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Deborah Jean Andrew, M.S., Ph.D.
Professor of Cell Biology
Research Interests: Drosophila; Developmental genetics of organ formation
Dr. Deborah J. Andrew is a professor of cell biology at the Johns Hopkins University School of Medicine. Her research explores the regulation of form and function in epithelial tubes of fruit flies (Drosophila), providing insight into the mechanisms of epithelial tube morphogenesis and homeostasis in human development and disease.
Dr. Andrew received her B.S. and M.S. degrees in limnology and genetics, respectively, from the University of Central Florida. She earned her Ph.D. in molecular genetics at the University of California, San Diego, and completed her training with two postdoctoral research fellowships in developmental biology, the first at the University of Colorado and the second at Stanford University. She joined the Hopkins faculty in 1993 as an assistant professor, became an associate professor in 1999, and accepted the mantle of full professor in 2004.
She has authored or co-authored several dozen peer-reviewed publications and currently serves on the Editorial Board of the journal Developmental Dynamics. Her research has garnered numerous awards and grants, including two ongoing NIH grants on which she serves as principal investigator.
- Professor of Cell Biology
Departments / Divisions
- B.S., University of Central Florida (Florida) (1979)
- M.S., University of Central Florida (Florida) (1981)
- Ph.D., University of California (San Diego) (California) (1987)
Stanford University, Stanford, CA, 1993, Developmental Biology; University of Colorado, Boulder, CO, 1990, Developmental Biology
Research & Publications
Tube formation is a ubiquitous process required to sustain life in all multicellular organisms. Tubular organs include the lungs, vasculature, digestive and excretory systems, as well as secretory organs such as the pancreas, salivary, prostrate, and mammary glands. The Andrew lab studies the Drosophila trachea and salivary gland as model systems for tube formation to learn how organ size, shape and function is normally controlled. Over the past several years, the lab has identified many genes expressed in the trachea and salivary gland and are characterizing the subset required for early tube morphogenesis.
Two of the genes encode transcription factors required for internalization of either the trachea or salivary gland, trachealess and fork head. Three genes encode transcription factors controlling tube elongation, ribbon, huckebein and hairy. Finally, several genes encode components of signaling pathways required for organ positioning. Current efforts in the lab are directed toward identifying and characterizing the roles of the downstream effector molecules regulated by these transcription factors and signaling pathways. They also study the mechanisms whereby the salivary gland becomes specialized for secretion and have learned that secretory capacity in this and other secretory organs is largely controlled by a single transcription factor, CrebA.
Discovering mechanisms of epithelial tube formation
Debbie Andrew is a geneticist and developmental biologist. She explores the regulation of form and function in epithelial tubes of fruit flies (Drosophila). Using an array of genetic tools and genome-wide transcription profiling, Debbie’s lab has revealed key regulators of epithelial tube formation and physiological specialization, providing insight into the mechanisms of epithelial tube morphogenesis and homeostasis in human development and disease. Learn more about
Fox RM, Vaishnavi A, Maruyama R, and Andrew DJ (2013) "Organ-specific gene expression: the bHLH protein Sage provides tissue-specificity to Drosophila FoxA." Development. 140: 2160-71. PMID: 23578928
Ismat A, Cheshire A, Andrew DJ (2013) "The secreted AdamTS-A metalloprotease is required for collective cell migration." Development 140: 1981-1993. PMID: 23578928
Barbosa S, Fasanella G, Carreira S, Llarena M, Fox R, Barreca C, Andrew D, and O'Hare P. (2013) "An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcripton factor CREB-H." Traffic. 14: 382-398
Chung S-Y, Chavez C, Andrew DJ. (2011) "Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis." Developmental Biology 360: 160-172. PMID: 21963537
Fox RM, Hanlon CD, Andrew DJ. (2010) "The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity." Journal of Cell Biology 191: 479-492. PMID: 21041443
Kerman BE, Andrew DJ. (2010) "Staying alive: Dalmatian-mediated epigenetic blocking of apoptosis is essential for tissue maintenance." Developmental Dynamics 239:1609-21. PMID: 20503358
Andrew DJ, Ewald AJ. (2010) "Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration." Developmental Biology 341: 34-55. PMID: 19778532
Chung S-Y, Vining MS,, Bradley PL, Chan C-C, Wharton, KA, and Andrew DJ. (2009) "Serrano (Sano) functions with the planar cell polarity genes to control tracheal tube length." PLoS Genetics 5(11): e1000746. PMID: 19956736
Abrams EW, Mihoulides WK, and Andrew DJ. (2006) "Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4áSG1 and PH4áSG2." Development 133: 3517-3527. PMID: 16914497
Myat MM, Andrew DJ. (2002) "Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane." Cell 111:879-891. PMID: 12526813
Activities & Honors
- Professor’s Award for Distinction in Teaching the Basic Sciences, The Johns Hopkins University School of Medicine, 2000 - 2001
- Martin Kamen Award for Best Biochemistry Thesis, University of California, 1987 - 1988
- Cal Biochem Award for Molecular Research, 1983
- Co-organizer, Gordon Research Conference on Salivary Glands and Exocrine Biology, 2013
- Co-organizer, 51st Annual Drosophila Research Meeting, 2010
- Co-organizer, Santa Cruz Developmental Biology Meeting, 2006
- Editorial Board, Developmental Dynamics
- Faculty of 1000, Developmental Biology, 2004 - 2008
- Mid-Atlantic Representative, Drosophila Board of Directors, 1994 - 1997
- Organizational Committee, Biennial EMBO Workshop “Molecular and Developmental Biology of Drosophila”, Crete, Greece, 2010 - 2014
- Reviewer, NIDCR review of in house faculty, 2010 - 2011
- Special Emphasis Panel, NIAID International Centers of Excellence for Malaria Research, 2010
- Treasurer, Drosophila Board, 2013