Skip Navigation
Search Menu
Find an Expert


Jay Jan Pillai, M.D.

Photo of Dr. Jay Jan Pillai, M.D.

Director, Functional MR Imaging

Associate Professor of Radiology and Radiological Science


Expertise: Diagnostic Radiology

Research Interests: Functional MRI; Brain tumor imaging; Diffusion tensor imaging

Request an Appointment

I live in Maryland

Request an appointment through MyChart!

I live outside of Maryland

Request Appointment

I live outside of the United States

Request Appointment


The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 443-997-7237

1800 Orleans St.
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-550-0100

4940 Eastern Avenue
Baltimore, MD 21224 map

Johns Hopkins Outpatient Center
Appointment Phone: 443-997-7237

601 N. Caroline St.
Baltimore, MD 21287 map


Dr. Pillai graduated cum laude from Yale University and received his M.D. degree from Jefferson Medical College in Philadelphia. After internal medicine internship at North Shore U. Hospital - Cornell/Memorial Sloan-Kettering Cancer Center program, he completed radiology residency at Newark Beth Israel Med. Ctr. (affil. of Mount Sinai School of Medicine), where he was Chief Resident. He joined the Medical College of Georgia (MCG) faculty in 1999 after two year fellowship in neuroradiology at Case Western Reserve U./Univ. Hospital of Cleveland. At MCG, he was Associate Professor of Radiology, Director of Neuro-Magnetic Resonance Imaging, and President of the School of Medicine Faculty Senate in 2006. He joined Johns Hopkins as Visiting Associate Professor in 2007 and is currently Associate Professor of Radiology and Radiological Science and Director of Functional MRI at Johns Hopkins. 

Dr. Pillai has been on the Editorial Board of the American Journal of Neuroradiology since 2007 and is also on the editorial boards of Public Library of Science-One (PLoS-ONE) and the World Journal of Clinical Oncology. He currently receives grant funding from the NIH as co-PI to study brain lesion-induced neurovascular uncoupling and has previously received funding as PI on grants funded by Siemens, RSNA (Radiological Society of North America) and the Johns Hopkins Brain Science Institute; he has also served as co-investigator on other NIH-funded projects. His field of research and clinical interest includes functional imaging, particularly of brain tumors. He completed a term (2008-2009) as President of the American Society of Functional Neuroradiology (ASFNR) and has served for six years on the Scientific Program Committee of the RSNA in the past. He has most recently served a 3-year term on the Annual Meeting Program Committee (AMPC) of the International Society for Magnetic Resonance in Medicine (ISMRM). He has published two books (Functional Brain Tumor Imaging [Springer] & a Neuroimaging Clinics of North America issue entitled, “Clinical Applications of Functional MRI”[Elsevier]) in 2014. more


  • Director, Functional MR Imaging
  • Associate Professor of Radiology and Radiological Science
  • Associate Professor of Neurosurgery

Departments / Divisions



  • MD, Jefferson Medical College of Thomas Jefferson University (1992)


  • Newark Beth Israel Medical Center / Diagnostic Radiology (1997)


  • University Hospitals of Cleveland / Neuroradiology (1999)

Board Certifications

  • American Board of Radiology / Diagnostic Radiology (1997)
  • American Board of Radiology / Neuroradiology (2000)

Research & Publications

Research Summary

Dr. Pillai’s main research interest is translating MR imaging methods into clinic for use with the Johns Hopkins brain tumor patient population. Dr. Pillai’s primary interest in validating MRI methods for interoperative mapping is focused on improving and coregistering BOLD functional maps, DTI color directional maps and structural information from MPRAGE images. The primary research aim is to improve and streamline data acquisition and processing into a fast and quantitative comprehensive multi-modality exam to validate and complement current techniques for interoperative mapping. Dr. Pillai’s secondary interest is understanding the clinical efficacy of perfusion-based imaging methods for characterizing brain tumors complements.

Selected Publications

View all on Pubmed

  1. Zacà D, Jovicich J, Nadar SR, Voyvodic JT, Pillai JJ. "Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI." J Magn Reson Imaging. 2013 Nov 4. doi: 10.1002/jmri.24406.
  2. Zacà D, Jarso S, Pillai JJ. "Role of semantic paradigms for optimization of language mapping in clinical FMRI studies." AJNR Am J Neuroradiol. 2013 Oct;34(10):1966-71. doi: 10.3174/ajnr.A3628.
  3. Jones CK, Huang A, Xu J, Edden RA, Schär M, Hua J, Oskolkov N, Zacà D, Zhou J, McMahon MT, Pillai JJ, van Zijl PC. "Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T." Neuroimage. 2013 Aug 15;77:114-24. doi: 10.1016/j.neuroimage.2013.03.047.
  4. Pillai JJ. "The significance of streamlined postprocessing approaches for clinical FMRI." AJNR Am J Neuroradiol. 2013 Jun-Jul;34(6):1194-6. doi: 10.3174/ajnr.A3446.
  5. Pillai JJ, Williams HT, Forseen SE, Park YD. "Presurgical lateralization of seizure focus in temporal lobe epilepsy with noninvasive imaging." Clin Nucl Med. 2012 Dec;37(12):1179-81. doi: 10.1097/RLU.0b013e31825ae8d0.

Activities & Honors


  • President, American Society of Functional Neuroradiology (ASFNR), 2008 - 2009
  • Executive Committee, American Society of Neuroradiology, 2008 - 2009
  • Philips Medical Systems Seed Grant for work in functional MRI, Radiological Society of North America, 2000


  • Editorial board of the American Journal of Neuroradiology, 2007
  • Editorial boards of the Journal of the International Brain Mapping, PLoS-ONE (Public Library of Science) and the World Journal of Clinical Oncology
  • Radiological Society of North America (RSNA) Scientific Program Committee, 2007
Is this you? Edit Profile