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Photo of Dr. Paul A. Bottomley, Ph.D.

Paul A. Bottomley, Ph.D.

Director, Division of MR Research
Professor of Radiology and Radiological Science

Male

Titles

  • Director, Division of MR Research
  • Professor of Radiology and Radiological Science
  • Professor of Biomedical Engineering
  • Professor of Medicine

Departments

Research Interests

New biomedical imaging modalities; Molecular imaging; High-speed cardiovascular NMR imaging

Biography

Dr. Paul Bottomley is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. He is also a Professor of Medicine in the Division of Cardiology School of Medicine, a Professor in the Biomedical Engineering School of Medicine and a Professor in Electrical and Computer Engineering. Dr. Bottomley serves as the Director of MR Research. His research focuses on the development and evaluation of magnetic resonance (MR) techniques.

Dr. Bottomley received his undergraduate degree in physics at Monash University, Victoria, Australia, and earned his Ph.D. in Physics and NMR imaging at Nottingham University in England. He was awarded the Coolidge Fellowship in MRC Magnetic Resonance Unit at John Radcliffe Hospital in 1993. Dr. Bottomley joined the Johns Hopkins faculty in 1994.

Prior to joining Johns Hopkins, Dr. Bottomley participated in the building and testing of perhaps the first human MRI system in Nottingham, England.

He is a member of the Board of Directors for Surgi-Vision Inc. and the International Society of Magnetic Resonance in Medicine. Dr. Bottomley was awarded the Society of Magnetic Resonance in Medicine''s Gold Medal for his contributions to MRI in 1989. He has published about 170 peer-reviewed papers and holds more than 30 patents.

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    Additional Information

  • Education +

    Additional Training

    MRC Magnetic Resonance Unit, John Radcliffe Hospital and Department of Biochemistry, Oxford University, Oxford, U.K., 1993, Coolidge Fellowship
  • Research & Publications +

    Research Summary

    Dr. Bottomley’s research focuses on the application of nuclear magnetic resonance (NMR) techniques to biophysical, biological and medical problems. He pursues the theoretical, experimental and technical development of NMR imaging (MRI); the development of methods for spatially localized spectroscopy (MRS) and the measurement of relaxation times, diffusion constants, metabolite concentrations, kinetic reaction rates, energy supply and work in biological tissues using NMR. He’s also interested in the application of these technologies to the noninvasive study of human disease, especially heart disease.

    Specifically, Dr. Bottomley researches the effects of measurements of energy metabolites and metabolic fluxes with phosphorus (31P) and proton (1H) MRS in patients with ischemia, infarction and heart failure as well as sodium (23Na) MRI in patients with ischemic disease, and with cancer. Additionally, he investigates measurements of energy metabolites and metabolic fluxes with phosphorus (31P) and proton (1H) MRS in patients with ischemia, infarction and heart failure; sodium (23Na) MRI in patients with ischemic disease, and with cancer; stress testing for ischemia using 31P MRS; MRI detector coil design, phased-array detector coils including new strip detectors; and the development of new intravascular and internal MRI coils for imaging vascular and endothelial disease, and MRI-guided therapy delivery.

    Selected Publications

    1. Qian D, El-Sharkawy AEM, Atalar E, Bottomley PA. "Interventional MRI: Tapering Improves the Forward-Looking Properties of the Loopless Antenna." Magn Reson Med 2010; 63: 797-802. NIHMSID # 190764
    2. Ruiz-Cabello J, Barnett BP, Bottomley PA, Bulte JWM. "Fluorine (19F) MRS and MRI indicine." NMR in Biomedicine 2010 (in press).
    3. Schar M, El-Sharkawy AEM, Weiss RG, Bottomley PA. "Triple Repetition Time Saturation Transfer (TRiST) 31P Spectroscopy for Measuring Human Creatine Kinase Reaction Kinetics." Magn Reson Med 2010; 63: 1493-1501.
    4. Bottomley PA, Kumar A, Edelstein WA, Allen JM, Karmarkar PV. "Designing passive MRI-safe implantable conducting leads with electrodes." Med Phys 2010; 37: 3828-3843.
    5. Sathyanarayana S, Schar M, Kraitchman DL, Bottomley PA. "Real time MRI Endoscopy." J Am Coll. Cardiol. Cardiovasc. Imag (in press, 2010).
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Commonwealth University Scholarship, 1972
    • Grant Reviewer, NIH, 1979 - 2003
    • Elected Trustee, Soc Magn Reson Med (1986-1989), 1982 - 1986
    • Associate Editor, Magn Reson Med, 1983
    • GE Dushman Award, 1983
    • Editorial boards member,  Rev Sci Instrum, 1986 - 1988
    • Editors recognition awards from Radiology, 1986 - 1990
    • Fellow, Soc Magn Reson, 1989
    • Gold Medal, Society for Magnetic Resonance in Medicine, 1989
    • Patent Medallions, GE gold (1989), 1989
    • GE Coolidge Fellow and Medal, 1990
    • Associate Editor, Radiology, 1991 - 1995
    • Editorial boards member,  Advanced Medicine, 1995

    Memberships

    • International Society of Magnetic Resonance in Medicine
    • Member, Board of Directors, Surgi-Vision Inc, 1998
  • Videos & Media +
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