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Charles Steenbergen, Jr, M.D., Ph.D.

Photo of Dr. Charles Steenbergen, Jr, M.D., Ph.D.

Professor of Pathology

Male

Expertise: Cardiovascular Pathology, Pathology, Transplant Pathology

Research Interests: Cardiovascular Diseases, particularly Ischemia-Reperfusion Injury

Locations

The Johns Hopkins Hospital
Appointment Phone: 410-502-5982

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center
Appointment Phone: 410-502-5982

601 N. Caroline St.
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-502-5982

4940 Eastern Avenue
Baltimore, MD 21224 map

Background

Dr. Charles Steenbergen is a professor of pathology at the Johns Hopkins University School of Medicine. He specializes in cardiovascular and transplant pathology, with particular focus on the mechanisms of ischemic heart disease.

Dr. Steenbergen received an M.D. and a Ph.D. from the University of Pennsylvania. He completed a residency in anatomic pathology and a fellowship in pathology at Duke University.

He is certified in anatomic pathology by the American Board of Pathology.

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Titles

  • Professor of Pathology

Departments / Divisions

Education

Degrees

  • MD, University of Pennsylvania School of Medicine (1978)

Residencies

  • Duke University School of Medicine / Anatomic Pathology (1984)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (1985)

Research & Publications

Research Summary

Dr. Steenbergen’s research focuses on mechanisms of ischemic heart disease, and in particular, endogenous mechanisms that can be activated to protect the heart during a subsequent episode of ischemia and reperfusion.

He is interested in identifying signal transduction pathways that are involved in cardioprotection, and understanding how these signaling pathways confer their protective effect.

His lab studies the mechanisms of injury involving ionic dysequilibrium, and has used magnetic resonance spectroscopic techniques to monitor ion concentrations in intact hearts during ischemia and reperfusion. Since infarct size is a major determinant of clinical outcome in patients with ischemic heart disease, the lab hopes that better understanding of these protective mechanisms will lead to the development of better therapies for patients with coronary artery disease and patients undergoing heart surgery.

Selected Publications

Murphy, E. and Steenbergen, C.: Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol. Rev. 2008; 88: 581-609.

Das, S., Ferlito, M., Kent, O.A., Fox-Talbot, K., Wang, R., Liu, D., Raghavachari, N., Yang, Y., Wheelan, S.J., Murphy, E., Steenbergen, C. Nuclear miRNA regulates the mitochondrial genome in the heart. Circ. Res. 2012; 110: 1596-1603.

Yano, T., Ferlito, M., Aponte, A., Kuno, A., Miura, T., Murphy, E., Steenbergen, C. Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling. Circ. Res. 2014; 114: 1268-1280.

Kohr, M.J., Murphy, E., Steenbergen, C. Glyceraldehyde-3-phosphate dehydrogenase acts as a mitochondrial trans-S-nitrosylase in the heart. PLoS One. 2014; 9: e111448.

Sun, J., Nguyen, T., Aponte, A.M., Menazza, S., Kohr, M.J., Roth, D. M. Patel, H.H., Murphy, E., Steenbergen, C. Ischemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc. Res. 2015; 106: 227-236.

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