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Cory Brayton, D.V.M.

Cory Flagg Brayton, D.V.M.

Photo of Dr. Cory Brayton, D.V.M.

Director, Phenotyping Core

Associate Professor of Molecular and Comparative Pathobiology

Expertise: Pathology and Laboratory Medicine

Research Interests: Phenotyping; Genetically Engineered Mice; Pathology; Cancer; Infectious Disease

Background

Cory Brayton, D.V.M., is an associate professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine. Her research focuses on phenotyping and pathology in diverse translational research areas, including cancer, aging, immunology, infectious diseases. Dr. Brayton serves as the director of the Phenotyping Core.

Dr. Brayton is a diplomate of the American College of Laboratory Animal Medicine (ACLAM), and of the American College of Veterinary Pathologists (ACVP). She served as president of ACVP in 2014.

Dr. Brayton’s expertise includes the spontaneous pathology and genetics of research mice, as well as the impacts of infectious and other environmental factors on pathology, disease expression, and other phenotypes in diverse research models.

She received her D.V.M. from Cornell University, and did postdoctoral research and pathology training in New York City at the Animal Medical Center, Cornell University Medical College, and The Rockefeller University. At The Rockefeller University (1989-1992), she became specifically interested in genetically engineered mice (GEM) models in translational research, and in their pathology and characterization (phenotyping).

At the Hospital for Special Surgery (1992-1998), she was attending veterinarian and Director of the Facility for Comparative Studies. At Baylor College of Medicine (1998-2004), she headed the Comparative Pathology Laboratory, and was responsible for health surveillance and diagnostic pathology for a diverse research population including more than 150,000 mice. She also served as attending veterinarian, and associate director of the Center for Comparative Medicine. In 2004, she moved to Johns Hopkins to develop the Phenotyping Core.

Dr. Brayton’s primary teaching interest is to improve and promote understanding of model organism biology and pathology, especially as it is relevant to translational research. She has developed, directed, co-directed, and lectured in symposia, conferences, courses and workshops relevant to phenotyping, pathology, genetics of mice and other laboratory animals, in the US and abroad. She has authored and coauthored books, chapters and invited reviews on mouse biology and pathology.

At JHU, she has developed symposia and courses including 680.712 Phenotyping for Functional Genetics (Mouse Pathobiology and Phenotyping Short Course), and participates as faculty and lecturer in 680.701 Principles of Animal Pathology and Genetically Engineered Mice; 680.702 LAM/PATH Integrated Problem Solving; 690.707 Experimental Design and Scientific Writing; 680.711 Comparative Pathology Conference; Toxicological Pathology, Bloomberg School of Public Health, and other courses.

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Titles

  • Director, Phenotyping Core
  • Associate Professor of Molecular and Comparative Pathobiology

Centers & Institutes

Research & Publications

Research Summary

Dr. Brayton’s primary research interest is in collaborating in experimental design, and as a pathologist in translational research.

Whether caused primarily by intended genetic manipulations, spontaneous mutations, experimental compounds, infections or other intended manipulations, phenotypes also are impacted by unintended and often under recognized nature and nurture influences. Dr. Brayton’s expertise includes the spontaneous pathology and genetics of research mice, as well as the impact of infectious and other environmental factors on pathology, disease expression and other phenotypes in diverse species.

She has published on comparative cardiovascular, pulmonary, renal, musculoskeletal, hematopoietic, neural and ophthalmic pathology, comparative carcinogenesis, autoimmune diseases and infectious diseases in mice and other species.

Contact her to discuss experimental design, phenotyping, collaboration or research pathology needs.

Lab

The  Phenotyping Core aims to facilitate interdisciplinary phenotyping and translational research collaborations, and offers preclinical research pathology support and collaboration.  As director of this collaborative core effort, Dr. Brayton reaches out to JHU faculty investigators who wish to participate in multidisciplinary initiatives, and additional participants in the core network are always welcome.  Since 2006 we have organized symposia and courses that emphasize JHU resources and faculty, including JHU Phenotyping Symposia in 2006, 2007, 2008, 2009, SOM graduate school course (ME 680.712) in 2007, 2008, and annual Mouse Pathobiology and Phenotyping Short Courses since 2010, and phenotyping and comparative pathology slide conferences.  She has become involved in national and international phenotyping initiatives, conferences and courses to promote understanding of mouse biology, pathology and phenotyping in contemporary preclinical translational research.

Core Facility: Phenotyping (and Pathology) Core (Phenocore)

Technology Expertise Keywords

Pathology; Phenotyping; mice; cancer; ageing; infectious disease

Selected Publications

View all on Pubmed

  1. Brayton CF, Treuting PM, and Ward JM. "Pathobiology of Aging Mice and GEM: Background Strains and Experimental Design." Veterinary pathology, 2012. 49(1): p. 85-105. Invited Review.
  2. Treuting PM, Clifford CB, Sellers RS, and Brayton CF. "Of mice and microflora: considerations for genetically engineered mice." Veterinary pathology, 2012. 49(1): p. 44-63. Invited Review.
  3. Sellers RS, Clifford CB, Treuting PM, and Brayton C. "Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice." Veterinary pathology, 2012. 49(1): p. 32-43. Invited Review.
  4. Harris JE Jr., Shin J, Lee B, Pelosky K, Hooker CM, Harbom K, Hulbert A, Zahnow C, Yang SC, Baylin S, Brayton C, and Brock MV. "A Murine Xenograft Model of Spontaneous Metastases of Human Lung Adenocarcinoma." J Surg Res, 2011.
  5. Bolon B, Altrock B, Barthold SW, Baumgarth N, Besselsen D, Boivin G, Boyd KL, Brayton C, Cardiff RD, Couto S, Eaton KA, Foreman O, Griffey SM, Perle KL, Lairmore MD, Liu C, Meyerholz DK, Nikitin AY, Schoeb TR, Schwahn D, Sellers RS, Sundberg JP, Tolwani R, Valli VE, and Zink MC "Advancing Translational Research." Science, 2011. 331(6024): p. 1516-1517.

Academic Affiliations & Courses

Graduate Program Affiliation

Graduate Program Comparative Pathology in Translational Science

Courses and Syllabi

  • Phenotyping for Functional Genetics (Mouse Pathobiology and Phenotyping Short Course) (680.712)
  • Comparative Pathology Tuesday PM slide conference

Activities & Honors

Memberships

  • American Association for Laboratory Animal Science (A.A.L.A.S.), 1990
    member
  • American College of Laboratory Animal Medicine (A.C.L.A.M.), 1997
    Diplomate
  • American College of Veterinary Pathologists (A.C.V.P.), 2009 - 2012
    Councilor (elected)
  • American College of Veterinary Pathologists (A.C.V.P.), 1997
    Diplomate
  • American College of Veterinary Pathologists (A.C.V.P.), 2014
    President
  • American College of Veterinary Pathologists (A.C.V.P.), 2013
    President Elect
  • American Veterinary Medical Association, 1985
    member
  • Charles Louis Davis Foundation for the Advancement of Veterinary and Comparative Pathology
  • Institute for Laboratory Animal Research ILAR (National Academy of Sciences Division on Earth and Life Studies of the National Research Council), 2012
    Co Editor in Chief, ILAR Journal
  • Institute for Laboratory Animal Research ILAR (National Academy of Sciences Division on Earth and Life Studies of the National Research Council), 2012 - 2016
    Councilor
  • International Council for Laboratory Animal Science (ICLAS), 2014
    US representative
  • International Mammalian Genome Society (IMGS), 2013
    Editorial Board, Mammalian Genome
  • Society of Toxicologic Pathology, 2006
    member

Professional Activities

  • Chair, Johns Hopkins Department of Molecular and Comparative Pathobiology
    Phenotyping Core Committee
  • Diplomate, American College of Laboratory Animal Medicine, 1997
  • Diplomate, American College of Veterinary Pathologists, 1997
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