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Phuoc T. Tran, M.D., Ph.D.

Phuoc Tho Tran, M.D., Ph.D.

Photo of Dr. Phuoc T. Tran, M.D., Ph.D.

Clinical Director of Radiation Oncology and Molecular Radiation Sciences

Associate Professor of Radiation Oncology and Molecular Radiation Sciences

Male

Expertise: Adrenal Cancer, Bladder Cancer, Image-Guided Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Metastatic Bone Disease, Metastatic Disease, Oligometastatic Disease, Penile Cancer, Prostate Cancer, Radiation Oncology, Stereotactic Body Radiation Therapy, Testicular Cancer, Urethral Cancer ...read more

Research Interests: Radiosensitizers; Genetically engineered mouse models of disease; Epithelial Plasticity (Epithelial-Mesenchymal Transition and Mesenchymal-Epithelial Transition)

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Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-502-8000

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-614-6477
Fax: 410-502-2821

The Johns Hopkins Hospital
Appointment Phone: 410-502-8000

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Background

Dr. Phuoc T. Tran is an associate professor of radiation oncology and molecular radiation sciences, oncology and urology at the Johns Hopkins School of Medicine.

Dr. Tran is the Clinical Director of Radiation Oncology at the Sidney Kimmel Comprehensive Cancer Center and treats patients with cancers of the genitourinary system and uses stereotactic radiation techniques (such as SRS and SBRT/SABR) for the treatment of patients with oligometastatic disease. His research focuses on the improvement of clinical radiotherapy for the treatment of primarily prostate cancer, but also adrenal, bladder, urethral, testicular and penile cancer as well as patients with oligometastatic disease.

Dr. Tran completed his medical and graduate training at the Oregon Health & Sciences University in Portland. He conducted a residency in radiation oncology at the Stanford University School of Medicine in 2008 where he was an instructor of radiation oncology before then joining the staff of Johns Hopkins.

Dr. Tran has published more than 70 scholarly works, has received numerous awards for his research, and is a primary investigator on a number of clinical trials.  He is a member and holds leadership positions in the Radiological Society of North America (RSNA) and the American Society for Radiology Oncology (ASTRO), and is board certified in radiation oncology by the American Board of Radiology.

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Titles

  • Clinical Director of Radiation Oncology and Molecular Radiation Sciences
  • Associate Professor of Radiation Oncology and Molecular Radiation Sciences
  • Associate Professor of Oncology
  • Associate Professor of Urology

Education

Degrees

  • MD PhD, Oregon Health & Sciences University (2003)

Residencies

  • Stanford University School of Medicine / Radiation Oncology (2008)

Board Certifications

  • American Board of Radiology / Radiation Oncology (2009)

Research & Publications

Research Summary

Dr. Tran’s research focuses on the improvement of clinical radiotherapy for the treatment of primarily prostate, as well as adrenal, bladder, penile, testicular and urethral cancer. To learn how tumors arise, how they spread and why some cancers are resistant to treatment, he studies tumor cell epithelial plasticity - transitions of epithelial and mesenchymal cellular states.

Lab

Dr. Tran and his laboratory focus their studies on tumor cell epithelial plasticity - the transitions between epithelial and mesenchymal cellular states and the implications of these transitions for tumorigenesis, cancer treatment resistance and radiation-induced fibrosis. Their research utilizes a variety of inducible transgenic mouse models, non-invasive rodent imaging as well as more tradiational molecular, biochemical and cell biologic approaches.  One of these transitions, known as epithelial-mesenchymal transition (EMT), is a conserved developmental program that when inappropriately activated in post-natal life has been associated with organ fibrosis, tumorigenesis and metastasis.

A major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation induced late effects.

Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.

The Tran lab is committed to translating discoveries from the laboratory bench into novel cancer prevention, diagnostic and treatment approaches that can be tested in the clinic.

Lab Website: The Tran Lab

Technology Expertise Keywords

epithelial plasticity; epithelial-mesenchymal transition (EMT); genetically engineered mouse models (GEMMs)

Clinical Trial Keywords

Prostate cancer, Radiation therapy, Oligometastasis, SBRT/SABR

Clinical Trials

Radiation and Androgen Ablation for Prostate Cancer

MRI for Assessing Prostate Cancer Response

Stereotactic Body Radiation with Nelfinavir for Oligometastases

Selected Publications

View all on Pubmed

Tran PT*,+, Shroff EH*, Burns TF*, Thiyagarajan S, Das ST, Zabuawala T, Chen J, Cho YJ, Luong R, Tamayo P, Salih T, Aziz K, Adam SJ, Vicent S, Nielsen CH, Withofs N, Sweet-Cordero A, Gambhir SS, Rudin CM, Felsher DW+. "Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis." PLoS Genet. 2012;8(5):e1002650. doi: 10.1371/journal.pgen.1002650. Epub 2012 May 24. * - these authors contributed equally; and + - corresponding authors.

Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah S. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, and Charles M. Rudin. Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer. Mol Cancer Res 11 (2013) 329-338.

Tran PT, Bendapudi PK, Lin HJ, Choi P, Koh S, Chen J, Horng G, Hughes NP, Schwartz LH, Miller VA, Kawashima T, Kitamura T, Paik D, Felsher DW. "Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation." Sci Transl Med. 2011 Oct 5;3(103):103ra99. doi: 10.1126/scitranslmed.3002018.

Jason A. Efstathiou, Deborah S. Nassif, Todd R. McNutt, C. Bob Bogardus, Walter Bosch, Jeff Carlin, Ron C. Chen, Henry Chou, Dave Eggert, Benedick Fraass, Joel Goldwein, Karen E. Hoffman, Ken Hotz, Margie Hunt, Marc Kessler, Colleen A. F. Lawton, Chuck Mayo, Jeff M. Michalski, Sasa Mutic, Louis Potters, Chris M. Rose, Howard M. Sandler, Greg Sharp, Wolfgang Tomé, Phuoc T. Tran, Terry Wall, Anthony L. Zietman, Peter E. Gabriel, Justin E. Bekelman. Practice-Based Evidence to Evidence-Based Practice: Building the National Radiation Oncology Registry. J Oncol Pract 9 (2013) e90-95.

Aaron T. Wild*, Nishant Gandhi*,Sivarajan T. Chettiar, Khaled Aziz, Rajendra P. Gajula, Russell D. Williams, Rachit Kumar, Kekoa Taparra, Jing Zeng, Jessica A, Cades, Esteban Velarde, Siddharth Menon, Jean-Francois Geschwind, David Cosgrove, Timothy M. Pawlik, Anirban Maitra, John Wong, Russell K. Hales, Michael Torbenson, Joseph M. Herman+, Phuoc T. Tran+. Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinoma. PLoS ONE 8 (2013) e65726.

Rajendra P. Gajula*, Sivarajan T. Chettiar*, Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Kato, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana Fertig, Shyam Biswal, Timothy F. Burns, Christine Chung, Charles M. Rudin, Joseph M. Herman, Russell K. Hales, Venu Raman, Steven An, Phuoc T. Tran. The twist box domain is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res 11 (2013) 1387-1400**. PMID: 23982216. PMCID: PMC3833995. * - these authors contributed equally. ** - Cover illustration and Highlighted in Mol Cancer Res.

Academic Affiliations & Courses

Graduate Program Affiliation

Graduate Program in Cellular and Molecular Medicine

Activities & Honors

Honors

  • Fellow, Henry S. Kaplan Research, 2007
  • Alpha Omega Alpha Honor Medical Society Alumni Award, Oregon Health & Sciences University Chapter, 2013
  • Fellow, Parker B. Francis, 2008 - 2011
  • Fellow, Radiological Society of North America Research, 2008
  • John Muir College Caledonian Honor Society, University of California, 1995
  • 1R01CA166348-01A1, National Cancer Institute , 2013 - 2018
  • Sidney Kimmel Translational Scholar Award, 2013 - 2015
  • Patrick C. Walsh Prostate Cancer Research Fund Award, 2013 - 2014
  • Early Career Achievement Award, Oregon Health & Sciences University School of Medicine Alumni Association , 2013
  • Research Scholar, American Cancer Society , 2012 - 2016
  • Uniting Against Lung Cancer Award, 2012 - 2014
  • Included among Top Doctors, Baltimore Magazine, 2012
  • Educator of The Year, Association of Residents in Radiation Oncology (ARRO) , 2012
  • Prostate Cancer Physician Research Training Award, DoD , 2011 - 2016
  • The Phyllis and Brian L. Harvey Scholar - Patrick C. Walsh Prostate Cancer Research Fund Award, 2011 - 2013
  • Junior Faculty Career Research Training Award, ASTRO, 2009 - 2011
  • Malcolm A. Bagshaw Award, 2007
  • Methods in Clinical Cancer Research Workshop Scholarship, ASCO/AACR , 2007
  • Research Resident, Radiological Society of North America , 2006
  • Roentgen Resident Research Award, Radiological Society of North America , 2006
  • Deans Medical Student Research Award, OHSU, 2003
  • Molecular Hematology Research Training Fellow, OHSU, 1998 - 2001
  • Laurel Merit MD/PhD Scholar, OHSU, 1996 - 2003
  • Graduated magna cum laude, University of California, 1996
  • Regents Scholar, University of California, 1995 - 1996
  • Johns Hopkins Catalyst Award, 2015
  • ASCO Leadership Development Program, 2015
  • Movember Foundation-PCF Challenge Award, 2015

Memberships

  • Alpha Omega Alpha Honor Medical Society , 2013
  • American Association for Cancer Research , 2007
  • American College of Radiation Oncology , 2005
  • American College of Radiology, 2004
  • American Society for Radiation Oncology, 2004
  • American Society of Clinical Oncology , 2007
  • American Thoracic Society, 2008 - 2012
  • Radiation Research Society , 2011
  • Radiological Society of North America , 2004
  • The EMT International Association , 2011
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