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School of Medicine
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Paul T. Strickland, Ph.D.
Joint Appointment in Oncology
Department of Environmental Health Sciences
Bloomberg School of Public Health
- Joint Appointment in Oncology
Centers & Institutes
Research & Publications
The research conducted in my laboratory focuses on molecular biomonitoring of genotoxic agents and genetic polymorphisms associated with their metabolism. The general theme is the assessment of carcinogen metabolites and genetic damage in human populations with known or suspected exposure to various occupational or environmental carcinogens. This approach has widespread application in assessing previous exposure to carcinogens and is increasingly being used as a predictor of ultimate disease risk. The ability to measure carcinogen metabolites and genetic damage in human tissues allows one to address a variety of public health issues related to exposure assessment and individual susceptibility to cancer. Furthermore, elucidating the spectrum of common polymorphisms in carcinogen-metabolizing and other genes associated with disease outcome provides an approach to assessing individual susceptibility to cancer.
Deziel NC, Wei WQ, Abnet CC, Qiao YL, Sunderland D, Ren JS, Schantz MM, Zhang Y, Strickland PT, Abubaker S, Dawsey SM, Friesen M, Roth MJ. A multi-day environmental study of polycyclic aromatic hydrocarbon exposure in a high-risk region for esophageal cancer in China. J Expo Sci Environ Epidemiol. 2012 Jul 18. doi: 10.1038/jes.2012.73. [Epub ahead of print] PubMed PMID: 22805987.
Jorgensen TJ, Ruczinski I, Yao Shugart Y, Wheless L, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer. Cancer Epidemiol. 2012; 36(5):e288-93. PubMed PMID: 22677152; PubMed Central PMCID: PMC3438291
Islami F, Boffetta P, van Schooten FJ, Strickland P, Phillips DH, Pourshams A, Fazel-Tabar Malekshah A, Godschalk R, Jafari E, Etemadi A, Abubaker S, Kamangar F, Straif K, Møller H, Schüz J, Malekzadeh R. Exposure to Polycyclic Aromatic Hydrocarbons Among Never Smokers in Golestan Province, Iran, an Area of High Incidence of Esophageal Cancer - a Cross-Sectional Study with Repeated Measurement of Urinary 1-OHPG in Two Seasons. Front Oncol. 2012;2:14. Epub 2012 Feb 17. PubMed PMID: 22655262; PubMed Central PMCID: PMC3356003.
Hofmann JN, Liao LM, Strickland PT, Shu XO, Yang G, Ji BT, Li HL, Rothman N, Kamangar F, Gao YT, Zheng W, Chow WH. Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study. BMC Cancer. 2013 Jun 11;13:282. doi: 10.1186/1471-2407-13-282. PubMed PMID: 23758680; PubMed Central PMCID: PMC3686696.
Alberg AJ, Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Smith MW, Strickland PT. DNA repair gene variants in relation to overall cancer risk: a population-based study. Carcinogenesis. 2013 Jan;34(1):86-92. PMID: 23027618; PMCID: PMC3534189.