Dr. Tamara Lotan is a urologic pathologist who studies how oncogenic signaling pathways regulate epithelial morphogenesis during embryonic development and tumorigenesis. Using novel transgenic mouse models combined with 3-D culture and state-of-the-art time-lapse imaging techniques, Dr. Lotan is defining the roles of these critical signals in prostate and mammary epithelial migration and polarity.
Dr. Lotan’s research laboratory focuses on the role of PTEN/PI3K/mTOR signaling in epithelial development and tumorigenesis. Her basic science lab works with a number of epithelial systems (prostate, breast and skin) and is principally interested in understanding how these oncogenic signaling pathways regulate epithelial differentiation, apico-basal polarity, and cell migration. Using transgenic mouse models combined with 3-D culture and state-of-the-art live cell imaging techniques, the hope is that by understanding the role of this signal transduction network in epithelial embryonic development, they can help to elucidate the significance of these oncogenic signals during tumorigenesis and tumor progression.
The translational side of Dr. Lotan’s laboratory effort is focused on validating PTEN as a potential predictive and prognostic biomarker in prostate cancer and on defining alternative mechanisms of PTEN inactivation in prostate cancer. There is also ongoing interest in the molecular phenotype of rare subtypes of prostate cancer, including small cell carcinoma, p63-positive prostatic carcinoma and intraductal prostatic carcinoma.
- Lotan TL, Lyon M, Huo D, Taxy JB, Brendler C, Foster B, Stadler W, Rinker-Schaeffer CW. Upregulation of MKK4, MKK6 and MKK7 during Prostate Cancer Progression: An Important Role for SAPK Signaling in Prostatic Neoplasia. Journal of Pathology 2007; 212(4):386-394.
- Lotan TL, Tefs K, Schuster V, Miller JL, Manaligod J, Filstead A, Yamada D, Krausz T. Inherited Plasminogen Deficiency Presenting as Ligneous Vaginitis: A Case Report with Molecular Correlation and Review of the Literature. Human Pathology 2007; 38(10):1569-1575.
- Lotan TL, Hickson J, Souris J, Huo D, Taylor J, Li T, Otto K, Yamada SD, Macleod K, Rinker-Schaeffer CW. Taylor J, Otto K. Suppression of Ovarian Cancer Metastatic Colonization by JNKK1/MKK4 is Associated with Cellular Growth Arrest and Upregulation of p21. Cancer Research 2008; 68(7):2166-75.
- Lotan TL and Epstein JI. Diffuse Adenosis of the Prostate Peripheral Zone in Needle Biopsy and Prostatectomy Specimens. American Journal of Surgical Pathology 2008; 32(9):1360-6.
- Lotan TL and Epstein JI. Gleason Grading of Prostatic Adenocarcinoma with Glomeruloid Features on Needle Biopsy. Human Pathology 2008, in press.
- Lotan TL, Ye H, Melamed J, Wu XR, Shih IeM and Epstein JI. "An Immunohistochemical Panel to Identify the Primary Site of Invasive Micropapillary Carcinoma." Am J Surg Pathol. 2009 Jul;33(7):1037-41. doi: 10.1097/PAS.0b013e3181962dcd.
- Lotan TL, Toubaji A, Albadine R, Latour M, Herawi M, Meeker M, Epstein JI and Netto GJ. "TMPRSS2-ERG Gene Fusions are Infrequent in Prostatic Ductal Adenocarcinomas." Modern Pathology. (2009) 22, 359–365; doi:10.1038/modpathol.2008.236. Epub 16 January 2009.
- Lotan TL, Wang W,Gupta NS, Toubaji A, Haffner MC, Meeker AK, De Marzo AM, Epstein JI, and Netto GJ. "ERG Gene Rearrangements are Common in Prostatic Small Cell Carcinoma." Modern Pathology. 2011; 24(6):820-8. doi: 10.1038/modpathol.2011.7. Epub 2011 Feb 18.
- Lotan TL, Gurel B, Sutcliffe S, Esopi D, Liu W, Xu J, Hicks JL, Park BH, Humphreys E, Partin AW, Han M, Netto GJ, Isaacs WB, De Marzo AM. "PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients." Clinical Cancer Research. 2011; 17(20):6563-73. doi: 10.1158/1078-0432.CCR-11-1244. Epub 2011 Aug 30.
- Ghosh S, Lau H, Simons BW, Powell JD, Meyers DJ, De Marzo AM, Berman DM, Lotan TL. "PI3K/mTOR Signaling Regulates Prostatic Branching Morphogenesis." Developmental Biology. 2011; 360(2):329-42. doi: 10.1016/j.ydbio.2011.09.027. Epub 2011 Oct 8.