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Narutoshi Hibino, M.D., Ph.D.

Photo of Dr. Narutoshi Hibino, M.D., Ph.D.

Assistant Professor of Surgery

Male

Languages: English, Japanese

Expertise: Aortic Root Replacement, Aortic Surgery, Aortic Valve Repair, Aortic Valve Sparing Root Replacement, Cardiac Surgery, Congenital Heart Disease, Congenital Heart Disease - Pediatric, Endovascular Aortic Surgery, Minimally Invasive Valve Surgery, Mitral Valve Repair, Pediatric Cardiac Surgery, Thoracic Aortic Aneurysms ...read more

Research Interests: Tissue engineering technology; tissue engineered vascular grafts and valves

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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-2800

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-2800

Johns Hopkins Outpatient Center

601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-955-2800

Background

Dr. Narutoshi Hibino has a wide range of experience treating patients with congenital heart disease. He has 15 years of subspecialty training in cardiac surgery that includes fellowships in both adult and pediatric cardiac surgery. He also works closely with the heart transplant and mechanical assist device teams. Dr. Hibino has an interest in translational research, particularly in applying the technology of tissue engineering into the cardiovascular field. He believes that bench-to-bedside research is fostering a new generation of medical innovations.

Dr. Hibino received his undergraduate and medical degrees in Ehime University, Japan. He completed cardiac and cardiovascular surgery fellowships and obtained board certifications at Tokyo Women’s Medical University, internationally recognized one of the top heart hospitals. Following a research fellowship for tissue engineering at Yale University, Dr. Hibino completed pediatric cardiac surgery fellowships at Children’s National Medical Center in Washington, D.C. and Nationwide Children’s Hospital in Columbus, Ohio before joining the faculty at Johns Hopkins University School of Medicine.

Dr. Hibino’s research interests involve healing the heart with patients’ own cells, growing vascular grafts and other items of repair through a process of tissue engineering. He has lectured nationwide on this topic. In a similar vein, Dr. Hibino’s philosophy of patient care is guided by evidence-based research and the belief that putting the patient first and providing an individualized care plan provides the best possible outcome.

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Titles

  • Assistant Professor of Surgery

Departments / Divisions

Education

Degrees

  • MD; Cardiac Surgery, Ehime University School of Medicine (1997)

Residencies

  • Ehime Prefectural Central Hospital / Cardiac Surgery (1999)

Fellowships

  • Tokyo Women's Medical University / Cardiac Surgery (1998)
  • Tokyo Women's Medical University / Cardiac Surgery (2000)
  • Yamanashi Prefecture Central Hospital / Cardiac Surgery (2001)
  • Tokyo Women's Medical University / Surgery (2002)
  • Nagano Children's Hospital / Cardiovascular Surgery (2003)
  • Children's National Medical Center / Cardiovascular Surgery (2012)
  • Nationwide Children's Hospital / Cardiothoracic Surgery (2014)

Research & Publications

Lab

Despite significant advances in surgical management for cardiovascular disease, one major source of morbidity and mortality arises from the use of synthetic biomaterials for various reconstructive cardiovascular operations. Tissue engineering technology offers a potential strategy for overcoming these complications by providing a biodegradable scaffold for the patient’s own cells to proliferate and provide physiologic functionality. 

Dr. Hibino’s lab focuses on the application of tissue engineering technology into the field of cardiovascular surgery. His research has shed light on the mechanism of neotissue formation of tissue engineered vascular graft. His team also has been developing a new generation of tissue engineered vascular grafts and valves through collaboration with bioengineering labs and industries. 

Recent progress in imaging technologies such as ultrasound, CT and MRI allows surgeons detailed, 3-D views of complex cardiac and vascular anatomy of cardiovascular disease before surgery. Such technology also offers significantly more utility with the advent of 3-D printing technology using proper biomaterials, which enables rapid, custom manufacturing. Dr. Hibino’s lab has been working for creation of patient-specific, tissue engineered vascular grafts constructed from pre-operative 3-D images using a computer aided design (CAD) model and 3-D printing technology.

Heart failure is one of the leading causes of death worldwide despite the variety of medical, mechanical, and surgical strategies. Many important issues remain to be resolved in recently developed alternative treatments such as stem cell therapy. Dr. Hibino’s lab another new project is the development of a scaffold-free multilayer functional engineered cardiac tissue created from cell spheroids consisting of iPS cell-derived cardiomyocytes, endothelial cells, pericytes, and fibroblasts using a “ Bio-3D printer”. This will constitutes a significant step towards a new generation of alternative stem cell treatment for heart failure.

Lab website: http://www.hopkinsmedicine.org/research/labs/hibino-lab

Lab Website: The Hibino Lab

Selected Publications

View all on Pubmed

Hibino N, McConnell P, Shinoka T, Malik M, Galantowicz M. Preliminary Experience in the Use of an Extracellular Matrix (CorMatrix) as a Tube Graft: Word of Caution. Semin Thorac Cardiovasc Surg. 2015 Autumn;27(3):288-95.

Melchiorri AJ, Hibino N, Best CA, Yi T, Lee YU, Kraynak CA, Kimerer LK, Krieger A, Kim P, Breuer CK, Fisher JP. 3D-Printed Biodegradable Polymeric Vascular Grafts. Adv Healthc Mater. 2016 Feb;5(3):319-25.

Hibino N, Best CA, Engle A, Ghimbovschi S, Knoblach S, Nath DS, Ishibashi N, Richard JA. Novel Association of miR-451 with the Incidence of TEVG Stenosis in a Murine Model. Tissue Eng Part A. 2015 2016 Jan;22(1-2):75-82.

Hibino N, Cismowski MJ, Lilly B, McConnell PI, Shinoka T, Cheatham JP, Lucchesi PA, Galantowicz ME, Trask AJ. Potential Molecular Mechanism of Retrograde Aortic Arch Stenosis in the Hybrid Approach to Hypoplastic Left Heart Syndrome. Ann Thorac Surg. 2015 Sep;100(3):1013-9

Hibino N, Mejias D, Pietris N, Dean E, Yi T, Best C, Shinoka T, Breuer C. The Innate Immune System Contributes to Tissue Engineered Vascular Graft Performance. FASEB J. 2015 Jun;29(6):2431-8.

Duncan DR, Chen PY, Patterson JT, Lee YU, Hibino N, Cleary M, Naito Y, Yi T, Gilliland T, Kurobe H, Church SN, Shinoka T, Fahmy TM, Simons M, Breuer CK. TGFβR1 Inhibition Blocks the Formation of Stenosis in Tissue-Engineered Vascular Grafts. J Am Coll Cardiol. 2015 Feb 10;65(5):512-4.

Melchiorri AJ, Hibino N, Yi T, Lee YU, Sugiura T, Tara S, Shinoka T, Breuer C, Fisher JP. Contrasting Biofunctionalization Strategies for the Enhanced Endothelialization of Biodegradable Vascular Grafts. Biomacromolecules. 2015 Feb 9;16(2):437-46.

Bracaglia LG, Li Y, Hibino N, Fisher JP. Reinforced Pericardium as a Hybrid Material for Cardiovascular Applications. Tissue Eng Part A. 2014 Nov;20(21-22):2807-16.

Hibino N, He D, Yuan F, Yu JH, Jonas R. Growth of Diminutive Central Pulmonary Arteries After Right Ventricle to Pulmonary Artery Homograft Implantation. Ann Thorac Surg. 2014 2014 Jun;97(6):2129-33.

Hibino N, Sinha P, Donofrio M, Jonas R. Reconstruction of cavopulmonary pathway for the patient with persistent arteriovenous malformations due to offset flow from hepatic vein. J Saudi Heart Assoc. 2012;24:51–54.

Hibino N, Duncan DR, Nalbandian A, Yi T, Qyang Y, Shinoka T, Breuer CK. Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts. J Thorac Cardiovasc Surg. 2012 Mar;143(3):696-703.

Hibino N, Yi T, Duncan DR, Rathore A, Dean E, Naito Y, Dardik A, Kyriakides T, Madri J, Pober JS, Shinoka T, Breuer CK. A critical role for macrophages in neovessel formation and the development of stenosis in tissue-engineered vascular grafts. FASEB J. 2011 Dec;25(12):4253-63.

Hibino N, Villalona G, Pietris N, Duncan DR, Schoffner A, Roh JD, Yi T, Dobrucki LW, Mejias D, Sawh-Martinez R, Harrington JK, Sinusas A, Krause DS, Kyriakides T, Saltzman WM, Pober JS, Shin'oka T, Breuer CK. Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel. FASEB J. 2011 Aug;25(8):2731-9.

Hibino N, Sinoka T, Breuer K. Restoring Blood Vessels. Tissue Engineering in Regenerative Medicine. Humana Press/ Springer, 2011.

Hibino N, McGillicuddy E, Matsumura G, Ichihara Y, Naito Y, Breuer CK, Shinoka T. Late-term results of tissue-engineered vascular grafts in humans. J Thorac Cardiovasc Surg. 2010; 139(2):431-6.

Hibino N, Shin'oka T, Matsumura G, Ikada Y, Kurosawa H. The tissue-engineered vascular graft using bone marrow without culture. J Thorac Cardiovasc Surg. 2005 May;129(5):1064-70.

Hibino N, Shin'oka T, Kurosawa H. Long-term histologic findings in pulmonary arteries reconstructed with autologous pericardium. New Engl J Med. 2003 Feb 27;348(9):865-7.

Activities & Honors

Memberships

  • American Heart Association
  • Tissue Engineering Society International
  • Japan Surgical Society
  • The Japanese Association for Thoracic Surgery
  • Japanese Society for Cardiovascular Surgery
  • Japanese Circulation Society

Videos & Media

Lectures and Presentations

  • Preclinical Study of Patient-Specific Cell-free Nanofiber TEVGs Using 3D Printing in a Sheep Model
    Presentation , 42th Annual Meeting of Western Thoracic Surgical Association , Waikoloa, Hawaii (06/25/2016)
  • Small-Diameter Tissue-Engineered Vascular Grafts Using Electrospun PCL/Chitosan Nanofiber Scaffolds in Sheep Model
    Presentation , The International Society for Applied Cardiovascular Biology 2015 European Meeting , Nuremberg, Germany (12/03/2015)
  • Preliminary experience in the use of an extracellular matrix (CorMatrix) as a tube graft: Word of Caution
    Presentation , AATS , Seattle, WA (04/01/2015)
  • Potential Molecular Mechanism of Retrograde Aortic Arch Stenosis in the Hybrid Approach to Hypoplastic Left Heart Syndrome
    Presentation , 51th Annual Meeting , San Diego, CA (01/01/2015)
    STS
  • Micro RNA 451 plays a role as suppressor of neointimal hyperplasia in tissue engineered vascular graft
    Presentation , 14th Biennial Meeting , Cleveland, OH (04/01/2014)
    International Society for Applied Cardiovascular Biology
  • Evaluation of the Use of an iPS Cell Sheet for the Construction of Tissue Engineered Vascular Grafts
    Presentation , 91st Annual Meeting , Philadelphia, PA (05/01/2011)
    AATS
  • Molecular Identity of Tissue Engineered Vascular Grafts
    Presentation , Orlando, FL (12/01/2010)
    Tissue engineering and Regenerative Medicine society (TERMIS) North America
  • Tissue Engineered Vascular Grafts: The Molecular Mechanism of Neotissue Creation
    Presentation , 12th Biennial Meeting , Boston, MA (09/01/2010)
    International Society for Applied Cardiovascular Biology
  • Autologous Bone Marrow Seeding in Tissue Engineered Vascular Grafts; a Murine Model Recapitulating the Results of a Clinical Trial
    Presentation , 46th Annual Meeting , Fort Lauderdale, FL (01/01/2010)
    STS
  • Tissue Engineered Vascular Grafts in Humans: Correlating Clinical Outcomes to Vascular Neotissue Formation in Mice
    Presentation , 89th Annual Meeting , Boston, MA (05/01/2009)
    AATS
  • A Novel System for the Separation of Mononuclear Cells from Human Bone Marrow for the Creation of Tissue Engineered Vascular Grafts
    Presentation , 2009 Meeting , San Diego, CA (05/01/2009)
    International Society for Cellular Therapy
  • Preliminary evaluation of the use of embryonic stem cells for the construction of tissue engineered vascular grafts (BLUE RIBBON)
    Presentation , 45th Annual Meeting , San Francisco, CA (01/01/2009)
    STS
  • The role of bone marrow mononuclear cell seeding for the development of a small diameter tissue engineered vascular graft
    Presentation , CA (12/01/2008)
    Tissue engineering and Regenerative Medicine society (TERMIS) North America
  • Preoperative Autologous Blood Donations for Children Weighing under 15kg in Pediatric Cardiac Surgery
    Presentation , 42nd Annual Meeting , Chicago, IL (01/01/2006)
    STS
  • New Tissue-Engineered Vascular Graft using Granulocyte Colony Stimulating Factor Without Cell Seeding
    Presentation , Scientific Sessions , Orland, FL (11/01/2003)
    AHA

Recent News Articles and Media Coverage

Printing the Heart

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