been focused on evaluating and optimizing several therapeutic radiometal-based agents including Lu-177, Bi-213, Pb-212 and Ac-225 for the imaging and treatment ('theranostics') for metastatic prostate cancer.

Selected Publications

View all on Pubmed

Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y, Fox JJ, Hilton J, Lupold SE, Kozikowski AP, Pomper MG. Synthesis and evaluation of technetium-99m-and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). J Med Chem. 2008;51:4504-4517. PMCID: PMC3336105.

Banerjee SR, Pullambhatla M, Byun Y, Nimmagadda S, Green G, Fox JJ, Horti A, Mease RC, Pomper MG. 68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer. J Med Chem. 2010;53:5333-5341. PMCID: PMC3341619.

Banerjee SR, Foss CA, Pullambhatla M, Wang Y, Srinivasan S, Hobbs RF, Nimmagadda S, Baidoo KE, Brechbiel M, Mease RC, Sgouros G, Pomper MG. Preclinical evaluation of 86Y-labeled inhibitors of prostate-specific membrane antigen for dosimetry estimates. J Nucl Med, 2015;56:628-634. PMCID: PMC4877701.

Banerjee SR, Ngen EJ, Rotz MW, Kakkad S, Lisok A, Pracitto R, Pullambhatla M, Chen Z, Shah T, Artemov D, Meade TJ, Bhujwalla, ZM, Pomper MG. Synthesis and evaluation of GdIII-based magnetic resonance contrast agents for molecular imaging of prostate-specific membrane antigen. Angew Chem Int Ed. 2015;4:10778-82. (Featured as Hot Topic). PMCID: PMC4729199

Banerjee SR, Pullambhatla M, Shallal H, Lisok A, Mease RC, Pomper MG. A modular strategy to prepare multivalent inhibitors of prostate-specific membrane antigen (PSMA). Oncotarget. 2011;2:1244-1253. PMCID: PMC3282081.

Patents

Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase IX (second generation)
Patent # JHU C14017 | 01/01/2016

Yang X, Minn I, Ray S, Rowe S, Gorin M, , Mease R, Allaf M, Pomper MG. 

Prostate-specific membrane antigen targeted high-affinity agents for endo radiotherapy of prostate cancer.
Patent # JHU C14083

Pomper MG, Ray S

PSMA targeted reversed carbamates and methods of use thereof.
Patent # WO 2016065145 A2 20160428. | 01/01/2016

Pomper MG, Mease RC, Ray S,Chen Y, Yang X, Attardo, Georgio.

New scaffolds and multifunctional intermediates for imaging psma and cancer therapy.
Patent # WO 2016065142 A2 20160428. | 01/01/2016

Pomper MG, Mease RC, Ray S,Chen Y, Yang X. 

Salicylic Acid-based Polymeric CEST Contrast agents for molecular imaging of prostate-specific membrane antigen.
Patent # C13062 | 01/01/2015

Yang X, Song X, Ray S, Pomper MG, McMahon M. 

Prostate-specific Membrane Antigen Targeted Plasmon-enhanced Raman Spectroscopy Reporters for Molecular Imaging of Prostate Cancer.
Patent # JHU C13637 | 01/01/2015

Barman I, Li M, Ray S, Pomper MG. 

Preparation of metal or radiometal-labeled urea- and carbamate-based PSMA inhibitors for PSMA-targeted imaging and radiotherapy.
Patent # WO 2015171792 A1 20151112 | 01/01/2015

Ray S,Pomper MG, Meade TJ, Mease RC, Chen Y, Yang X. 

PSMA-targeting compounds and uses thereof. United States Patent US2015/010438A
Patent # WO 2010108125 A2 20100923 | 01/01/2015

Pomper MG, Mease RC.; Ray S, Chen Y. 

Azole heterocycles for MRI contrast and pH sensing.
Patent # WO 2014186737 A1 20141120 | 01/01/2014

Yang X, Song X, Ray S, Pomper MG, McMahon M.

Salicylic acid, salicylic acid analogs and anthranilic acid derivatives for MRI contrast.
Patent # WO 2014182538 A1 20141113. | 01/01/2014

Yang X, Song X, Ray S, Pomper MG, McMahon M. 

Theranostic targeted nanoplexes which carry Multimodality imaging reporters together with target enzyme inhibitors, such as siRNAs and target prodrug enzymes, and their use in disease diagnosis and treatment.
Patent # US2014/0178399A1, WO 2012135592 A2 20121004 | 01/01/2014

Pomper MG, Bhujwalla Z, Chen Z, Li Cong, Nimmagadda S, Penet M-F; Ray, S

New homomultivalentevd heteromultivalent inhibitors of prostate specific membrane antigen (PSMA)
Patent # WO 2013082338 A1 20130606 | 01/01/2013

Pomper MG, Mease RC.; Ray S, Shallal, H. 

PSMA-targeted nanoparticles for therapy of prostate cancer.
Patent # US2011/02006779 | 01/01/2009

Chandran SS, Ray S, Denmeade SR, Pomper MG, Mease RC.

Labeled inhibitors of prostate specific membrane antigen (PSMA), biological evaluation, and use as imaging agents
Patent # 9,044,468, WO2009/002529. | 01/01/2008

Pomper MG, Ray S, Mease RC, Foss C.

Activities & Honors

Honors

  • Berson-Yalow Award, Society of Nuclear Medicine, 2011
  • Career Development Award, NIH NCI, 2011
  • Career Development Award, Patrick Walsh Research foundation, 2015
  • Travel stipend for the abstract “Gd-Based Magnetic Resonance Probes for Imaging Prostate Specific Membrane Antigen (PSMA), WMIC, 2013
  • “Dr. and Mrs. Peter S. Bing Scholar”, Patrick C. Walsh Prostate Cancer Research Fund, 2015

Memberships

  • Member of the SNMMI WINM Program Working Group, 2016 - 2017
  • American Chemical Society, 2011
  • Society of Nuclear Medicine, 2011
  • World Molecular Imaging Society, 2011
  • American Association of Cancer Research, 2011
  • Society of Radiopharmaceutical Science, 2011

Professional Activities

  • Journal Reviewing Activities
    Journal of Nuclear medicine (2015-current); Journal of Medicinal Chemistry (2008-current) Nuclear Medicine and Biology (2009-current); Molecular Imaging (2009-current); The Prostate (2010-current); Applied Radiation and Isotopes (2012-current); International Journal of Molecular Imaging (2012-current); Molecular Pharmaceutics (2015-current); Journal of Radioanalytical and Nuclear Chemistry (2013-current); Bioconjugate Chemistry (2015-current); Molecules (2015-current); Biomaterials (2016-current); Journal of Labelled Compounds and Radiopharmaceuticals (2016-current).
  • Editorial Activity
    Associate Editorial Board, American Journal of Nuclear Medicine and Molecular Imaging (2011-current)
  • Grant review
    Prostate Cancer UK; Tobacco-Related Disease Research Program, University of California
  • Abstract reviewer
    World Molecular Imaging Congress (WMIC), 2009-2012, 2014-current

Videos & Media

Lectures and Presentations

  • Metal-based prostate-specific membrane antigen (PSMA) inhibitors and their potential for cancer diagnosis and therapy.
    Presentation , ICMIC Seminar Series , Baltimore, MD (09/30/2009)
    Johns Hopkins University
  • Radiometal-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer
    Presentation , ICMIC Seminar Series , Baltimore, MD (10/16/2011)
    Johns Hopkins University
  • Design and synthesis of radiopharmaceuticals for SPECT Imaging. In vivo preclinical imaging: An introductory workshop
    Workshop , Society of Nuclear Medicine , Baltimore, MD (03/12/2012)
    Johns Hopkins University
  • Prostate-specific membrane antigen-based compounds for imaging and therapy of prostate cancer
    Presentation , ICMIC Seminar Series , Baltimore, MD (10/11/2012)
    Johns Hopkins University
  • PSMA Targeted Gd-Based MR/PET Contrast Agents for Imaging Prostate Cancer
    Presentation , NCI Alliance for Nanotechnology in Cancer , Houston, TX (10/17/2012)
    NCI Alliance for Nanotechnology in Cancer
  • Design and synthesis of radiometal-based imaging agents for prostate-specific membrane antigen (PSMA)
    Presentation , Chemistry Club , Baltimore, MD (01/08/2013)
    Brain Science Institute, Johns Hopkins University
  • Design and synthesis of radiopharmaceuticals for SPECT imaging. In vivo preclinical imaging: An introductory workshop, (Session Chair),
    Workshop , Baltimore, MD (03/11/2014)
    Society of Nuclear Medicine
  • Synthesis and evaluation of gadolinium-based contrast agents for MR imaging of prostate-specific membrane antigen (PSMA)
    Presentation (04/30/2014)
    ICMIC Seminar Series
  • Prostate-specific membrane antigen targeted nanoparticles for imaging and therapy of prostate cancer
    Presentation , National Science and Technology Innovation (Cancer Nanotechnology) Symposium , Gaylord Convention Center, Gaylord, MD (06/16/2014)
    TechConnect World 2014
  • Gd-Based MR Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen
    Presentation , 62nd SNMMI Annual Meeting , Baltimore, MD (06/08/2015)
    SNMMI
  • Low-molecular weight radiolabeled theranostic agents for metastatic castration- resistant prostate cancer
    Presentation , 11th Annual Johns Hopkins Prostate Research Day , Baltimore, MD (10/18/2016)
    Johns Hopkins University

Recent News Articles and Media Coverage

2015, SNM Scientific Press release on PSMA-based MR Imaging abstract at SNM annual meeting at Baltimore, MD.

2015, “Dr. and Mrs. Peter S. Bing Scholar”, Patrick C. Walsh Prostate Cancer Research Fund.

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