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Amanda Marie Lauer, M.S., Ph.D.

Photo of Dr. Amanda Marie Lauer, M.S., Ph.D.

Assistant Professor of Otolaryngology - Head and Neck Surgery

Research Interests: Hearing loss; Efferent feedback to the cochlea; Auditory brainstem

Contact for Research Inquiries

Traylor Building
720 Rutland Ave
Baltimore, MD 21205 map
Phone: 443-287-6336

Background

Amanda Lauer, Ph.D., focuses her research on the perceptual and central nervous system consequences of hearing loss. The overall goal of her research program is to investigate how hearing loss changes synaptic organization of brain pathways and how those changes are reflected in behavior and auditory processing. Understanding the interplay between the effects of peripheral auditory damage and higher order function is of particular importance given our increasing exposure to noisy environments and the increased prevalence of hearing disorders in our aging population. Recent studies have focused on animal models of tinnitus, hyperacusis and temporal processing abnormalities.

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Titles

  • Assistant Professor of Otolaryngology - Head and Neck Surgery

Education

Degrees

  • B.S., St. Joseph's University (Pennsylvania) (1999)
  • M.S., St. Joseph's University (Pennsylvania) (2000)
  • Ph.D., University of Maryland (College Park) (Maryland) (2006)

Additional Training

Johns Hopkins University, Baltimore, Maryland, 2011, Otolaryngology

Research & Publications

Selected Publications

View all on Pubmed

Publications: Peer Reviewed Original Science Research

Lohr, B. L., Lauer, A. M., Newman, M. R., & Dooling, R. J. (2004). Hearing in the red-billed firefinch (Lagonosticta senegala) and the Spanish timbrado canary (Serinus canaria): The influence of natural and artificial selection on auditory abilities and vocal structure. Bioacoustics, 14, 83-98.

Lauer, A. M., Dooling, R. J., Leek, M. R., and Lentz, J. J. (2006). Phase effects in masking by harmonic complexes in three species of birds. Journal of the Acoustical Society of America, 119, 1251-1259.

Lauer, A. M., and Dooling, R. J. (2007). Evidence of hyperacusis in canaries with permanent hereditary high-frequency hearing loss. Seminars in Hearing, 28, 319-326.

Lauer, A. M., Dooling, R. J., Leek, M. R., and Poling, K. P. (2008). Detection and discrimination of simple and complex sounds by Belgian Waterslager canaries. Journal of the Acoustical Society of America, 122, 3615-3627.

Lauer, A. M., Dooling, R. J., and Leek, M. R. (2009). Psychophysical evidence for damage to the active processing mechanism in the Belgian Waterslager canary. Journal of Comparative Physiology A: Sensory, Neural, and Behavioral Physiology, 195, 193-202.

Lauer, A. M., May, B. J., Hao, Z. J., & Watson, J. (2009). Analysis of environmental sound levels in modern rodent housing rooms. Lab Animal, 38, 154-159.

Lauer, A. M., Molis, M., and Leek, M. R. (2009). Discrimination of time-reversed harmonic complexes by normal-hearing and hearing-impaired listeners. Journal of Association for Research in Otolaryngology, 10, 609-619.

May, B. J., Lauer, A.M., Roos, M. J. (2011). Impairments of the medial olivocochlear system (MOCS) increase the risk of noise-induced auditory neuropathy in laboratory mice. Otology and Neurotology, 32, 1568-1578.

Yang, Y., Aitoubah, J., Lauer A. M., Nuriya, M., Takamiya, K., Jia, Z., May, B. J., Huganir, R. L., and Wang, L. (2011). GluA4 is indispensable for driving ultra-fast neurotransmission across a high-fidelity central synapse. Journal of Physiology, 589, 4209-4227.

Lauer, A. M., May, B. J. (2011). The medial olivocochlear system attenuates the developmental impact of early noise exposure. Journal of the Association for Research in Otolaryngology, 12, 329-343.

Lauer, A. M., May, B. J. (2011). Acoustic basis of directional acuity in laboratory mice. Journal of the Association for Research in Otolaryngology, 12, 633-645.

Lauer, A. M., El-Sharkawy, A. M., Kraitchman, D. L., Edelstein, W. A. (2012). MRI acoustic noise can harm experimental and companion animals. Journal of Magnetic Resonance Imaging. 36, 743-747.

Lauer, A. M., Fuchs, P. A., Ryugo, D. K., Francis, H. W. (2012). Efferent synapses return to inner hair cells in the aging cochlea. Neurobiology of Aging, 33, 2892-2902.

Lina, I. A., Lauer, A. M. (2013). Rapid measurement of auditory filter shape in mice using the auditory brainstem response and notched noise. Hearing Research, 298, 73-79.

Schettino, A., Lauer, A. M. (2013). The efficiency of design-based stereology in estimating spiral ganglion populations in mice. Hearing Research, 304, 153-158.

Lauer, A. M., Connelly, C.J., Graham, H., Ryugo, D.K. (2013). Morphological characterization of bushy cells and their inputs in the laboratory mouse (Mus musculus) anteroventral cochlear nucleus. PLoS ONE 8(8): e73308. doi:10.1371/journal.pone.0073308.

Hiebler, S., Masuda, T., Moser, T., Liu, A., Faust, P., Chowdhury, N., Lauer, A., Bennett, J., Watkins, P., Zack, D., Braverman, N., Raymond, G., Steinberg, S. (2014). The Pex1-G844D mouse: A model for mild human Zellweger spectrum disorder. Mol Gen Metab 111:522-532.

McGuire, B. M., Fiorillo, B., Ryugo, D. K., Lauer, A. M. (2015). Auditory nerve synapses persist in ventral cochlear nucleus long after loss of acoustic input in mice with early-onset progressive hearing loss. Brain Res 1605:22-30.

Sun, D. Q., Lehar, M., Swarthout, L., Dai, C., Lauer, A. M., Carey, J.P., Mitchell D. E., Cullen, K. E., Della Santina, C. C. (2015). Histopathologic changes of the inner ear in Rhesus monkeys after intratympanic gentamycin injection and vestibular prosthesis electrode array implantation. J Assoc Res Otolaryngol. 16:373-87.

Ngodup, T., Goetz, J. A., McGuire, B. C., Sun, W., Lauer, A. M., Xu-Friedman, M. A. (in press). Activity-dependent, homeostatic regulation of neurotransmitter release from auditory nerve fibers. Proc Nat Acad Sci USA. doi: 10.1073/pnas.1420885112

Activities & Honors

Honors

  • Graduate Assistantship, Department of Psychology, St. Joseph's University, 1999 - 2000
  • Graduate Psychology Award, St. Joseph's University, 2000 - 2000
  • Graduate Fellowship, Department of Psychology, University of Maryland, 2000 - 2002
  • 2nd Place Award, Graduate Research Interaction Day, University of Maryland, 2001 - 2001
  • Student Travel Award, Meeting of the Association for Research in Otolaryngology, 2002 - 2002
  • Mentored Student Research Travel Award, American Auditory Society, 2002 - 2002
  • Ruth L. Kirschstein Individual Predoctoral National Research Service Award, NIDCD, 2002 - 2005
  • Ruth L. Kirschstein Institutional Postdoctoral National Research Service Award, NIDCD, 2007 - 2008
  • Ruth L. Kirschstein Individual l Postdoctoral National Research Service Award, NIDCD, 2008 - 2010
  • National Organization for Hearing Research Award, 2010 - 2010
  • American Hearing Research Foundation Research Award, 2011 - 2011

Memberships

  • Acoustical Society of America
  • Association for Research in Otolaryngology
  • Society for Neuroscience

Videos & Media

Recent News Articles and Media Coverage

How noise changes the way the brain gets information, Science 360 News (05/07/2015)

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