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Seulki Lee, Ph.D.

Photo of Dr. Seulki Lee, Ph.D.

Assistant Professor of Radiology and Radiological Science

Research Interests: Role of TRAIL signaling in fibrosis and cancer

Background

Dr. Seulki Lee is Assistant Professor of Radiology and Radiological Science, Ophthalmology and Materials Science and Engineering. His research group focuses on exploring novel TNF-related apoptosis-inducing ligand (TRAIL) signaling in fibrosis diseases and cancer for the development of novel TRAIL-based therapies and imaging. Dr. Lee is an expert in drug and protein drug delivery, nanotechnology and molecular imaging leading to more than 120 articles in peer-reviewed journals and 20 patents for drug/protein deliver and diagnostic imaging methods. 

Prior to joining Johns Hopkins, Dr. Lee was the inaugural section leader of the Theranostic Nanomedicine Section at the National Institute of Biomedical Imaging and Bioengineering (NIBIB/NIH). Currently, his team is evolving its research endeavors from drug delivery to explore TRAIL biology in fibrosis and cancer towards clinical translation. 

Dr. Lee has received multiple awards, including the NRC Associateship from the National Academy of Sciences, the NIH Pathway to Independence Award (K99/R00), Career Development Award and Investigator-Initiated Research Award from the Department of Defense and the Maryland Innovation Initiative Award. 

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Titles

  • Assistant Professor of Radiology and Radiological Science
  • Assistant Professor of Ophthalmology

Departments / Divisions

Education

Degrees

  • B.S., Sungkyunkwan University (South Korea) (2002)
  • Ph.D., Gwangju Institute of Science and Technology (South Korea) (2006)

Additional Training

Department of Radiology, Stanford School of Medicine, Stanford, CA, 2009, Postdoctoral Fellow; Biomedical Research Center, KIST, Seoul, South Korea, 2008, Research Fellow

Research & Publications

Selected Publications

Lee S, Choi KY, Jung HJ, Ryu JH, Lee A, Youn IC, Park JH, Kim IS, Kim SY, Chen X, Choi K, Kwon IC, Kim K, Real-time, high resolution video imaging of apoptosis in single cells with a polymeric nanoprobe. Bioconjugate Chemistry. 2011; 22(2): 125-131. PMID: 21218786

Kim TH, Swierczewska M, Oh Y, Kim A, Jo DG, Park JH, Byun Y, Sadegh-Nasseri S, Pomper MG, Lee KC, Lee S, Mix to validate: a facile, reversible PEGylation for fast screening of potential therapeutic proteins in vivo. Angewandte Chemie International Edition. 2013; 52(27): 6880-6884. [Cover feature] PMID: 23740787

Oh Y, Ogyi Park, Swierczewska M, Hamilton JO, Park JS, Kim TH, Lim SM, Eom H, Jo DG, Lee CE, Kechrid R, Mastorakos P, Zhang C, Hahn SK, Jeon OC, Byun R, Ki K, Hanes J, Lee KC, Pomper MG, Gao B, Lee S, Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells. Hepatology, 2015 Dec 28. Doi: 10.1002/hep.28432 PMID: 26710118

Oh Y, Swierczewska M, Kim TH, Lim SM, Eom HN, Park JH, Na DH, Kim K, Lee KC, Pomper MG, Lee S, Delivery of tumor-homing TRAIL sensitizer with long-acting TRAIL as a therapy for TRAIL-resistant tumors. Journal of Controlled Release, 2015; 220(Pt B): 671-81. PMID: 26381901

Swierczewska M, Han HS, Kim K, Park JH, Lee S, Polysaccharide-based nanoparticles for theranostic nanomedicine. Advanced Drug Delivery Reviews, 2016, 99(Pt A): 70-84. PMID: 26639578

Activities & Honors

Honors

  • NRC Associateship (NIH/NIST Fellowship, National Academy of Sciences, 2010
  • WMIC travel award, 2009
  • NRC Associateship (Fellowship), NIH/NIST , 2010
  • Pathway to Independence Award (K99/R00), National Academy of Sciences NIH , 2011
  • Guest Editor, Theranostics, 2012
  • Pilot Project Award, CCNE , 2013
  • Maryland Stem Cell Commission Grant, JHU , 2013
  • Career Development Award 2014, Department of Defense
  • Investigator-Initiated Research Award 2015, Department of Defense
  • Maryland Innovation Initiative Award 2016
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