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Phuoc T. Tran, M.D., Ph.D.

Phuoc Tho Tran, M.D., Ph.D.
Clinical Director of Radiation Oncology and Molecular Radiation Sciences
Associate Professor of Radiation Oncology and Molecular Radiation Sciences

Male

Appointment Phone

410-502-8000

Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Clinical Director of Radiation Oncology and Molecular Radiation Sciences
  • Associate Professor of Radiation Oncology and Molecular Radiation Sciences
  • Associate Professor of Oncology
  • Associate Professor of Urology

Centers & Institutes

Departments

  • Oncology
  • Radiation Oncology and Molecular Radiation Sciences
  • Urology

Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-502-8000

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-614-6477
Fax: 410-502-2821

The Johns Hopkins Hospital

Appointment Phone: 410-502-8000

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

The Johns Hopkins Hospital

600 N. Wolfe Street
Halstead
Baltimore, MD 21287 map

Expertise

Adrenal Cancer, Bladder Cancer, Image-Guided Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Metastatic Bone Disease, Metastatic Disease, Oligometastatic Disease, Penile Cancer, Prostate Cancer, Radiation Oncology, Stereotactic Body Radiation Therapy, Testicular Cancer, Urethral Cancer

Research Interests

Radiosensitizers; Genetically engineered mouse models of disease; Epithelial Plasticity (Epithelial-Mesenchymal Transition and Mesenchymal-Epithelial Transition)

Biography

Dr. Phuoc T. Tran is an associate professor of radiation oncology and molecular radiation sciences, oncology and urology at the Johns Hopkins School of Medicine.

Dr. Tran is the Clinical Director of Radiation Oncology at the Sidney Kimmel Comprehensive Cancer Center and treats patients with cancers of the genitourinary system and uses stereotactic radiation techniques (such as SRS and SBRT/SABR) for the treatment of patients with oligometastatic disease. His research focuses on the improvement of clinical radiotherapy for the treatment of adrenal, bladder, penile, prostate, testicular and urethral cancer as well as patients with oligometastatic disease.

Dr. Tran completed his medical and gradaute training at the Oregon Health & Sciences University in Portland. He conducted a residency in radiation oncology at the Stanford University School of Medicine in 2008 where he was an instructor of radiation oncology before then joining the staff of Johns Hopkins.

Dr. Tran has published more than 60 scholarly works, has received numerous awards for his research, and is a primary investigator on a number of clinical trials.  He is a member and holds leadership positions in the Radiological Society of North America (RSNA) and the American Society for Radiology Oncology (ASTRO), and is board certified in radiation oncology by the American Board of Radiology.

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    Additional Information

  • Education +

    Degrees

    • Oregon Health & Sciences University / MD PhD (2003)

    Residencies

    • Stanford University School of Medicine / Radiation Oncology (2008)

    Certifications

    • American Board of Radiology / Radiation Oncology (2009)
  • Research & Publications +

    Research Summary

    Dr. Tran’s research focuses on the improvement of clinical radiotherapy for the treatment of adrenal, bladder, penile, prostate, testicular and urethral cancer. To learn how tumors grow and why some cancers are resistant to treatment, he studies the transitions of epithelial and mesenchymal cellular states in transgenic mouse models.

    Additionally, Dr. Tran is working with colleagues from top-ranked institutions nationwide to establish a National Radiation Oncology Registry. The purpose of the registry is to improve the care of cancer patients by capturing and studying information about cancer treatments and outcomes.

    Lab:

    Dr. Tran and his laboratory focus their studies on the transitions between epithelial and mesenchymal cellular states and the implications of these transitions for tumorigenesis, cancer treatment resistance and radiation-induced fibrosis. Their research utilizes a variety of inducible transgenic mouse models and non-invasive rodent imaging.

    One of these transitions, known as epithelial-mesenchymal transition (EMT), is a conserved developmental program that when inappropriately activated in post-natal life has been associated with organ fibrosis, tumorigenesis and metastasis. A major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation induced late effects. Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.

    The Tran lab is committed to translating discoveries from the laboratory bench into novel cancer prevention, diagnostic and treatment approaches that can be tested in the clinic.

    Clinical Trials:

    Radiation and Androgen Ablation for Prostate Cancer

    MRI for Assessing Prostate Cancer Response

    Stereotactic Body Radiation with Nelfinavir for Oligometastases


    Clinical Trial Keywords: Prostate cancer, Radiation therapy

    Selected Publications View all on PubMed

    1. Tran PT*,+, Shroff EH*, Burns TF*, Thiyagarajan S, Das ST, Zabuawala T, Chen J, Cho YJ, Luong R, Tamayo P, Salih T, Aziz K, Adam SJ, Vicent S, Nielsen CH, Withofs N, Sweet-Cordero A, Gambhir SS, Rudin CM, Felsher DW+. "Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis." PLoS Genet. 2012;8(5):e1002650. doi: 10.1371/journal.pgen.1002650. Epub 2012 May 24. * - these authors contributed equally; and + - corresponding authors.
    2. Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah S. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, and Charles M. Rudin. Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer. Mol Cancer Res 11 (2013) 329-338.
    3. Tran PT, Bendapudi PK, Lin HJ, Choi P, Koh S, Chen J, Horng G, Hughes NP, Schwartz LH, Miller VA, Kawashima T, Kitamura T, Paik D, Felsher DW. "Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation." Sci Transl Med. 2011 Oct 5;3(103):103ra99. doi: 10.1126/scitranslmed.3002018.
    4. Jason A. Efstathiou, Deborah S. Nassif, Todd R. McNutt, C. Bob Bogardus, Walter Bosch, Jeff Carlin, Ron C. Chen, Henry Chou, Dave Eggert, Benedick Fraass, Joel Goldwein, Karen E. Hoffman, Ken Hotz, Margie Hunt, Marc Kessler, Colleen A. F. Lawton, Chuck Mayo, Jeff M. Michalski, Sasa Mutic, Louis Potters, Chris M. Rose, Howard M. Sandler, Greg Sharp, Wolfgang Tomé, Phuoc T. Tran, Terry Wall, Anthony L. Zietman, Peter E. Gabriel, Justin E. Bekelman. Practice-Based Evidence to Evidence-Based Practice: Building the National Radiation Oncology Registry. J Oncol Pract 9 (2013) e90-95.
    5. Aaron T. Wild*, Nishant Gandhi*,Sivarajan T. Chettiar, Khaled Aziz, Rajendra P. Gajula, Russell D. Williams, Rachit Kumar, Kekoa Taparra, Jing Zeng, Jessica A, Cades, Esteban Velarde, Siddharth Menon, Jean-Francois Geschwind, David Cosgrove, Timothy M. Pawlik, Anirban Maitra, John Wong, Russell K. Hales, Michael Torbenson, Joseph M. Herman+, Phuoc T. Tran+. Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinoma. PLoS ONE 8 (2013) e65726.
    6. Rajendra P. Gajula*, Sivarajan T. Chettiar*, Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Kato, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana Fertig, Shyam Biswal, Timothy F. Burns, Christine Chung, Charles M. Rudin, Joseph M. Herman, Russell K. Hales, Venu Raman, Steven An, Phuoc T. Tran. The twist box domain is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res 11 (2013) 1387-1400**. PMID: 23982216. PMCID: PMC3833995. * - these authors contributed equally. ** - Cover illustration and Highlighted in Mol Cancer Res.
    7. Zhou H, Rodriguez M, van den Haak F, Nelson G, Jogani R, Xu J, Zhu X, Xian Y, Tran PT, Felsher DW, Keall PJ, Graves EE. "Development of a MicroCT-Based Image-Guided Conformal Radiotherapy System for Small Animals." Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):297-305. doi: 10.1016/j.ijrobp.2009.11.008. Epub 2010 Apr 13.
    8. Nielsen CH, Kimura RH, Withofs N, Tran PT, Miao Z, Cochran JR, Cheng Z, Felsher D, Kjær A, Willmann JK, Gambhir SS. "PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide." Cancer Res. 2010 Nov 15;70(22):9022-30. doi: 10.1158/0008-5472.CAN-10-1338. Epub 2010 Nov 9.
  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Graduate Program in Cellular and Molecular Medicine
  • Activities & Honors +

    Honors

    • John Muir College Caledonian Honor Society, University of California, 1995
    • Regents Scholar, University of California, 1995 - 1996
    • Graduated magna cum laude, University of California, 1996
    • Laurel Merit MD/PhD Scholar, OHSU, 1996 - 2003
    • Molecular Hematology Research Training Fellow, OHSU, 1998 - 2001
    • Deans Medical Student Research Award, OHSU, 2003
    • Research Resident, Radiological Society of North America , 2006
    • Roentgen Resident Research Award, Radiological Society of North America , 2006
    • Fellow, Henry S. Kaplan Research, 2007
    • Malcolm A. Bagshaw Award, 2007
    • Methods in Clinical Cancer Research Workshop Scholarship, ASCO/AACR , 2007
    • Fellow, Parker B. Francis, 2008 - 2011
    • Fellow, Radiological Society of North America Research, 2008
    • Junior Faculty Career Research Training Award, ASTRO, 2009 - 2011
    • Prostate Cancer Physician Research Training Award, DoD , 2011 - 2016
    • The Phyllis and Brian L. Harvey Scholar - Patrick C. Walsh Prostate Cancer Research Fund Award, 2011 - 2013
    • Educator of The Year, Association of Residents in Radiation Oncology (ARRO) , 2012
    • Included among Top Doctors, Baltimore Magazine, 2012
    • Research Scholar, American Cancer Society , 2012 - 2016
    • Uniting Against Lung Cancer Award, 2012 - 2014
    • 1R01CA166348-01A1, National Cancer Institute , 2013 - 2018
    • Alpha Omega Alpha Honor Medical Society Alumni Award, Oregon Health & Sciences University Chapter, 2013
    • Early Career Achievement Award, Oregon Health & Sciences University School of Medicine Alumni Association , 2013
    • Patrick C. Walsh Prostate Cancer Research Fund Award, 2013 - 2014
    • Sidney Kimmel Translational Scholar Award, 2013 - 2015

    Memberships

    • American College of Radiology, 2004
    • American Society for Radiation Oncology, 2004
    • Radiological Society of North America , 2004
    • American College of Radiation Oncology , 2005
    • American Association for Cancer Research , 2007
    • American Society of Clinical Oncology , 2007
    • American Thoracic Society, 2008 - 2012
    • Radiation Research Society , 2011
    • The EMT International Association , 2011
    • Alpha Omega Alpha Honor Medical Society , 2013
  • Videos & Media +
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