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Shiv Saidha, MBBCh

Assistant Professor of Neurology
Male
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410-614-1522

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Johns Hopkins Outpatient Center

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Titles

  • Assistant Professor of Neurology

Expertise

Multiple Sclerosis, Neuroimmunology, Neurology

Research Interests

Dr. Saidhas research interests to date have predominantly focused on the non-invasive interrogation of retinal structures using optical coherence tomography (OCT) in multiple sclerosis (MS), in order to identify and investigate novel outcome strategies for assessing and monitoring neuroprotection and neurorestoration in MS, as well as to further our understanding of the pathobiology of MS, including how retinal pathology in MS may be related to more global central nervous system disturbances. He has been at the fore of discovering and demonstrating that inner and outer retinal layer pathology occur within the unmyelinated retina in MS (both quantitatively and qualitatively). He is committed to continuing to delineate and ascertain the mechanisms involved in the development of these findings, the clinical relevance of these changes (both locally in the retina, as well as more globally), and determine if this information may be used to guide the development of new, and potentially unique/novel effective MS therapies. His work to date has been primarily structurally focused (both within the retina using OCT, as well as more globally within the central nervous system through the assessment of brain substructure volumes, diffusion tensor imaging & magnetization transfer ratio metrics within specific pathways in MS).

Biography


Dr. Shiv Saidha specializes in the diagnosis, management, and treatment of multiple sclerosis (MS), as well as other neuroimmunological disorders of the central nervous system, including those afflicting the brain, spinal cord, and optic nerves.

Dr. Saidha received his medical degree, as well as his postgraduate Doctor of Medicine, from the National University of Ireland, Galway (NUIG), Ireland. He completed residency training in general internal medicine at Galway University Hospitals, Ireland. Subsequent to this he completed residency training in neurology at Galway, Cork, and Beaumont (located in Dublin) University Hospitals, Ireland. He then completed a further three years of specialized fellowship training in neuroimmunology & neuroinfectious diseases at Johns Hopkins University School of Medicine, Baltimore, Maryland.

Dr. Saidha’s research interests to date have predominantly focused on the non-invasive interrogation of retinal structures using optical coherence tomography (OCT) in multiple sclerosis (MS), in order to identify and investigate novel outcome strategies for assessing and monitoring neuroprotection and neurorestoration in MS, as well as to further our understanding of the pathobiology of MS, including how retinal pathology in MS may be related to more global central nervous system disturbances. He has been at the fore of discovering and demonstrating that inner and outer retinal layer pathology occur within the unmyelinated retina in MS (both quantitatively and qualitatively). He is committed to continuing to delineate and ascertain the mechanisms involved in the development of these findings, the clinical relevance of these changes (both locally in the retina, as well as more globally), and determine if this information may be used to guide the development of new, and potentially unique/novel effective MS therapies. His work to date has been primarily structurally focused (both within the retina using OCT, as well as more globally within the central nervous system through the assessment of brain substructure volumes, diffusion tensor imaging & magnetization transfer ratio metrics within specific pathways in MS). He also has expertise in the functional assessment of the anterior visual pathway in MS through the application of multifocal electroretinography and pupillometry techniques amongst others. He has published first author papers in Lancet, Lancet Neurology, Brain, Neurology, JAMA neurology, Archives of Neurology and Multiple Sclerosis Journal amongst authors.

Languages

  • English
  • French
  • German
  • Irish

Memberships

 

- Member of the American Academy of Neurology (AAN)

- Member of the New York Academy of Sciences (NYAS)

- Regular reviewer for Journal of Neurology, Neurosurgery & Psychiatry (JNNP), Journal of Neurology, European Journal of Neurology, PLoS ONE

Additional Resources +
  • Education +

    Training

    • National University of Ireland School of Medicine (Galway) (2004)

    Residencies

    • Merlin Park Hospital / Nephrology (Galway) (2007)
    • Merlin Park Hospital / Respiratory Therapy (Galway) (2007)
    • University College Hospital / Infectious Diseases (Galway) (2006)
    • University College Hospital / Medical Oncology (Galway) (2006)
    • University College Hospital / Neurology (Galway) (2006)
    • Merlin Park Hospital / Rheumatology (Galway) (2005)
    • University College Hospital / Endocrinology (Galway) (2005)

    Fellowships

    • Beaumont Hospital / Neurology (Dublin 9) (2013)
    • Johns Hopkins University School of Medicine / Neurology (Baltimore MD ) (2012)
    • University College Hospital / Neurology (Galway) (2009)
    • Cork University Hospital (CorkIreland) (2008)
    • Cork University Hospital / Clinical Neurophysiology (CorkIreland) (2008)
    • Mercy University Hospital / Neurology (Cork) (2008)
    • Cork University Hospital / Neurology (CorkIreland) (2007)
  • Research & Publications +

    Selected Publications

     Peer-reviewed Publications

     

    1. S. Saidha, M. Elamin, G. Mullins, E. Chaila, V. J. Tormey, M. J. Hennessy. Treatment of progressive encephalomyelitis with rigidity and myoclonic jerks with rituximab: a case report (European journal of neurology, 2008 May; 15(5):e33)

     

    1. S. Saidha, R. Renganathan, J. Spillane, B. McNamara, N. Fanning, A.M. Ryan. Simultaneous transverse myelitis and acute motor axonal neuropathy in an adult (Journal of neurology, neurosurgery and psychiatry, 2008 Nov; 79(11): 1302-3)

     

    1. S. Saidha, T. Mok, M. Butler, C. Keohane, H. Harrington. Bilateral brachial neuropathy and acute aortic dissection due to giant cell arteritis(Journal of neurology 2009 Aug; 256(8): 1346-8)

     

    1. G. Mullins, M. Elamin, S. Saidha, E. Ali, L. Jennings, T. Counihan, M. Hennessy. Acute aseptic meningitis and diffuse myelitis as the presenting features of neurological Behcet disease(Journal of clinical neurosciences, 2009 Dec; 16(12): 1702-4)

     

    1. S. Saidha, S. Murphy, P. McCarthy, P. Mayne, M. Hennessy. L-2-Hydroxyglutaric aciduria diagnosed in an adult presenting with acute deterioration(Journal of neurology, 2010 Jan; 257(1): 146-8)

     

    1. S. Saidha, J. Spillane, G. Mullins, B.McNamara. Spectrum of peripheral neuropathies associated with neurological interventions; A neurophysiological assessment(Journal of brachial plexus and peripheral nerve injury 2010 Apr; 5: 9)

     

    1. S. Saidha, T. Mok, M. Butler, N. Fanning, H. Harrington. Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone; a case report(Journal of clinical neuroscience, 2010 May; 17(5): 654-5)

     

    1. S. Saidha, S. Murphy, A. Ronayne, P.McCarthy, M. Hennessy, T. Counihan. Treatment of anti-glutamic acid decarboxylase antibody-associated limbic encephalitis with mycophenolate mofetil. (Journal of Neurology, 2010 Jun; 257(6): 1035-8)

     

    1. S. Saidha, C. Eckstein, J. Ratchford. Optical Coherence Tomography as a marker of axonal damage in Multiple Sclerosis. (Current Medical Literature – Multiple Sclerosis 2010 Oct; 2(2): 33–43)

     

    1. S. Saidha, C. Eckstein, J. Ratchford. Optical Coherence Tomography for the detection of axonal damage in Multiple Sclerosis. (Current Medical Literature – Ophthalmology 2010 Oct; 20(3): 77–88)

     

    1. S. Saidha, C. Eckstein, J. Ratchford. Optical Coherence Tomography as a marker of axonal damage in Multiple Sclerosis. (International Journal of Clinical Reviews 2010 Oct; 10: 01)

     

    1. S. Saidha, N. Fanning, T. Counihan. Facial diplegia and deafness following a fall. (International journal of Emergency Medicine, 2010 Dec; 3 (4): 475–476)

     

    1. S. Saidha, S. Syc, M. Ibrahim, C. Eckstein, C. Warner, S. Farrell, J. Oakley, M. Durbin, S. Meyer, L. Balcer, E. Frohman, J. Rosenzweig, S. Newsome, J. Ratchford, Q. Nguyen, P. Calabresi. Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography.(Brain, 2011 Feb; 134(2): 518-33) (Article featured in F1000, MDLinx and Practical Neurology)

     

    1. J. Dineen, S. Saidha, B. McNamara, B. Plant, A.M. Ryan. Brachial neuritis masquerading as acute coronary syndrome(Irish Medical Journal, 2011 Mar; 180(1): 291-294)

     

    1. S. Syc, C. Warner, S. Saidha, S. Farrell, A. Conger, E. Bisker, J. Wilson, T. Frohman, E. Frohman, L. Balcer, P. Calabresi. Cup to disc ratio by optical coherence tomography is abnormal in multiple sclerosis. (Journal of Neurological Sciences, 2011 Mar; 302(1-2):19-24)

     

    1. L. Fullham, S. Saidha, H. Harrington, P. MacEneaney. Spontaneous intracranial hypotension(Irish journal of medical sciences, 2011 Jun; 180(2): 587-588)

     

    1. C. Eckstein, S. Syc, S. Saidha. Differential diagnosis of longitudinally extensive transverse myelitis in adults. (European Neurological Journal, 2011 July; 3(1): 27-39)

     

    1. C. Warner, S. Syc, A. Stankiewizc, G. Hiremath, S. Farrell, A. Conger, T. Frohman, E. Bisker, L. Balcer, E. Frohman, P. Calabresi, S. Saidha. The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials. (PLoS ONE, 2011;6(8):e22947)

     

    1. S. Saidha, S. Syc, M. Durbin, C. Eckstein, J. Oakley, S. Meyer, A. Conger, T. Frohman, S. Newsome, J. Ratchford, E. Frohman, P. Calabresi. Visual dysfunction correlates better with macular ganglion cell layer thickness than peripapillary retinal nerve fibre layer thickness as measured by optical coherence tomography. (Multiple Sclerosis Journal, 2011 Dec; 17(12):1449-63) (Article featured in MDLinx)

     

    1. S. Saidha, C. Eckstein, P. Calabresi. New and emerging disease modifying therapies for multiple sclerosis. (Annals of the New York Academy of Sciences, 2012 Jan; 1247:117-137)

     

    1. S. Syc, S. Saidha, S. Newsome, J. Ratchford, J. Oakley, M. Durbin, S. Meyer, E. Frohman, L. Balcer, P. Calabresi. Retinal segmentation of optical coherence tomography scans reveals ganglion cell layer pathology after acute optic neuritis. (Brain, 2012 Feb; 135(Pt 2):521-33)

     

    1. S. Saidha, E. Sotirchos, C. Eckstein. Etiology of sarcoidosis: Does infection play a role? (Yale Journal of Biology and Medicine, 2012 Mar; 85(1):133-141)

     

    1. C. Eckstein*, S. Saidha*, M. Levy (Co-First authors*). A differential diagnosis of central nervous system demyelination; beyond multiple sclerosis. (Journal of Neurology, 2011 Sep 20. [Epub ahead of print])

     

    1. C. Eckstein*, S. Saidha*, S. Syc, G. Byraiah, M. Seigo, A. Stankiewicz, E. Ford, E. Sotirchos. S. Sharma, P. Calabresi, C. Pardo (Co-First authors*). Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography. (Journal of Neurology, 2012 Jan 4. [Epub ahead of print])
    2. M. Seigo, E. Sotirchos, S. Newsome, A. Babiarz, C. Eckstein, E. Ford, J. Oakley, S. Syc, T. Frohman, J. Ratchford, L. Balcer, MD, E. Frohman, P. Calabresi, S. Saidha. In-vivo assessment of retinal neuronal layers in multiple sclerosis with manual and automated optical coherence tomography segmentation techniques. (Journal of Neurology, 2012 Mar 15 [Epub ahead of print])

     

    1. S. Saidha, C. Pardo. Spinal cord glioma metastasizing to the brain. (Archives of Neurology, 2012 Apr 23 [Epub ahead of print])

     

    1. E. Sotirchos, S. Saidha, D. Becker. Nitrous oxide-induced myelopathy with inverted V-sign on spinal MRI (Journal of neurology, neurosurgery and psychiatry, 2012 Jul 8 [Epub ahead of print])

     

    1. J. Oh, K. Zackowski, M. Chen, S. Newsome, S. Saidha, S. Smith, M. Diener-West, J. Prince, C. Jones, P. Zijl, P. Calabresi, D. Reich. MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis. (Multiple Sclerosis Jorunal, 2012 Aug 13 [Epub ahead of print])

     

    1. E. Sotirchos, M. Seigo, P. Calabresi, S. Saidha. Comparison of point estimates and average thicknesses of retinal layers measured using manual optical coherence tomography segmentation for quantification of retinal neurodegeneration in multiple sclerosis. (Current Eye Research, 2012 Sep 6 [Epub ahead of print])

     

    1. P. Blazek, S. Davis, B. Greenberg, A. Conger, D. Conger, S. Vernino, S. Beh, O. Stuve, S. Saidha, J. Ratchford, A. Green, P. Calabresi, L. Balcer, T. Frohman, E. Forhman. Objective characterization of the relative afferent papillary defect in MS. (Journal of Neurological Sciences, 2012 Sep 28 [Epub ahead of print])

     

    1. S. Saidha, E. Sotirchos, J. Oh, S. Syc, M. Seigo, N. Shiee, C. Eckstein, M. Durbin, J. Oakley, S. Meyer, T. Frohman, S. Newsome, J. Ratchford, L. Balcer, E. Frohman, D. Pham, C. Crainiceanu, D. Reich, P. Calabresi. Retinal axonal and neuronal changes in multiple sclerosis reflect global CNS pathology. (Archives of Neurology, 2012 Oct 1 [Epub ahead of print]) (Received editorial) (Article featured in JAMA podcast)

     

    1. S. Saidha, E. Sotirchos, M. Ibrahim, J. Gelfand, Y. Sepah, J. Ratchford, J. Oh, M. Seigo, S. Newsome, L. Balcer, E. Frohman, C. Crainiceanu, A. Green, Q. Nguyen, P. Calabresi. Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study. (Lancet Neurology, 2012 Oct 4 [Epub ahead of print]) (Received editorial)

     

    1. J. Ratchford*, S. Saidha*, E. Sotirchos, J. Oh, M. Seigo, C. Eckstein, M. Durbin, J. Oakley, S. Meyer, A. Conger, T. Frohman, S. Newsome, L. Balcer, E. Frohman, P. Calabresi (Co-First authors*). Clinical and radiological disease activity is associated with accelerated rates of retinal neurodegeneration in multiple sclerosis. (Neurology, 2013 Jan 1 [Epub ahead of print]) (Received editorial)

     

    1. J. Oh, E. Sotirchos, S. Saidha, M. Ibrahim, Y. Sepah, Q. Nguyen, P. Calabresi. In-vivo demonstration of homonymous hemimacular loss of retinal ganglion cells due to a thalamic lesion with optical coherence tomography. (Archives of Neurology, in press)

     

    1. J. Oh, S. Saidha, M. Chen, J. Prince, S. Smith, C. Jones, P. Zijl, D. Reich, P. Calabresi. Investigating the clinic-radiologic paradox using quantitative MRI of the spinal cord in multiple slcerosis. (Neurology, in press)

     

    1. E. Sotirchos, S. Saidha, G. Byraiah, M. Mealy, M. Ibrahim, Y. Sepah, S. Newsome, J. Ratchford, E. Frohman, L. Balcer, C. Crainiceanu, Q. Nguyen, M. Levy, P. Calabresi. In-vivo identification of morphologic retinal abnormalities in neuromyelitis optica. (Neurology, in press)

     

    1. S. Syc, D. Harrison, S. Saidha, M. Seigo, P. Calabresi, D. Reich. Quantitative MRI reveals abnormality of the fornix and cingulum in multiple sclerosis. (Multiple Sclerosis International, in press)

     

    Non peer-reviewed Publications

     

    1. S. Saidha, J. Dineen, A.M. Ryan. Data interpretation in neurology(Hospital doctor of Ireland, 2008 Oct)

     

    1. S. Saidha, S. Syc, L. Balcer, E. Frohman, P. Calabresi. Reply: Re: Retinal pathology in multiple sclerosis: insight into the mechanisms of neuronal pathology. (Brain, 2011 Jan;134(5):e172)

     

    1. S. Saidha, S. Syc, L. Balcer, E. Frohman, P. Calabresi. Reply: Re: Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. (Brain, 2011 May;134(11): e194)
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

     

    1. Winner of the Multiple Sclerosis International Federation (MSIF) prize for best oral presentation by a young investigator at ECTRIMS 2010
    2. Winner of the Michael J O’ Donnell 2008/2009 NUI Galway memorial prize for best post-graduate presentation in Medicine (“Stroke thrombolysis; An update, our experience & proposal for modified inclusion criteria”)
    3. Awarded ECTRIMS/RIMS 2010 Travel Grant in acknowledgement of the quality of scientific contribution to the congress
    4. Awarded ECTRIMS/RIMS 2011 Travel Grant in acknowledgement of the quality of scientific contribution to the congress
    5. Awarded ECTRIMS/RIMS 2012 Travel Grant in acknowledgement of the quality of scientific contribution to the congress
    6. Awarded Teva Neuroscience 2011 Educational Grant
    7. Director of the Johns Hopkins Neuroimmunology and neurological infections case conference program (1/7/10 – 30/6/12)
    8. Successfully completed 2 semesters of ‘Biostatistics in Public Health’ (2010/2011) at the Johns Hopkins Bloomberg School of Public Health
    9. Certified by Neurostatus for EDSS examination
    10. Medical Director for a Johns Hopkins School of Medicine accredited Continuing Medical Education program (“Advances in MS: Emerging strategies for neuroprotection and neuroregeneration”)
    11. Medical Director for a University of Medicine and Dentistry of New Jersey (UMDNJ) accredited Continuing Medical Education program (“Prognostic factors in MS: Practical considerations for treatment decisions”)

     

  • Videos & Media +

    Lectures and Presentations

     

    - In-vivo assessment of retinal axonal and neuronal integrity & pathology in MS with optical coherence tomography, Neurology Grand Rounds, Zurich University, 18 Dec 2012 (invited speaker)

    - A novel retinal phenotype in multiple sclerosis is predictive of inflammatory disease activity and disability progression, ECTRIMS, 10 Oct 2012

    - Optical Coherence Tomography as a Tool for Monitoring Changes and Treatment Effects in MS, New York Academy of Sciences Conference on Imaging Neurodegeneration and repair in MS, 15th June 2012 (invited expert speaker)

    - In-vivo assessment of retinal axonal and neuronal integrity in MS with optical coherence tomography, CMSC/ACTRIMS, 31 May 2012 (invited expert speaker)

    - Novel optical coherence tomography techniques in MS; Emerging evidence for primary retinal neuronal mechanisms of pathology, Neurology Grand Rounds, University of Texas Southwestern, 16 May 2012 (invited speaker)

    - Clinical and radiological disease activity is associated with accelerated rates of retinal ganglion cell layer degeneration in multiple sclerosis, AAN, 24 April 2012

    - Optical coherence tomography (OCT) of the eye; A window into the MS disease process, United States Project Restore Board Meeting, 30 March 2012 (invited expert speaker)

    - Cross-sectional relationships between retinal segmentation and brain sub-structure volumes in multiple sclerosis, ECTRIMS/ACTRIMS, 20 October 2011

    - Retinal neuronal loss in multiple sclerosis; Extending the utility of optical coherence tomography with retinal segmentation, AAN, 13 April 2011

    - Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography, ECTRIMS, 13 Oct 2010

    - Peri-procedural neuropathy; A retrospective review, RAMI registrar prize, Nov 2008

    - Another patient with a learning disability in decline? RAMI registrar prize, Nov 2008

    - Bilateral brachial neuropathy and an unexpected aortic dissection; A case report, Irish neuromuscular meeting, 10 May 2008

    - Multiple sclerosis presenting with parkinsonism; A case report, Irish neurological association 44th annual meeting, 8 May 2008

    - Transverse Myelitis and Acute Motor axonal neuropathy, RAMI registrar prize, Nov 2007

    - Progressive encephalomyelitis with rigidity and autoimmune polyglandular syndrome; A case report Irish neurological association 42nd annual meeting, 11 May 2006

  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    5th floor
    Baltimore, MD 21287
    Phone: 410-614-1522
    Appointment Phone: 410-614-1522
    Fax: 410-502-6736
    Location Map

    Department/Division

    • Neurology

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