Dr. Bottomley’s research focuses on the application of nuclear magnetic resonance (NMR) techniques to biophysical, biological and medical problems. He pursues the theoretical, experimental and technical development of NMR imaging (MRI); the development of methods for spatially localized spectroscopy (MRS) and the measurement of relaxation times, diffusion constants, metabolite concentrations, kinetic reaction rates, energy supply and work in biological tissues using NMR. He’s also interested in the application of these technologies to the noninvasive study of human disease, especially heart disease.
Specifically, Dr. Bottomley researches the effects of measurements of energy metabolites and metabolic fluxes with phosphorus (31P) and proton (1H) MRS in patients with ischemia, infarction and heart failure as well as sodium (23Na) MRI in patients with ischemic disease, and with cancer. Additionally, he investigates measurements of energy metabolites and metabolic fluxes with phosphorus (31P) and proton (1H) MRS in patients with ischemia, infarction and heart failure; sodium (23Na) MRI in patients with ischemic disease, and with cancer; stress testing for ischemia using 31P MRS; MRI detector coil design, phased-array detector coils including new strip detectors; and the development of new intravascular and internal MRI coils for imaging vascular and endothelial disease, and MRI-guided therapy delivery.
- Qian D, El-Sharkawy AEM, Atalar E, Bottomley PA. "Interventional MRI: Tapering Improves the Forward-Looking Properties of the Loopless Antenna." Magn Reson Med 2010; 63: 797-802. NIHMSID # 190764
- Ruiz-Cabello J, Barnett BP, Bottomley PA, Bulte JWM. "Fluorine (19F) MRS and MRI indicine." NMR in Biomedicine 2010 (in press).
- Schar M, El-Sharkawy AEM, Weiss RG, Bottomley PA. "Triple Repetition Time Saturation Transfer (TRiST) 31P Spectroscopy for Measuring Human Creatine Kinase Reaction Kinetics." Magn Reson Med 2010; 63: 1493-1501.
- Bottomley PA, Kumar A, Edelstein WA, Allen JM, Karmarkar PV. "Designing passive MRI-safe implantable conducting leads with electrodes." Med Phys 2010; 37: 3828-3843.
- Sathyanarayana S, Schar M, Kraitchman DL, Bottomley PA. "Real time MRI Endoscopy." J Am Coll. Cardiol. Cardiovasc. Imag (in press, 2010).