Dr. Popel's research focuses on the following areas:
Systems Biology of Angiogenesis - Angiogenesis is important in diverse areas such as cancer, cardiovascular disease, arthritis, diabetes, wound healing and tissue engineering. Dr. Popel and his research team are interested in the quantitative understanding of the mechanisms of microvascular network formation under different conditions. Using methods of computational and mathematical biology, they analyze the signaling pathways leading to angiogenesis as well as the cellular mechanisms governing tubulogenesis and network formation.
Blood Flow and Molecular Transport in the Microcirculation - Dr. Popel's lab is formulating computational models of the microcirculation based on anatomical, biophysical and physiological experimental data. These include detailed models of microcirculatory blood flow and molecular transport (e.g., oxygen and nitric oxide) and their regulation, and creation of databases of parameters necessary for model input and validation.
Electromechanical Transduction in the Cochlear Outer Hair Cell - Outer hair cells perform exquisite electromechanical transduction at acoustic frequencies and exhibit a unique form of cell motility. The motility is attributed to membrane-based molecular motors driven by changes in the transmembrane potential. Dr. Popel's lab develops biophysically based computational models of cell mechanics, molecular transport and cell electromotility at the microscopic and nanoscopic (molecular) scales.
Multiscale modeling has emerged in recent years as a powerful methodology to integrate the different levels of biological organization spanning multiple spatial and temporal scales. Dr. Popel and his research team apply the methods of multiscale modeling to problems of cancer and cardiovascular disease.
- Imoukhuede PI, Popel AS. "Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts." Cancer Med. 2014 Apr;3(2):225-44. doi: 10.1002/cam4.188. Epub 2014 Jan 22.
- Stamatelos SK, Kim E, Pathak AP, Popel AS. "A bioimage informatics based reconstruction of breast tumor microvasculature with computational blood flow predictions." Microvasc Res. 2014 Jan;91:8-21. doi: 10.1016/j.mvr.2013.12.003. Epub 2013 Dec 14.
- Vempati P, Popel AS, Mac Gabhann F. "Extracellular regulation of VEGF: Isoforms, proteolysis, and vascular patterning." Cytokine Growth Factor Rev. 2014 Feb;25(1):1-19. doi: 10.1016/j.cytogfr.2013.11.002. Epub 2013 Nov 27. Review.
- Logsdon EA, Finley SD, Popel AS, Gabhann FM. "A systems biology view of blood vessel growth and remodelling." J Cell Mol Med. 2013 Nov 17. doi: 10.1111/jcmm.12164. [Epub ahead of print]
- Tan WH, Popel AS, Mac Gabhann F. "Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking." Cell Signal. 2013 Dec;25(12):2496-510. doi: 10.1016/j.cellsig.2013.08.015. Epub 2013 Aug 29.