Skip Navigation
Find a Doctor
 
 
 
 

 

Photo of Dr. Keith Pratz

Keith William Pratz, MD

Assistant Professor of Oncology
Male
Appointment Phone

410-955-8964

Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

View All Locations
Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Assistant Professor of Oncology

Centers & Institutes

  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Hematologic Malignancies, Leukemia, Medical Oncology

Research Interests

My research interests include the development of therapies directed at activated signal transduction systems in cancer. In Acute Myeloid Leukemia (AML) one such activated pathway involves the receptor tyrosine kinase FLT3. FLT3 is mutated in about 1/3 of cases of adult AML and confers a poor prognosis. Several agents are in development targeting FLT3 and our laboratory has developed methods for the determination of the degree to which these compounds inhibit FLT3 over the course of the treatment cycle. We assay target in both circulating leukemia and use a plasma based assay for ex vivo target assessment in patients with insufficient circulating leukemia. We have found that transient inhibition of the target enzyme is associated with inferior clinical responses, and have used this knowledge to modify clinical trial design for improved target modulation. We are currently developing assays for compounds targeting the PI3 kinase pathway and the MEK/AKT pathway and plan on incorporating these correlatives into upcoming clinical trials.; Leukemia

Languages

  • English

Clinical Trial Keywords

  • Leukemia

Additional Resources

Additional Resources +
  • Education +

    Training

    • University of Medicine & Dentistry of New Jersey - (Camden NJ) (2002)

    Residencies

    • Mayo Clinic Medical School College of Medicine / Internal Medicine (Rochester MN) (2005)

    Fellowships

    • Johns Hopkins University School of Medicine / Oncology (Baltimore MD) (2009)

    Certifications

    • American Board of Internal Medicine / Medical Oncology (2009)
    • American Board of Internal Medicine / Internal Medicine (2005)
  • Research & Publications +
  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    401 N. Broadway
    Baltimore, MD 21231
    Phone: 410-502-7726
    Appointment Phone: 410-955-8964
    Fax: 410-614-1005
    Location Map

    Department/Division

    • Oncology

Is This You? Edit Profile

 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.