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Luis Andres Garza, M.D., Ph.D.

Photo of Dr. Luis Andres Garza, M.D., Ph.D.

Associate Professor of Dermatology

Male

Languages: English, Spanish

Expertise: Dermatology, Wound Healing

Research Interests: Skin Regeneration; Skin Stem Cells; and Wound Healing

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410-464-6641
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Locations

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-955-5933

4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-5933
Fax: 410-550-8177

Contact for Research Inquiries

Johns Hopkins School of Medicine
1550 Orleans Street
Suite 204 Koch CRBII
Baltimore, MD 21231 map
Phone: 410-955-8662 x 58662
Fax: 410-614-0635

Background

Dr. Luis Andres Garza is an associate professor of dermatology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include wound care and general dermatology.

Dr. Garza received his undergraduate degree in neurobiology from Cornell University. He earned his M.D. and Ph.D. together from the medical scientist training program at the University of Pennsylvania School of Medicine. Dr. Garza completed his residency in dermatology at the University of Michigan and performed his fellowship in dermatology at the University of Pennsylvania. He joined the Johns Hopkins faculty in 2009.

In addition to treating patients, Dr. Garza runs a molecular biology laboratory that studies skin stem cells and wound healing with an emphasis on identifying the next generation of wound therapeutics and diagnostics.

Dr. Garza is an associate editor for the Journal of Investigative Dermatology. He is a member of the American Academy of Dermatology, the Society for Investigative Dermatology and the North American Clinical Dermatology Society.

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Titles

  • Associate Professor of Dermatology
  • Assistant Professor of Oncology

Education

Degrees

  • MD PhD, University of Pennsylvania School of Medicine (2001)

Residencies

  • University of Michigan Health System / Dermatology (2005)

Board Certifications

  • American Board of Dermatology / Dermatology (2005, 2013)

Research & Publications

Research Summary

Dr. Garza runs a molecular biology laboratory that studies skin stem cells and wound healing with an emphasis on identifying the next generation of wound therapeutics and diagnostics.

While at the University of Pennsylvania, Dr. Garza and Dr. George Cotsarelis discovered that prostaglandins might be the catalyst that causes baldness. They also pinpointed the receptor on the prostaglandin cell, making it a target for possible future therapies for male pattern baldness.

Lab

Our group is interested in investigating hypotheses on basic skin questions that are directly relevant to skin disease in humans. We hope that through rigorous hypothesis-driven research into skin biology, we will gain important insights that will directly improve patient care.

Our model system is the skin. To answer basic questions regarding stem cell biology and regeneration, we choose the skin because of its accessibility, the depth of current knowledge, and the complexity of epithelial/mesenchymal interactions in the context of relevant vasculature, nerves and hematopoietic cells.

The current focus of the lab is what controls and maintains skin identity. Regions of our skin are remarkably diverse in function and features. Despite constant cellular turnover, each area’s features are remarkably maintained. We study how, under normal conditions, identity is actively maintained and how it might be manipulated. We also study how, during wounding, skin identity is typically lost (i.e., scar), but in rare situations complete regeneration occurs.

Understanding these questions will have broad significance to regeneration and stem cell biology in multiple organs. Understanding wound healing programs that re-initiate embryonic developmental patterns might eventually lead to insights on how to trigger the re-growth of a severed human limb, for example.

Lab Website: Garza Laboratory

Clinical Trials

"Effects of Antibiotics and Acne on the Skin Microbiome"

"Feasibility Study for Fibroblast Autologous Skin Grafts"

"Timolol for the Treatment of Acne and Rosacea"

 

Selected Publications

Nelson AM, Loy DE, Lawson JA, Katseff AS, Fitzgerald GA, Garza LA. "Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44." J Invest Dermatol. 2013 Apr;133(4):881-9. doi: 10.1038/jid.2012.398. Epub 2012 Nov 29

Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Blatt HB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, FitzGerald GA, Cotsarelis G. "Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia." Sci Transl Med. 2012 Mar 21;4(126):126ra34. doi: 10.1126/scitranslmed.3003122

Nelson AM, Reddy Sk, Ratliff TS, Hossain MZ, Katseff AS, Zhu AS, Chang E, Resnik SR, Page C, Kim D, Whiitam AJ, Miller SC, Garza LA. "dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration". Cell Stem Cell. 2015 Aug 6; 17(2):139-51

Kim D, Hossain MZ, Nieves A, Gu L, Ratliff TS, Mi Oh S, Park A, Han S, Yang NB, Qi J, Taube JM, Kang S, Garza LA. "To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and is Activated Ectopically in Skin Disease". Am J Pathol. 2016 May; 186(5): 1140-50

Nelson AM, Katseff AS, Resnik SR, Ratliff TS, Zhu AS, Garza LA. "Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis". J Invest Dermatol. 2016 May; 136(5): 1051-3

Activities & Honors

Honors

  • Winter Eicosanoid conference NIEHS/NIH Travel Award for Young Investigators, 2011
  • Johnson-Beerman Basic Science Research Award, College of Physicians of Philadelphia, 2007
  • TAMS University of Michigan Medical Student Appreciation Award for Mentoring, 2005
  • University of Michigan Department of Dermatology Upjohn Resident Research Award, 2005
  • Michigan Dermatological Society Ralph Coskey Resident Research Award, 2005
  • North American Clinical Dermatologic Society Resident Clinical Research Award, 2005
  • National Young Investigator Award, Clinical Research AAD, 2005
  • Albert Kligman SID Travel Award, 2004

Memberships

  • American Academy of Dermatology
  • North American Clinical Dermatology Society
  • Society for Investigative Dermatology

Videos & Media

Recent News Articles and Media Coverage

#TomorrowsDiscoveries: Healing by Regeneration, Johns Hopkins Medicine (May 20, 2016)

Scientists Grow New Hair In A Lab, But Don't Rush To Buy A Comb, NPR, October 21, 2013

What to Do If You're Going Bald, Men’s Health, May 15, 2013

A War on Baldness, Fought in the Follicle, The New York Times, July 28, 2012

Big Science Zooms in on a New Cure for Baldness, Los Angeles Times, March 21, 2012

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