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Photo of Dr. Karl Lee Womer, MD

Karl L. Womer, MD

Karl Lee Womer, MD
Clinical Director, Transplant Nephrology
Associate Professor of Medicine
Male
Appointment Phone

410-955-0670

Primary Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Clinical Director, Transplant Nephrology
  • Associate Professor of Medicine

Centers & Institutes

  • Comprehensive Transplant Center

Expertise

Incompatible Kidney Transplant, Kidney Transplant, Nephrology, Pancreas Transplant

Biography

Dr. Womer was awarded his MD degree from The University of Alabama School of Medicine in Birmingham, AL. His Internal Medicine training was completed at Barnes-Jewish Hospital at Washington University School of Medicine in St. Louis, MO. His clinical and research training was in the Division of Nephrology at Brigham & Women’s Hospital – Harvard Medical School in Boston, MA. Dr. Womer is currently Clinical Director of Transplant Nephrology and manages medical kidney transplant recipients in both inpatient and outpatient settings, including medical evaluation of potential live kidney donors. Research interests include dendritic cell immunobiology in the transplant setting, including experimental animal models of transplantation on a basic level and clinical translational work in patients with BK virus nephropathy.

Languages

  • English
  • German

Additional Resources

Additional Resources +
  • Education +

    Training

    • University of Alabama at Birmingham ( Birmingham AL ) (1993)

    Residencies

    • Washington University School of Nurse Anesthesia - Barnes Hospital/Internal Medicine ( St Louis MO ) (1996)

    Fellowships

    • Brigham and Women's Hospital ( Boston MA ) (2001)
    • Brigham and Women's Hospital/Nephrology ( Boston MA ) (1998)

    Certifications

    • Nephrology, American Board of Internal Medicine (2012)
  • Research & Publications +

    Selected Publications

    1. Q Sun; E C Hall; Y Huang; P Chen; K Dibadj; M Murawski; R Shraybman; K Van Kirk; V Tang; R Peng; et al. Pre-transplant myeloid dendritic cell deficiency associated with cytomegalovirus infection and death after kidney transplantation. Transplant infectious disease : an official journal of the Transplantation Society 2012;14(6):618-25. 2012 
    2. Adnan Sharif; Nada Alachkar; Serena Bagnasco; Duvuru Geetha; Gaurav Gupta; Karl Womer; Lois Arend; Lorraine Racusen; Robert Montgomery; Edward Kraus; Incidence and outcomes of BK virus allograft nephropathy among ABO- and HLA-incompatible kidney transplant recipients. Clinical journal of the American Society of Nephrology : CJASN 2012;7(8):1320-7. 2012 
    3. Zuoxiang Xiao; Abdiaziz S Mohamood; Sophia Uddin; Rachel Gutfreund; Chiaki Nakata; Andrew Marshall; Hiroaki Kimura; Patrizio Caturegli; Karl L Womer; Yanfei Huang; et al. Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development. The American journal of pathology 2011;179(2):725-32. 2011 
    4. Gang Jee Ko; Hye Ryoun Jang; Yanfei Huang; Karl L Womer; Manchang Liu; Elizabeth Higbee; Zuoxiang Xiao; Hideo Yagita; Lorraine Racusen; Abdel Rahim A Hamad; et al. Blocking Fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN 2011;22(4):732-42. 2011 
    5. Yanfei Huang; Ping Chen; Cassie B Zhang; Gang Jee Ko; Miriam Ruiz; Paolo Fiorina; Mehboob A Hussain; Barbara A Wasowska; Hamid Rabb; Karl L Womer; Kidney-derived mesenchymal stromal cells modulate dendritic cell function to suppress alloimmune responses and delay allograft rejection. Transplantation 2010;90(12):1307-11. 2010 
    6. N Alachkar; R Ugarte; E Huang; K L Womer; R Montgomery; E Kraus; H Rabb; Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function. Transplantation proceedings 2010;42(9):3399-405. 2010 
    7. Gang Jee Ko; Asif Zakaria; Karl L Womer; Hamid Rabb; Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University. Immunologic research 2010;47(1-3):78-85. 2010 
    8. M E Allaf; A Singer; W Shen; I Green; K Womer; D L Segev; R A Montgomery; Laparoscopic live donor nephrectomy with vaginal extraction: initial report. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(6):1473-7. 2010 
    9. M E Grams; K L Womer; R M Ugarte; N M Desai; R A Montgomery; D L Segev; Listing for expanded criteria donor kidneys in older adults and those with predicted benefit. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(4):802-9. 2010 
    10. Karl L Womer; Yanfei Huang; Heather Herren; Kourosh Dibadj; Ruihua Peng; Matthew Murawski; Renata Shraybman; Pamela Patton; Michael J Clare-Salzler; Bruce Kaplan; Dendritic cell deficiency associated with development of BK viremia and nephropathy in renal transplant recipients. Transplantation 2010;89(1):115-23. 2010 
    11. Gaurav Gupta; Karl L Womer; Profile of belatacept and its potential role in prevention of graft rejection following renal transplantation. Drug design, development and therapy 2010;4():375-82. 2010 
    12. K L Womer; B Kaplan; Recent developments in kidney transplantation--a critical assessment. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(6):1265-71. 2009 
    13. Yanfei Huang; Matthew Parker; Changqing Xia; Ruihua Peng; Clive Wasserfall; Tracy Clarke; Lizhen Wu; Tayseer Chowdhry; Martha Campbell-Thompson; John Williams; et al. Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses. Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4608-15. 2009 
    14. Yanfei Huang; Peter Johnston; Borui Zhang; Asif Zakari; Tayseer Chowdhry; Rachel Ruckdeschel Smith; Eduardo Marbán; Hamid Rabb; Karl L Womer; Kidney-derived stromal cells modulate dendritic and T cell responses. Journal of the American Society of Nephrology : JASN 2009;20(4):831-41. 2009 
    15. Edmund Huang; Millie Samaniego-Picota; Thomas McCune; Joseph K Melancon; Robert A Montgomery; Richard Ugarte; Edward Kraus; Karl Womer; Hamid Rabb; Terry Watnick; DNA testing for live kidney donors at risk for autosomal dominant polycystic kidney disease. Transplantation 2009;87(1):133-7. 2009 
    16. Asif Zakaria; Yanfei Huang; Karl Womer; Hamid Rabb; Diverse sources of stem cells to treat acute kidney injury. Nephron. Experimental nephrology 2009;112(1):e29-30. 2009 
    17. Karl L Womer; Colm C Magee; Nader Najafian; John P Vella; Edgar L Milford; Mohamed H Sayegh; Charles B Carpenter; A pilot study on the immunological effects of oral administration of donor major histocompatibility complex class II peptides in renal transplant recipients. Clinical transplantation 2008;22(6):754-9. 2008 
    18. Karl L Womer; Pamela R Patton; Bruce Kaplan; Aggressive post-transplant monitoring of more importance to successful outcome following re-transplantation for BK virus nephropathy than absence of pretransplant viremia. Transplant international : official journal of the European Society for Organ Transplantation 2008;21(11):1103-4. 2008 
    19. Greg Simon; Matthew Parker; Vijayakumar Ramiya; Clive Wasserfall; Yanfei Huang; Damien Bresson; R Fletcher Schwartz; Martha Campbell-Thompson; Lauren Tenace; Todd Brusko; et al. Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation. Diabetes 2008;57(2):405-14. 2008 
    20. K L Womer; G Guerra; K Dibadj; Y Huang; A Kazory; B Kaplan; T R Srinivas; Immunosuppression reduction for BK virus nephropathy: a case for caution. Transplant infectious disease : an official journal of the Transplantation Society 2007;9(3):244-8. 2007 
    21. Yanfei Huang; Hamid Rabb; Karl L Womer; Ischemia-reperfusion and immediate T cell responses. Cellular immunology 2007;248(1):4-11. 2007 
    22. Alan D Salama; Karl L Womer; Mohamed H Sayegh; Clinical transplantation tolerance: many rivers to cross. Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5419-23. 2007 
    23. JogiRaju Tantravahi; Karl L Womer; Bruce Kaplan; Why hasn't eliminating acute rejection improved graft survival? Annual review of medicine 2007;58():369-85. 2007 
    24. Titte R Srinivas; Jesse D Schold; Karl L Womer; Bruce Kaplan; Richard J Howard; Charles M Bucci; Herwig-Ulf Meier-Kriesche; Improvement in hypercalcemia with cinacalcet after kidney transplantation. Clinical journal of the American Society of Nephrology : CJASN 2006;1(2):323-6. 2006 
    25. K L Womer; H-U Meier-Kriesche; P R Patton; K Dibadj; C M Bucci; D Foley; S Fujita; B P Croker; R J Howard; T R Srinivas; et al. Preemptive retransplantation for BK virus nephropathy: successful outcome despite active viremia. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(1):209-13. 2006 
    26. Karl L Womer; Ruihua Peng; Pamela R Patton; Matthew R Murawski; Michael Bucci; Ayesha Kaleem; Jesse Schold; Phillip A Efron; Alan W Hemming; T R Srinivas; et al. The effects of renal transplantation on peripheral blood dendritic cells. Clinical transplantation 2005;19(5):659-67. 2005
    27. Karl L Womer; Transplantation tolerance. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2005;16(4):498-505. 2005 
    28. K L Womer; R Peng; P R Patton; A Kaleem; M Bucci; M R Murawski; J Schold; P A Efron; A W Hemming; T R Srinivas; et al. The effects of renal transplantation on circulating precursor dendritic cells. Transplantation proceedings 2005;37(1):3-6. 2005 
    29. Bruce Kaplan; Jesse Schold; Titte Srinivas; Karl Womer; David P Foley; Pamela Patton; Richard Howard; Herwig-Ulf Meier-Kriesche; Effect of sirolimus withdrawal in patients with deteriorating renal function. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(10):1709-12. 2004 
    30. Colm C Magee; Mark D Denton; Karl L Womer; Samia J Khoury; Mohamed H Sayegh; Assessment by flow cytometry of intracellular cytokine production in the peripheral blood cells of renal transplant recipients. Clinical transplantation 2004;18(4):395-401. 2004
    31. Karl L Womer; Mohamed H Sayegh; Donor antigen and transplant tolerance strategies: it takes two to tango! Journal of the American Society of Nephrology : JASN 2004;15(4):1101-3. 2004 
    32. Joana E Kist-van Holthe; Martin Gasser; Karl Womer; Nader Najafian; Victor Dong; Dimitry V Samsonov; Chris S Geehan; Anil Chandraker; Mohamed H Sayegh; Ana Maria Waaga; Regulatory functions of alloreactive Th2 clones in human renal transplant recipients. Kidney international 2002;62(2):627-31. 2002 
    33. K L Womer; J R Stone; B Murphy; A Chandraker; M H Sayegh; Indirect allorecognition of donor class I and II major histocompatibility complex peptides promotes the development of transplant vasculopathy. Journal of the American Society of Nephrology : JASN 2001;12(11):2500-6. 2001 
    34. S I Reznik; A Jaramillo; K S SivaSai; K L Womer; M H Sayegh; E P Trulock; G A Patterson; T Mohanakumar; Indirect allorecognition of mismatched donor HLA class II peptides in lung transplant recipients with bronchiolitis obliterans syndrome. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2001;1(3):228-35. 2001 
    35. K L Womer; M H Sayegh; H Auchincloss; Involvement of the direct and indirect pathways of allorecognition in tolerance induction. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):639-47. 2001
    36. K L Womer; R S Lee; J C Madsen; M H Sayegh; Tolerance and chronic rejection. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):727-38. 2001 
    37. A M Waaga; M Gasser; J E Kist-van Holthe; N Najafian; A Müller; J P Vella; K L Womer; A Chandraker; S J Khoury; M H Sayegh; Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo.  The Journal of clinical investigation 2001;107(7):909-16. 2001 
    38. R S Lee; K Yamada; S L Houser; K L Womer; M E Maloney; H S Rose; M H Sayegh; J C Madsen; Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy. Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3276-81. 2001 
    39. R S Lee; K Yamada; S L Houser; K L Womer; M E Maloney; H S Rose; M H Sayegh; J C Madsen; Indirect allorecognition promotes the development of cardiac allograft vasculopathy. Transplantation proceedings 2001;33(1-2):308-10. 2001 
    40. R S Lee; K Yamada; K L Womer; E P Pillsbury; K S Allison; A E Marolewski; D Geng; A D Thall; J S Arn; D H Sachs; et al. Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses. Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3434-44. 2000 
    41. K L Womer; J P Vella; M H Sayegh; Chronic allograft dysfunction: mechanisms and new approaches to therapy. Seminars in nephrology 2000;20(2):126-47. 2000 
    42. V M Dong; K L Womer; M H Sayegh, Transplantation tolerance: the concept and its applicability. Pediatric transplantation 1999;3(3):181-92. 1999 
    43. J P Vella; C Magee; L Vos; K Womer; H Rennke; C B Carpenter; W Hancock; M H Sayegh; Cellular and humoral mechanisms of vascularized allograft rejection induced by indirect recognition of donor MHC allopeptides. Transplantation 1999;67(12):1523-32. 1999 
  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +

    Videos

    What Kidney Donors Need to Know: Before, During, and After

    Medical Management Kidney Donors

  • Upcoming Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-0670
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Appointment Phone: 410-955-0670
    Location Map

    Department/Division

    • Medicine - Nephrology

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