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School of Medicine
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Lei Zheng, M.D., Ph.D.
Associate Professor of Oncology
Languages: English, Chinese
Expertise: Anal Cancer, Bile Duct Cancer, Carcinoid Syndrome, Carcinoid Tumors, Cholangiocarcinoma, Colon Cancer, Colorectal Cancer, Gastric Cancer, Gastroesophageal Junction Cancer, Gastrointestinal Cancers, Gastrointestinal Tumors, Hepatocellular Cancer, Liver Cancer, Medical Oncology, Neuroendocrine Tumors, Pancreatic Cancer, Peri-Ampullar Cancer, Rectal Cancer, Small Bowel Cancer, Small Intestine Cancer, Stomach Cancer ...read more
Research Interests: Pancreatic cancer biology and translational research; translational immunology and cancer immunotherapy; tumor microenvironment; cancer invasion and metastasis; clinical and translation research of gastrointestinal malignancies. ...read more
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-955-8964
401 N. Broadway
Baltimore, MD 21231 map
- Associate Professor of Oncology
- Associate Professor of Surgery
- MD, Peking Union Medical College Beijing (1996)
- Long Island Jewish Medical Center / Internal Medicine (2006)
- Johns Hopkins University School of Medicine / Medical Oncology (2009)
- American Board of Internal Medicine / Medical Oncology (2008)
Research & Publications
Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell. 2000;6(4):757-68.
Zheng L, Roeder RG, Luo Y. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell. 2003;114(2):255-66.
Lutz ER, Wu AA, Bigelow E, Sharma R, Mo G, Soares K, Solt S, Dorman A, Wamwea A, Yager A, Laheru D, Wolfgang CL, Wang J, Hruban RH,. Anders RA, Jaffee EM, Zheng L. Immunotherapy Converts Non-immunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation. Cancer Immunology Research 2014;2(7):1-16. (Corresponding author). PMCID: PMC4082460
Foley K, Rucki AA, Xiao Q, Zhou D, Leubner A, Mo G, Kleponis J, Wu AA, Sharma R, Jiang Q, Anders RA, Iacobuzio-Donahue CA, Hajjar KA, Maitra A, Jaffee EM, Zheng L. Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer. Science Signaling 2015; 8(388):ra77. (Corresponding author) PMCID in progress.
Soares KC, Rucki AA, Wu AA, Olino K, Xiao Q, Chai Y, Wamwea A, Bigelow E, Lutz E, Liu L, Yao S, Anders AA, Laheru D, Wolfgang CL, Edil BH, Schulick RD, Jaffee EM, Zheng L. PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T cell infiltration into pancreatic tumors. Journal of Immunotherapy 2015;38(1):1-11. (Corresponding author). PMCID: PMC4258151
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Recent News Articles and Media Coverage
Pancreatic Cancer and Immunotherapy Trials, Johns Hopkins Surgery (5/3/2017)