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Lei Zheng, M.D., Ph.D.

Photo of Dr. Lei Zheng, M.D., Ph.D.

Associate Professor of Oncology


Languages: English, Chinese

Expertise: Anal Cancer, Bile Duct Cancer, Carcinoid Syndrome, Carcinoid Tumors, Cholangiocarcinoma, Colon Cancer, Colorectal Cancer, Gastric Cancer, Gastroesophageal Junction Cancer, Gastrointestinal Cancers, Gastrointestinal Tumors, Hepatocellular Cancer, Liver Cancer, Medical Oncology, Neuroendocrine Tumors, Pancreatic Cancer, Peri-Ampullar Cancer, Rectal Cancer, Small Bowel Cancer, Small Intestine Cancer, Stomach Cancer more

Research Interests: Pancreatic cancer biology and translational research; translational immunology and cancer immunotherapy; tumor microenvironment; cancer invasion and metastasis; clinical and translation research of gastrointestinal malignancies. more

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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-955-8964

401 N. Broadway
Baltimore, MD 21231 map



  • MD, Peking Union Medical College Beijing (1996)


  • Long Island Jewish Medical Center / Internal Medicine (2006)


  • Johns Hopkins University School of Medicine / Medical Oncology (2009)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (2006)
  • American Board of Internal Medicine / Medical Oncology (2008)

Research & Publications

Selected Publications

Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell. 2000;6(4):757-68.

Zheng L, Roeder RG, Luo Y. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell. 2003;114(2):255-66.

Lutz ER, Wu AA, Bigelow E, Sharma R, Mo G, Soares K, Solt S, Dorman A, Wamwea A, Yager A, Laheru D, Wolfgang CL, Wang J, Hruban RH,. Anders RA, Jaffee EM, Zheng L. Immunotherapy Converts Non-immunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation. Cancer Immunology Research 2014;2(7):1-16. (Corresponding author). PMCID: PMC4082460

Foley K, Rucki AA, Xiao Q, Zhou D, Leubner A, Mo G, Kleponis J, Wu AA, Sharma R, Jiang Q, Anders RA, Iacobuzio-Donahue CA, Hajjar KA, Maitra A, Jaffee EM, Zheng L. Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer. Science Signaling 2015; 8(388):ra77. (Corresponding author) PMCID in progress.

Soares KC, Rucki AA, Wu AA, Olino K, Xiao Q, Chai Y, Wamwea A, Bigelow E, Lutz E, Liu L, Yao S, Anders AA, Laheru D, Wolfgang CL, Edil BH, Schulick RD, Jaffee EM, Zheng L. PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T cell infiltration into pancreatic tumors. Journal of Immunotherapy 2015;38(1):1-11. (Corresponding author). PMCID: PMC4258151

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