Dr. Mari is a team member of the Johns Hopkins Morris K. Udall Parkinson's Disease Research Center of Excellence where he reviews all charts and sees all patients enrolled in the Longitudinal Study at the Udall Center. He is the senior author of a research effort titled “Factors Associated with Falls in Parkinson's Disease”, a project that made use of the Longitudinal Dataset acquired as part of the main clinical research activities at Udall Center and was recently accepted as an abstract publication to the 15th International Congress of Parkinson’s Disease and Movement Disorders.
Dr Mari's research focuses on clinical trials in Parkinson’s disease modification and neuroprotection, and the neurophysiology of and motor control in movement disorders, with particular interest in basal ganglia pathophysiology in dystonia. In his leadership of the Deep Brain Stimulation Program at Johns Hopkins Hospital he has been the principal investigator on multiple major NIH-funded clinical trials on neuroprotection in Parkinson disease, including the NET-PD and QEIII trials (to investigate the possible disease modifying effect of creatine and Coenzyme Q10, respectively).
Learn more about active clinical trials taking place at the Johns Hopkins Parkinson’s Disease and Movement Disorders Center.
Clinical Trial Keywords:
Botulinum toxin type B injection in the treatment of sialorrhea (drooling or excessive salivation), movement disorders, Parkinson's disease, neuroprotection
Salimpour Y, Mari Z, Shadmehr R. Altering Effort Costs in Parkinson's Disease with Noninvasive Cortical Stimulation. J Neurosci. 2015 Sep 2;35(35):12287-302. doi: 10.1523/JNEUROSCI.1827-15.2015. PMID: 26338339
Brandt J, Rogerson M, Al-Joudi H, Reckess G, Shpritz B, Umeh CC, Aljehani N, Mills K, Mari Z. Betting on DBS: Effects of Subthalamic Nucleus Deep Brain Stimulation on Risk Taking and Decision Making in Patients With Parkinson's Disease. Neuropsychology. 2014 Dec 8. [Epub ahead of print] PMID: 25486385
Han Y, Stevens A, Dashtipour K, Hauser R, Mari Z. A Mixed Treatment Comparison (Mtc) To Compare The Efficacy Of Botulinum Toxin Type A Treatments For Cervical Dystonia. Value in Health. 05/2014; 17(3):A57. DOI: 10.1016/j.jval.2014.03.335
Mills K, Mari Z. An Update and Review of the Treatment of Myoclonus. Curr Neurol Neurosci Rep. 2015 Jan;15(1):512. doi: 10.1007/s11910-014-0512-2. PMID: 25398378
Mahajan A, Gamaldo C, Salas RM, Pontone G, Umeh C, Rosenthal L, McCoy A, Mari Z. REM sleep behavior and motor findings in Parkinson’s disease: a cross sectional analysis. Tremor Other Hyperkinet Mov (N Y). 2014 Jun 23;4:245. doi: 10.7916/D84B2ZDF. eCollection 2014
Mari Z, Halls AJM, Vortmeyer A, Zhukareva V, Uryu K, Lee VMY, Hallett, M. Clinico-Pathological Correlation in Progressive Ataxia and Palatal Tremor: A Novel Tauopathy. Movement Disorders Clinical Practice 04/2014; 1(1). DOI:10.1002/mdc3.12014