Skip Navigation
Search Menu
Find an Expert


Photo of Dr. Charles Steenbergen, Jr, M.D., Ph.D.

Charles Steenbergen, Jr, M.D., Ph.D.

Professor of Pathology


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Professor of Pathology

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-502-5982

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-502-5982

601 N. Caroline Street
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-502-5982

4940 Eastern Avenue
Baltimore, MD 21224 map


Cardiovascular Pathology, Pathology, Transplant Pathology

Research Interests

Cardiovascular Diseases, particularly Ischemia-Reperfusion Injury


Dr. Charles Steenbergen is a professor of pathology at the Johns Hopkins University School of Medicine. He specializes in cardiovascular and transplant pathology, with particular focus on the mechanisms of ischemic heart disease.

Dr. Steenbergen received an M.D. and a Ph.D. from the University of Pennsylvania. He completed a residency in anatomic pathology and a fellowship in pathology at Duke University.

He is certified in anatomic pathology by the American Board of Pathology. more

    Additional Information

  • Education +


    • University of Pennsylvania School of Medicine / MD (1978)


    • Duke University School of Medicine / Anatomic Pathology (1984)


    • American Board of Pathology / Anatomic Pathology (1985)
  • Research & Publications +

    Research Summary

    Dr. Steenbergen’s research focuses on mechanisms of ischemic heart disease, and in particular, endogenous mechanisms that can be activated to protect the heart during a subsequent episode of ischemia and reperfusion.

    He is interested in identifying signal transduction pathways that are involved in cardioprotection, and understanding how these signaling pathways confer their protective effect.

    His lab studies the mechanisms of injury involving ionic dysequilibrium, and has used magnetic resonance spectroscopic techniques to monitor ion concentrations in intact hearts during ischemia and reperfusion. Since infarct size is a major determinant of clinical outcome in patients with ischemic heart disease, the lab hopes that better understanding of these protective mechanisms will lead to the development of better therapies for patients with coronary artery disease and patients undergoing heart surgery.

    Selected Publications

    Murphy, E. and Steenbergen, C.: Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol. Rev. 2008; 88: 581-609.

    Das, S., Ferlito, M., Kent, O.A., Fox-Talbot, K., Wang, R., Liu, D., Raghavachari, N., Yang, Y., Wheelan, S.J., Murphy, E., Steenbergen, C. Nuclear miRNA regulates the mitochondrial genome in the heart. Circ. Res. 2012; 110: 1596-1603.

    Yano, T., Ferlito, M., Aponte, A., Kuno, A., Miura, T., Murphy, E., Steenbergen, C. Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling. Circ. Res. 2014; 114: 1268-1280.

    Kohr, M.J., Murphy, E., Steenbergen, C. Glyceraldehyde-3-phosphate dehydrogenase acts as a mitochondrial trans-S-nitrosylase in the heart. PLoS One. 2014; 9: e111448.

    Sun, J., Nguyen, T., Aponte, A.M., Menazza, S., Kohr, M.J., Roth, D. M. Patel, H.H., Murphy, E., Steenbergen, C. Ischemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc. Res. 2015; 106: 227-236.

  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
Is This You? Edit Profile