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Chang-Chia Liu, M.S., Ph.D.

Photo of Dr. Chang-Chia Liu, M.S., Ph.D.

Assistant Professor of Neurosurgery

Research Interests: Computational Biology; Bioinformatics


Dr. Chang-Chia Liu joined the Department of Neurosurgery at the Johns Hopkins University School of Medicine as an Assistant Professor in the Summer of 2012. Dr. Liu focuses his research on Human central nerve system, Electrophysiology, Computational neuroscience, Cognitive neuroscience, Multivariate signal processing and Data mining. He has developed analytical models to understand complex problems such as how painful senseations are generated in the brain, how painful senseation is modulated by attention and distraction and how fear memory is produced in human.

Prior to his academic career at the Johns Hopkins University School of Medicine, he was a research assistant in the Brain Dynamics Laboratory at the University of Florida. more


  • Assistant Professor of Neurosurgery

Departments / Divisions



  • B.S., Da-Yeh University (Taiwan) (2000)
  • M.S., University of Florida (Florida) (2004)
  • Ph.D., University of Florida (Florida) (2008)

Research & Publications

Selected Publications

Google Scholar Citations Link

  1. Liu CC, Veldhuijzen DS, Ohara S, Winberry J, Greenspan JD, Lenz FA (2011) Spatial attention to thermal pain stimuli in subjects with visual spatial hemi-neglect: extinction, mislocalization and misidentification of stimulus modality. Pain 152:498-506. PMID: 21111534 Commentary by Vale'ry Legrain (2011) Where is my pain?. Pain152: 467-468. PMID: 21126820
  2. Liu CC, Shi CQ, Franaszczuk PJ, Crone NE, Schretlen D, Ohara S, Lenz FA (2011) Painful laser stimuli induce directed functional interactions within and between the human amygdala and hippocampus. Neuroscience 178:208-217. PMID: 21256929
  3. Liu CC, Ohara S, Franaszczuk PJ, Lenz FA (2011) Attention to painful cutaneous laser stimuli evokes directed functional connectivity between activity recorded directly from human pain-related cortical structures. Pain 152:664-675. PMID: 21255929
  4. Liu CC, Ohara S, Franaszczuk PJ, Crone NE, Lenz FA (2011) Attention to painful cutaneous laser stimuli evokes directed functional interactions between human sensory and modulatory pain-related cortical areas. Pain 152:2781-2791. PMID: 22033363
  5. Liu CC, Franaszczuk P, Crone NE, Jouny C, Lenz FA (2011) Studies of properties of "Pain Networks" as predictors of targets of stimulation for treatment of pain. Front Integr Neurosci 5:80. PMID: 22164137
  6. Liu CC, Crone NE, Franaszczuk PJ, Cheng DT, Schretlen DS, Lenz FA (2011) Fear conditioning is associated with dynamic directed functional interactions between and within the human amygdala, hippocampus, and frontal lobe. Neuroscience 189:359-369. PMID: 21664438
  7. Liu CC, Ohara S, Franaszczuk P, Zagzoog N, Gallagher M, Lenz FA (2010) Painful stimuli evoke potentials recorded from the medial temporal lobe in humans. Neuroscience 165:1402-1411. PMID: 19925853

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