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Jay Jan Pillai, M.D.

Director, Functional MR Imaging
Associate Professor of Radiology and Radiological Science


Appointment Phone


Main Location

The Johns Hopkins Hospital - Main Entrance

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Functional MR Imaging
  • Associate Professor of Radiology and Radiological Science



The Johns Hopkins Hospital - Main Entrance

1800 Orleans Street
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-0100

4940 Eastern Avenue
Baltimore, MD 21224 map

Johns Hopkins Outpatient Center

601 N. Caroline Street
Baltimore, MD 21287 map


Diagnostic Radiology

Research Interests

Functional MRI; Brain tumor imaging; Diffusion tensor imaging


Dr. Pillai graduated cum laude from Yale University and received his M.D. degree from Jefferson Medical College in Philadelphia. After internal medicine internship at North Shore U. Hosp-Cornell/Memorial Sloan-Kettering Cancer Center program, he completed radiology residency at Newark Beth Israel Med.Ctr.(affil. of Mount Sinai School of Medicine), where he was Chief Resident. He joined the Medical College of Georgia (MCG) faculty in 1999 after two year fellowship in neuroradiology at Case Western Reserve U./Univ. Hosp. of Cleveland. At MCG, he was Associate Professor of Radiology, Director of Neuro-Magnetic Resonance Imaging, and President of the School of Medicine Faculty Senate in 2006. He joined Johns Hopkins as Visiting Associate Professor in 2007 and is currently Associate Professor of Radiology and Radiological Science and Director of Functional MRI at Johns Hopkins.

Dr. Pillai has been on the Editorial Board of the American Journal of Neuroradiology since 2007 and is also on the editorial boards of Public Library of Science-One (PLoS-ONE)and the World Journal of Clinical Oncology. He currently receives grant funding from Siemens for work in fMRI, and has received research funding from NIH,RSNA (Radiological Society of North America) and the Johns Hopkins Brain Science Institute. His field of research and clinical interest includes functional imaging, particularly of brain tumors. He completed a term (2008-2009) as President of the American Society of Functional Neuroradiology (ASFNR) and has served on the Scientific Program Committee of the RSNA for the last six years, and he has been actively involved in the American Society of Neuroradiology (ASNR) and International Society for Magnetic Resonance in Medicine (ISMRM). more

    Additional Information

  • Education +


    • Jefferson Medical College of Thomas Jefferson University / MD (1992)


    • Newark Beth Israel Medical Center / Diagnostic Radiology (1997)


    • Case Western Reserve University / Neuroradiology (1999)


    • American Board of Radiology / Diagnostic Radiology (1997)
    • American Board of Radiology / Neuroradiology (2000, 2010)
  • Research & Publications +

    Research Summary

    Dr. Pillai’s main research interest is translating MR imaging methods into clinic for use with the Johns Hopkins brain tumor patient population. Dr. Pillai’s primary interest in validating MRI methods for interoperative mapping is focused on improving and coregistering BOLD functional maps, DTI color directional maps and structural information from MPRAGE images. The primary research aim is to improve and streamline data acquisition and processing into a fast and quantitative comprehensive multi-modality exam to validate and complement current techniques for interoperative mapping. Dr. Pillai’s secondary interest is understanding the clinical efficacy of perfusion-based imaging methods for characterizing brain tumors complements.

    Selected Publications View all on PubMed

    1. Zacà D, Jovicich J, Nadar SR, Voyvodic JT, Pillai JJ. "Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI." J Magn Reson Imaging. 2013 Nov 4. doi: 10.1002/jmri.24406.
    2. Zacà D, Jarso S, Pillai JJ. "Role of semantic paradigms for optimization of language mapping in clinical FMRI studies." AJNR Am J Neuroradiol. 2013 Oct;34(10):1966-71. doi: 10.3174/ajnr.A3628.
    3. Jones CK, Huang A, Xu J, Edden RA, Schär M, Hua J, Oskolkov N, Zacà D, Zhou J, McMahon MT, Pillai JJ, van Zijl PC. "Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T." Neuroimage. 2013 Aug 15;77:114-24. doi: 10.1016/j.neuroimage.2013.03.047.
    4. Pillai JJ. "The significance of streamlined postprocessing approaches for clinical FMRI." AJNR Am J Neuroradiol. 2013 Jun-Jul;34(6):1194-6. doi: 10.3174/ajnr.A3446.
    5. Pillai JJ, Williams HT, Forseen SE, Park YD. "Presurgical lateralization of seizure focus in temporal lobe epilepsy with noninvasive imaging." Clin Nucl Med. 2012 Dec;37(12):1179-81. doi: 10.1097/RLU.0b013e31825ae8d0.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Philips Medical Systems Seed Grant for work in functional MRI, Radiological Society of North America, 2000
    • Executive Committee, American Society of Neuroradiology, 2008 - 2009
    • President, American Society of Functional Neuroradiology (ASFNR), 2008 - 2009


    • Editorial board of the American Journal of Neuroradiology, 2007
    • Editorial boards of the Journal of the International Brain Mapping, PLoS-ONE (Public Library of Science) and the World Journal of Clinical Oncology
    • Radiological Society of North America (RSNA) Scientific Program Committee, 2007
  • Videos & Media +
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