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Zoltan Mari, M.D.

Photo of Dr. Zoltan Mari, M.D.

Director, Johns Hopkins Parkinsons and Movement Disorder Center; Director, Johns Hopkins Movement Disorders Fellowship

Associate Professor of Neurology


Languages: English, Hungarian

Expertise: Botulinum Toxin Injections, Clinical Neurophysiology, Deep Brain Stimulation, Dystonia, Intraoperative Neuromonitoring, Movement Disorders, Neurology, Parkinson's Disease more

Research Interests: deep brain stimulation; electrophysiology; chemodenervation; neuroprotection; dystonia

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The Johns Hopkins Hospital
Appointment Phone: 410-502-0133

600 N. Wolfe Street
Meyer Building 6-181B
Baltimore, MD 21287 map
Phone: 410-502-0133
Fax: 410-502-6737

Johns Hopkins Outpatient Center
Appointment Phone: 410-955-9441

601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-502-0133


As the director of the Johns Hopkins Parkinson’s Disease and Movement Disorders Center, Dr. Zoltan Mari's clinical practice focuses on movement disorders, including Parkinson's disease and related syndromes, essential tremor and dystonia, with particular interest in deep brain stimulation (DBS) therapy and botulinum toxin injections for sialorrhea (drooling or excessive salivation). His clinical interests also include clinical neurophysiology, including nerve conduction/electromyography and intra-operative monitoring.

Zoltan Mari, M.D., graduated first in his Medical School class at the University of Szeged, Hungary. His training includes residency in neurology (SUNY Downstate, Brooklyn, NY), fellowship in movement disorders and clinical neurophysiology with EMG emphasis (both at NIH, Bethesda, MD), and Clinical Research Curriculum Certificate (NIH). He is board certified in neurology and clinical neurophysiology by ABPN. During his senior fellowship years Dr. Mari served as Director of the NIH Botulinum Toxin Clinic and was featured in CBSs 60 minutes, as the injector of the pianist Leon Fleisher. Dr. Mari received travel awards from the AAN and ANA during his training years. more


  • Director, Johns Hopkins Parkinsons and Movement Disorder Center; Director, Johns Hopkins Movement Disorders Fellowship
  • Director, Movement Disorder Fellowship Training Program
  • Director, Dystonia and Chemodenervation Center
  • Director, Deep Brain Stimulation Center
  • Associate Professor of Neurology

Departments / Divisions



  • MD, Albert Szent-Gyorgyi Medical University University of Szeged (1993)


  • SUNY Downstate Medical Center - College of Medicine / Neurology (2017)


  • National Institutes of Health-Credentialing Services Section / Movement Disorders (2017)
  • National Institutes of Health-Credentialing Services Section / Neurophysiology (2017)

Board Certifications

  • American Board of Psychiatry & Neurology / Clinical Neurophysiology (2007)

Research & Publications


Dr. Mari is a team member of the Johns Hopkins Morris K. Udall Parkinson's Disease Research Center of Excellence where he reviews all charts and sees all patients enrolled in the Longitudinal Study at the Udall Center. He is the senior author of a research effort titled “Factors Associated with Falls in Parkinson's Disease”, a project that made use of the Longitudinal Dataset acquired as part of the main clinical research activities at Udall Center and was recently accepted as an abstract publication to the 15th International Congress of Parkinson’s Disease and Movement Disorders.

Dr Mari's research focuses on clinical trials in Parkinson’s disease modification and neuroprotection, and the neurophysiology of and motor control in movement disorders, with particular interest in basal ganglia pathophysiology in dystonia. In his leadership of the Deep Brain Stimulation Program at Johns Hopkins Hospital he has been the principal investigator on multiple major NIH-funded clinical trials on neuroprotection in Parkinson disease, including the NET-PD and QEIII trials (to investigate the possible disease modifying effect of creatine and Coenzyme Q10, respectively). 

Clinical Trial Keywords

Botulinum toxin type B injection in the treatment of sialorrhea (drooling or excessive salivation), movement disorders, Parkinson's disease, neuroprotection

Clinical Trials

Learn more about active clinical trials taking place at the Johns Hopkins Parkinson’s Disease and Movement Disorders Center.

Selected Publications

Salimpour Y, Mari Z, Shadmehr R. Altering Effort Costs in Parkinson's Disease with Noninvasive Cortical Stimulation. J Neurosci. 2015 Sep 2;35(35):12287-302. doi: 10.1523/JNEUROSCI.1827-15.2015. PMID: 26338339

Brandt J, Rogerson M, Al-Joudi H, Reckess G, Shpritz B, Umeh CC, Aljehani N, Mills K, Mari Z. Betting on DBS: Effects of Subthalamic Nucleus Deep Brain Stimulation on Risk Taking and Decision Making in Patients With Parkinson's Disease. Neuropsychology. 2014 Dec 8. [Epub ahead of print] PMID: 25486385

Han Y, Stevens A, Dashtipour K, Hauser R, Mari Z. A Mixed Treatment Comparison (Mtc) To Compare The Efficacy Of Botulinum Toxin Type A Treatments For Cervical Dystonia. Value in Health. 05/2014; 17(3):A57. DOI: 10.1016/j.jval.2014.03.335

Mills K, Mari Z. An Update and Review of the Treatment of Myoclonus. Curr Neurol Neurosci Rep. 2015 Jan;15(1):512. doi: 10.1007/s11910-014-0512-2. PMID: 25398378

Mahajan A, Gamaldo C, Salas RM, Pontone G, Umeh C, Rosenthal L, McCoy A, Mari Z. REM sleep behavior and motor findings in Parkinson's disease: a cross sectional analysis. Tremor Other Hyperkinet Mov (N Y). 2014 Jun 23;4:245. doi: 10.7916/D84B2ZDF. eCollection 2014

Mari Z, Halls AJM, Vortmeyer A, Zhukareva V, Uryu K, Lee VMY, Hallett, M. Clinico-Pathological Correlation in Progressive Ataxia and Palatal Tremor: A Novel Tauopathy. Movement Disorders Clinical Practice 04/2014; 1(1). DOI:10.1002/mdc3.12014

Activities & Honors


  • Elected Housestaff Membership in ETA Chapter of New York, Alpha Omega Alpha Honor Medical Society, 2001
  • Award, Preparing for the Future, American Neurological Association, 1999
  • 4. Intern of The Year title with a bronze plaque and $100 cash prize granted by the Dept. of Medicine, Brookdale University Hospital, 1997 - 1998
  • TEMPUS, EU, 1992
  • Government Scholarship, Hungarian Republic, 1991 - 1993
  • 8. AAN Resident Scholarship Award recipient ($1000 toward the 2001 AAN annual meeting in Philadelphia), Philadelphia, 2001
  • 9. ANA Travel Fellowship Award recipient ($1000 toward the 2005 ANA annual meeting in San Diego), San Diego, 2005
  • Travel Grant, Soros Foundation, 1994
  • Appointment as Chief Resident in Neurology, SUNY HSCB, 2000 - 2001
  • Teaching Award, Zoltan Maris Movement Disorder Clinic, 2011


  • Alpha Omega Alpha Honor Medical Society
    Housestaff Membership in ETA Chapter of New York since the 2000-2001 Academic Year, lifetime membership
  • American Academy of Neurology, 1998
  • American Association of Neuromuscular & Electrodiagnostic Medicine, 2005
  • American Medical Association, 1997
  • Clinical Neurophysiology Section, 2002
  • Movement Disorders Section, 2002
  • Movement Disorders Society, 2001
  • Society for Neuroscience, 2005

Videos & Media

Patient Video: Dystonia - Jeffrey's Story

Lectures and Presentations

  • Parkinson''s Disease Overview: Quo Vadis?
    PFNCA Annual Symposium 2013 (11/21/2013)

Recent News Articles and Media Coverage

NPR's the Diane Rehm show, An Update on Parkinson's Research and One Man's Personal Journey with the Disease (05/05/14)

NPR's the Diane Rehm show. Hear Dr. Mari discuss the latest treatment options, read the transcript or read the QA. (10/24/13)

HUB, Parkinson's in prime time: What it means for disease research, awareness (09/30/13)

AARP Magazine, "Linda Ronstadt: New Parkinson’s Therapies May Help You to Sing" (08/27/13)

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