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Jason P. Kirkness, Ph.D.

Jason Paul Kirkness, Ph.D.

Photo of Dr. Jason P. Kirkness, Ph.D.

Assistant Professor of Medicine

Research Interests: Asthma; COPD; Inhaled Medication; Nocturnal ventilation; Nasal High Flow Therapy; Sleep apnea


Dr. Jason Kirkness is an Assistant Professor of Medicine in the Pulmonary and Critical Care Medicine Department. Nationally recognized clinical researcher in medical device development from proof of concept through validation and regulatory approval in different sectors of the academic science and health care industry.

Dr. Kirkness holds a bachelor’s degree from the University of Western Sydney and a PhD from the University of Sydney. He completed fellowships at the University of Western Australia and the Johns Hopkins University School of Medicine before joining the faculty. 

Dr Kirkness has directed Innovation and commercialization of University‐based technology and intellectual property for $2b market in inhaled medication for chronic respiratory disease. Established a pathway for clinical researchers to translate fundamental findings into FDA‐approved and market‐ ready products. Led National award‐winning innovation team (NSF I‐Corps) focused on technology validation, customer development and value creation to contribute to commercialization. Received recognition for Faculty innovation leadership from Johns Hopkins School of Medicine. more


  • Assistant Professor of Medicine



  • B.Sc., University of Western Sydney (Australia) (1997)
  • Ph.D., University of Sydney (Australia) (2003)

Research & Publications

Technology Expertise Keywords

Inhaled medication usage; Nasal high flow therapy; Airway collapsing pressures, pneumotachography, polysomnography

Selected Publications

View all on Pubmed

  1. Kawai M, Kirkness JP, Yamamura S, Imaizumi K, Yoshimine H, Oi K, Ayuse T. Increased phosphatidylcholine concentration in saliva reduces surface tension and improves airway patency in obstructive sleep apnoea. J Oral Rehabil. 2013 Oct;40(10):758-66. doi: 10.1111/joor.12094. Epub 2013 Aug 30. PMID: 24033347
  2. Wei T, Erlacher MA, Grossman P, Leitner EB, McGinley BM, Patil SP, Smith PL, Schneider H, Schwartz AR, Kirkness JP. Approach for streamlining measurement of complex physiological phenotypes of upper airway collapsibility. Comput Biol Med. 2013 Jun;43(5):600-6. doi: 10.1016/j.compbiomed.2012.12.006. Epub 2013 Mar 18. PMID: 23517555
  3. Schwartz AR, Smith PL, Schneider H, Patil SP, Kirkness JP. Invited editorial on "Lung volume and upper airway collapsibility: what does it tell us about pathogenic mechanisms?". J Appl Physiol (1985). 2012 Sep 1;113(5):689-90. doi: 10.1152/japplphysiol.00716.2012. Epub 2012 Aug 2. No abstract available. PMID: 22858622
  4. Nilius G, Franke KJ, Domanski U, Rühle KH, Kirkness JP, Schneider H. Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure. Adv Exp Med Biol. 2013;755:27-34. PMID: 22826046
  5. Polotsky M, Elsayed-Ahmed AS, Pichard L, Harris CC, Smith PL, Schneider H, Kirkness JP, Polotsky V, Schwartz AR. Effects of leptin and obesity on the upper airway function. J Appl Physiol (1985). 2012 May;112(10):1637-43. doi: 10.1152/japplphysiol.01222.2011. Epub 2012 Feb 16. PMID: 22345430
  6. Kirkness JP, McGinley BM, Sgambati FP, Patil SP, Smith PL, Schwartz AR, Schneider H. Developing quantitative physiological phenotypes of sleep apnea for epidemiological studies. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:8319-22. doi: 10.1109/IEMBS.2011.6092051. PMID: 22256275
  7. Hernandez AB, Kirkness JP, Smith PL, Schneider H, Polotsky M, Richardson RA, Hernandez WC, Schwartz AR. Novel whole body plethysmography system for the continuous characterization of sleep and breathing in a mouse. J Appl Physiol (1985). 2012 Feb;112(4):671-80. doi: 10.1152/japplphysiol.00818.2011. Epub 2011 Dec 1. PMID: 22134700
  8. Chin CH, Kirkness JP, Patil SP, McGinley BM, Smith PL, Schwartz AR, Schneider H. Compensatory responses to upper airway obstruction in obese apneic men and women. J Appl Physiol (1985). 2012 Feb;112(3):403-10. doi: 10.1152/japplphysiol.00021.2011. Epub 2011 Nov 17. PMID: 22096117
  9. Schwartz AR, Schneider H, Smith PL, McGinley BM, Patil SP, Kirkness JP. Physiologic phenotypes of sleep apnea pathogenesis. Am J Respir Crit Care Med. 2011 Nov 15;184(10):1105-6. doi: 10.1164/rccm.201108-1573ED. No abstract available. PMID: 22086988
  10. Hoshino Y, Ayuse T, Kobayashi M, Kurata S, Kawai M, Schneider H, Patil SP, Schwartz AR, Kirkness JP, Oi K. The effects of hormonal status on upper airway patency in normal female subjects during propofol anesthesia. J Clin Anesth. 2011 Nov;23(7):527-33. doi: 10.1016/j.jclinane.2011.02.004. PMID: 22050795

Activities & Honors


  • 2016 Best Sleep Fragment Annals of the American Thoracic Society Publication, American Thoracic Society, 2016 - 2016
  • American Heart Association National Career Development Award, American Heart Association, 2012 - 2015
  • Asia Pacific Society for Respirology Career Development Award, Asia Pacific Society for Respirology, 2008 - 2008
  • John Read Prize for Physiological Research, Thoracic Society of Australia and New Zealand, 2007 - 2007
  • Westmead Millennium Institute Science Prize, Westmead Millennium Institute, 2006 - 2006
  • Thoracic Society of Australia & New Zealand Allen and Hanbury Travel, Thoracic Society of Australia & New Zealand, 2006 - 2006
  • CJ Martin Fellowship, National Health & Medical Research Council of Australia, 2005 - 2009
  • Thoracic Society of Australia & New Zealand Allen and Hanbury Overseas Fellowship, Thoracic Society of Australia & New Zealand, 2004 - 2005
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